United States Patent
US Patent 7919525: Radiation protection by gamma-tocotrienol
US 7919525 ยท granted 2011-04-05
Abstract
The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using .gamma.-tocotrienol, .alpha.-tocopherol succinate or .gamma.-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of .gamma.-tocotrienol; or (2) oral administration of a therapeutically effective amount of .alpha.-tocopherol succinate or .gamma.-tocotrienol succinate or both.
| Patent Number | 7919525 |
|---|---|
| Title | Radiation protection by gamma-tocotrienol |
| Filed | 2004-02-17 |
| Granted | 2011-04-05 |
| Inventor(s) | Kumar; K. Sree, Srinivasan; Venkataraman, Seed; Thomas M., Papas; Andreas |
| Assignee | Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. |
| CPC Classification | A61K 31/355 |
| Number of Claims | 17 |
Abstract
The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using .gamma.-tocotrienol, .alpha.-tocopherol succinate or .gamma.-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of .gamma.-tocotrienol; or (2) oral administration of a therapeutically effective amount of .alpha.-tocopherol succinate or .gamma.-tocotrienol succinate or both.
Claim 1
A method for reducing lethality in a mammal caused by exposure to a lethal dose of ionizing radiation, said method comprising: prior to exposure to the lethal dose ofionizing radiation administering to said mammal a therapeutically effective amount of a pharmaceutical composition consisting essentially of .gamma.-tocotrienol in a pharmaceutically acceptable carrier, wherein the lethality to the mammal after exposureis reduced.
Claims
17 totalA method for reducing lethality in a mammal caused by exposure to a lethal dose of ionizing radiation, said method comprising: prior to exposure to the lethal dose ofionizing radiation administering to said mammal a therapeutically effective amount of a pharmaceutical composition consisting essentially of .gamma.-tocotrienol in a pharmaceutically acceptable carrier, wherein the lethality to the mammal after exposureis reduced.