United States Patent
US Patent 7225080: Diagnosis method of inflammatory, fibrotic or…
US 7225080 · granted 2007-05-29
Abstract
The present invention is drawn to a new diagnosis method for detecting the extend of a inflammatory, fibrotic or cancerous disease in a patient, in particular liver fibrosis, in particular in a patient infected with hepatitis C virus, by using the serum concentration of easily detectable biological markers. The invention is also drawn to diagnosis kits for the implementation of the method.
| Patent Number | 7225080 |
|---|---|
| Title | Diagnosis method of inflammatory, fibrotic or cancerous disease using biochemical markers |
| Filed | 2003-08-27 |
| Granted | 2007-05-29 |
| Inventor(s) | Poynard; Thierry |
| Assignee | Assistance Publique-Hopitaux de Paris |
| CPC Classification | G06F 19/00, G01N 33/573 |
| Number of Claims | 71 |
Abstract
The present invention is drawn to a new diagnosis method for detecting the extend of a inflammatory, fibrotic or cancerous disease in a patient, in particular liver fibrosis, in particular in a patient infected with hepatitis C virus, by using the serum concentration of easily detectable biological markers. The invention is also drawn to diagnosis kits for the implementation of the method.
Claim 1
A method for diagnosis of an inflammatory, a fibrotic or a cancerous disease in a patient comprising the steps of: a) measuring the values of at least four biochemicalmarkers selected from the group consisting of .alpha.2-macroglobulin, AST (aspartate aminotransferase), ALT (alanine aminotransferase), GGT (gammaglutamyl transpeptidase), .gamma.-globulin, total bilirubin, albumin, .alpha.1-globulin, .alpha.2-globulin,haptoglobin, .beta.-globulin, apoA1, IL-10, TGF-.beta.1, apoA2, and apoB in the serum or plasma of said patient; b) combining said values through a logistic function including said markers; and c) analyzing the end value of said logistic function inorder to determine the presence of liver fibrosis and/or liver necroinflammatory lesions in said patient.
Claims
71 totalA method for diagnosis of an inflammatory, a fibrotic or a cancerous disease in a patient comprising the steps of: a) measuring the values of at least four biochemicalmarkers selected from the group consisting of .alpha.2-macroglobulin, AST (aspartate aminotransferase), ALT (alanine aminotransferase), GGT (gammaglutamyl transpeptidase), .gamma.-globulin, total bilirubin, albumin, .alpha.1-globulin, .alpha.2-globulin,haptoglobin, .beta.-globulin, apoA1, IL-10, TGF-.beta.1, apoA2, and apoB in the serum or plasma of said patient; b) combining said values through a logistic function including said markers; and c) analyzing the end value of said logistic function inorder to determine the presence of liver fibrosis and/or liver necroinflammatory lesions in said patient.