United States Patent
US Patent 5840331: Use of .gamma.-hydroxybutyrate for the…
US 5840331 · granted 1998-11-24
Abstract
Methods for reestablishing normal nocturnal growth hormone and prolactin secretion in adults with low slow-wave (deep) sleep are provided. In particular, methods are disclosed where .gamma.-hydroxybutyrate is orally administered to subjects just prior to retiring.
| Patent Number | 5840331 |
|---|---|
| Title | Use of .gamma.-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin |
| Filed | 1995-06-07 |
| Granted | 1998-11-24 |
| Inventor(s) | Scharf; Martin B., Van Cauter; Eve |
| Assignee | Arch Development Corporation |
| Number of Claims | 24 |
Abstract
Methods for reestablishing normal nocturnal growth hormone and prolactin secretion in adults with low slow-wave (deep) sleep are provided. In particular, methods are disclosed where .gamma.-hydroxybutyrate is orally administered to subjects just prior to retiring.
Claim 1
A method for stimulating the release of growth hormone or prolactin in a human subject comprising the steps of: (a) identifying a human subject having age-related suppression of growth hormone or prolactin release; and then (b) orally administering to said human subject, within one hour prior to retiring, a unit dose of .gamma.-hydroxybutyrate of about 2 to 5 g, said unit dose effective to increase the release of growth hormone or prolactin.
Claims
24 totalA method for stimulating the release of growth hormone or prolactin in a human subject comprising the steps of: (a) identifying a human subject having age-related suppression of growth hormone or prolactin release; and then (b) orally administering to said human subject, within one hour prior to retiring, a unit dose of .gamma.-hydroxybutyrate of about 2 to 5 g, said unit dose effective to increase the release of growth hormone or prolactin.