United States Patent
US Patent 7528368: Electrospray ionization process and add-on device…
US 7528368 · granted 2009-05-05
Abstract
A process for ionizing a liquid can comprising flowing the liquid through a capillary wire bonding tip and applying sufficient voltage to electrospray the liquid sample as it exits therefrom. The electrospray ionization process can further involve passing a liquid sample through an axially disposed aperture in a ceramic capillary wire bonding tip in which the terminus of the aperture flares into a bell-shape where the liquid sample exits therefrom. An add-on device can include gel electroelution and separating devices, and a ceramic capillary sample injection tip for carrying out the aforesaid electrospray ionization process. An adjustably mounted cartridge can also be provided with the add-on device for interchangeably receiving the ceramic capillary sample injection tip.
| Patent Number | 7528368 |
|---|---|
| Title | Electrospray ionization process and add-on device with sample injection tip |
| Filed | 2006-12-20 |
| Granted | 2009-05-05 |
| Inventor(s) | Lenke; James H., Powell; Matthew |
| Assignee | Protea Biosciences, Inc. |
| CPC Classification | H01J 49/10 |
| Number of Claims | 69 |
Abstract
A process for ionizing a liquid can comprising flowing the liquid through a capillary wire bonding tip and applying sufficient voltage to electrospray the liquid sample as it exits therefrom. The electrospray ionization process can further involve passing a liquid sample through an axially disposed aperture in a ceramic capillary wire bonding tip in which the terminus of the aperture flares into a bell-shape where the liquid sample exits therefrom. An add-on device can include gel electroelution and separating devices, and a ceramic capillary sample injection tip for carrying out the aforesaid electrospray ionization process. An adjustably mounted cartridge can also be provided with the add-on device for interchangeably receiving the ceramic capillary sample injection tip.
Claim 1
An electrospray ionization process comprising flowing a liquid through a capillary wire bonding tip and applying sufficient voltage to electrospray said liquid sample asit is discharged from said capillary wire bonding tip.
Claims
69 totalAn electrospray ionization process comprising flowing a liquid through a capillary wire bonding tip and applying sufficient voltage to electrospray said liquid sample asit is discharged from said capillary wire bonding tip.