United States Patent
US Patent 6627660: Stabilized thyroxine compounds
US 6627660 ยท granted 2003-09-30
| Patent Number | 6627660 |
|---|---|
| Title | Stabilized thyroxine compounds |
| Filed | 1999-11-16 |
| Granted | 2003-09-30 |
| Inventor(s) | Thomas Piccariello, Anne F. LeClercq |
| Assignee | New River Pharmaceuticals Inc |
| CPC Classification | A61K31/19, A61K31/197, A61K31/195 |
| Number of Claims | 24 |
Abstract
Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing through the proposed pathway. The prodrug will be hydrolyzed in the stomach or the gut into thyroxine and the biologically inert dimethylphosphinic acid. Related products may be stabilized with the same or similar protecting groups.
Claims Summary
1. A composition comprising thyroxine protected at a phenolic hydroxyl with a protecting group, wherein said protecting group is a dialkylphosphinate.