United States Patent
US Patent 6562350: Combined vaccine against both HAV and measles…
US 6562350 · granted 2003-05-13
| Patent Number | 6562350 |
|---|---|
| Title | Combined vaccine against both HAV and measles virus and method of producing it |
| Filed | 1999-10-13 |
| Granted | 2003-05-13 |
| Inventor(s) | Pengfu Wang, Jingye Lu, Guangpu Li, Baosheng Xie, Zongming Song, Shuyan Li |
| Assignee | Changchun Institute of Biological Products |
| CPC Classification | A61K39/12, A61K39/00, C12N7/00 |
| Number of Claims | 1 |
Abstract
A combined hepatitis A-measles live vaccine, its lyophilized formulations with enhanced storage stability and methods of preparing the same by mixing the viral stocks of hepatitis A virus and measles virus or by propagating the two viruses on same diploid cell substrate are disclosed. The combined live vaccine thus prepared is a useful vaccine for preventing the infections with hepatitis A and measles without causing any interference between antigenicity of the two viruses and any serious adverse events due to their mixing or co-culturing.
Claims Summary
1. A combined hepatitis A-measles vaccine, comprising a combination of prophylactically effective titers of attenuated hepatitis A live virus and prophylactically effective titers of attenuated measles live virus, wherein said combination does not induce any mutual interference on immune response and immunogenicity.
Inventors
Assignee
Changchun Institute of Biological Products