United States Patent
US Patent 5990285: Catalytic antibodies against cocaine
US 5990285 ยท granted 1999-11-23
| Patent Number | 5990285 |
|---|---|
| Title | Catalytic antibodies against cocaine |
| Filed | 1995-06-07 |
| Granted | 1999-11-23 |
| Inventor(s) | Donald W. Landry, Kang Zhao |
| Assignee | Columbia University in the City of New York |
| CPC Classification | C07F9/00, A61P39/00, C07D451/00 |
| Number of Claims | 5 |
Abstract
This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmaceutical composition for decreasing concentration in a subject using the antibodies produced.
Claims Summary
1. An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and against the compound having the structure: ##STR60## wherein R’ is O or CH2 and R is a hydrocarbon chain or a series of hydrocarbon linked by amide, ester or other functional group, capable of linking to a carrier protein.
Inventors
Assignee
Columbia University in the City of New York