United States Patent
US Patent 8389708: Method of cancer treatment using siRNA silencing
US 8389708 · granted 2013-03-05
Abstract
The present invention is a method for the treatment of cancer involving tumor derived immunosuppression in a subject. The method comprises administering to a subject one or more siRNA constructs capable of inhibiting the expression of an immunosuppressive molecule. The invention also provides siRNA constructs and compositions.
| Patent Number | 8389708 |
|---|---|
| Title | Method of cancer treatment using siRNA silencing |
| Granted | 2013-03-05 |
| CPC Classification | C07H 21/04, C12N 15/11, C12Q 1/68 |
| Number of Claims | 5 |
Abstract
The present invention is a method for the treatment of cancer involving tumor derived immunosuppression in a subject. The method comprises administering to a subject one or more siRNA constructs capable of inhibiting the expression of an immunosuppressive molecule. The invention also provides siRNA constructs and compositions.
Claim 1
A composition comprising an siRNA construct directed to indoleamine 2,3-dioxygenase (IDO) mRNA, said siRNA binding to said IDO, wherein said binding preventsexpression of said IDO, thereby modulating IDO-directed tumoral immunosuppression in a mammalian subject and a pharmaceutically acceptable carrier, wherein said siRNA construct is within a liposome coupled to an anti-MAGE antibody that is targeted to atumor.
Claims
5 totalA composition comprising an siRNA construct directed to indoleamine 2,3-dioxygenase (IDO) mRNA, said siRNA binding to said IDO, wherein said binding preventsexpression of said IDO, thereby modulating IDO-directed tumoral immunosuppression in a mammalian subject and a pharmaceutically acceptable carrier, wherein said siRNA construct is within a liposome coupled to an anti-MAGE antibody that is targeted to atumor.