United States Patent
US Patent 6740338: Reduced form of Cenzyme Q in high bioavailability…
US 6740338 · granted 2004-05-25
Abstract
The present invention relates to a reduced form of Coenzyme Q also known as ubiquinol in oral dosage form such as a gelatin capsule, preferably a soft gelatin capsule. Compositions according to the present invention include storage stable compositions comprising effective amounts of ubiquinol in combination with an amount of a reducing agent effective to maintain ubiquinol in its reduced state when formulated in capsules, tablets and other orally administrable form. Methods of use are also disclosed.
| Patent Number | 6740338 |
|---|---|
| Title | Reduced form of Cenzyme Q in high bioavailability stable oral dosage form |
| Filed | 2000-01-20 |
| Granted | 2004-05-25 |
| Inventor(s) | Chopra; Raj K. |
| Number of Claims | 44 |
Abstract
The present invention relates to a reduced form of Coenzyme Q also known as ubiquinol in oral dosage form such as a gelatin capsule, preferably a soft gelatin capsule. Compositions according to the present invention include storage stable compositions comprising effective amounts of ubiquinol in combination with an amount of a reducing agent effective to maintain ubiquinol in its reduced state when formulated in capsules, tablets and other orally administrable form. Methods of use are also disclosed.
Claim 1
A composition comprising ubiquinone and an amount of ascorbyl palmitate as a reducing agent effective to reduce said ubiquinone to ubiquinol, said composition furthercomprising an amount of a pharmaceutically acceptable surfactant, triglyceride, vegetable oil or mixtures thereof optionally in combination with a solvent, effective to solubilize said ubiquinone, ubiquinol and said reducing agent, wherein saidubiquinol, after reduction of said ubiquinone, comprises more than 95% by weight of a total amount of ubiquinol and ubiquinone in said composition.
Claims
44 totalA composition comprising ubiquinone and an amount of ascorbyl palmitate as a reducing agent effective to reduce said ubiquinone to ubiquinol, said composition furthercomprising an amount of a pharmaceutically acceptable surfactant, triglyceride, vegetable oil or mixtures thereof optionally in combination with a solvent, effective to solubilize said ubiquinone, ubiquinol and said reducing agent, wherein saidubiquinol, after reduction of said ubiquinone, comprises more than 95% by weight of a total amount of ubiquinol and ubiquinone in said composition.