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United States Patent

US Patent 5439930: Biologically active n-acylprolydipeptides having…

US 5439930  ·  granted 1995-08-08

Patent Number 5439930
Title Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects
Filed 1992-10-14
Granted 1995-08-08
Inventor(s) Sergei B. Seredenin, Tatiana A. Voronina, Tatiana A. Gudasheva, Rita U. Ostrovskaya, Grigori G. Rozantsev, Alexander P. Skoldinov, Sergei S. Trophimov, James A. Halikas, Taisija L. Garibova
Assignee Russian-American Institute for New Drug Development
CPC Classification C07K5/06165, C07K5/06, C07K5/04
Number of Claims 9

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Abstract

A novel class of substances of N-acyl-prolyldipeptides, which possess psychotropic activity and particularly facilitate learning and memory are described. The N-acyl-prolyldipeptides of the invention have the formula: (1) wherein R1=(C4-C5) alkyl, cycloalkyl, aralkyl, or aryl; R2=H1 (C1-C4) alkyl, carbamidoalkyl, or carbalkoxyalkyl; R3=NH2, NH(alkyl), N(alkyl)2, OH, or alkoxy; and n=0-3, preferably 0-2.

Claims Summary

1. A compound of the formula: ##STR10## wherein: (a) R1 is CH2 C6 H5 ;(b) R2 is selected from the group consisting of H, CH3, CH(CH3)2, CH2 CH(CH3)2, CH2 C(O)OC2 H5, (CH2)2 C(O)OC2 H5, and CH2 C(O)NH2 ;

Inventors

Assignee

Russian-American Institute for New Drug Development

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