United States Patent
US Patent 6946120: Pharmaceutical composition
US 6946120 ยท granted 2005-09-20
Abstract
A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.
| Patent Number | 6946120 |
|---|---|
| Title | Pharmaceutical composition |
| Filed | 2002-04-16 |
| Granted | 2005-09-20 |
| Inventor(s) | Deo; Peter Paul, Tait; Russell John, Chiu So; Tony |
| Assignee | Connetics Australia Pty. Ltd. |
| Number of Claims | 22 |
Abstract
A pharmaceutical composition for topical administration, including, as the pharmaceutically active component, at least 5% by weight, based on the total weight of the composition of a piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; an acid in an amount to completely solubilise the piperidinopyrimidine derivative or a pharmaceutically acceptable salt thereof; a solvent composition including at least two of water, a lower alcohol and a co-solvent selected from one or more of the group consisting of aromatic and polyhydric alcohols; wherein when the co-solvent includes propylene glycol, it is present in an amount of less than approximately 10% by weight.
Claim 1
A homogeneous aerosol formulation, said homogeneous aerosol formulation consisting essentially of: approximately 5% or greater by weight of minoxidil or a pharmaceuticallyacceptable salt thereof; an acid in an amount effective to solubilize the minoxidil or a pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid,and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof; a solvent of water and a lower alcohol wherein the ratio of water toalcohol is in a range of approximately 9:1 to 1:9 by volume; and a co-solvent of a polyhydric alcohol selected from 1,3-butylene glycol, polyethylene glycol, hexylene glycol, dipropylene glycol, glycerol or propylene glycol at less than approximately10% by weight; wherein the final product of the homogeneous aerosol formulation is foam or a mousse.
Claims
22 totalA homogeneous aerosol formulation, said homogeneous aerosol formulation consisting essentially of: approximately 5% or greater by weight of minoxidil or a pharmaceuticallyacceptable salt thereof; an acid in an amount effective to solubilize the minoxidil or a pharmaceutically acceptable salt thereof, wherein the acid is a mineral acid selected from the group consisting of hydrochloric acid, sulphuric acid, nitric acid,and phosphoric acid, or an organic acid selected from the group consisting of citric acid, acetic acid, succinic acid, maleic acid, benzoic acid, lactic acid and mixtures thereof; a solvent of water and a lower alcohol wherein the ratio of water toalcohol is in a range of approximately 9:1 to 1:9 by volume; and a co-solvent of a polyhydric alcohol selected from 1,3-butylene glycol, polyethylene glycol, hexylene glycol, dipropylene glycol, glycerol or propylene glycol at less than approximately10% by weight; wherein the final product of the homogeneous aerosol formulation is foam or a mousse.