| Patent Number |
Title Of Patent |
Date Issued |
| 7442501 |
SQV nucleic acids and polypeptides |
October 28, 2008 |
| The invention generally features sqv nucleic acid and polypeptide molecules associated with connective tissue diseases, progeroid disorders, and aging, and methods for isolating such molecules. |
| 7217411 |
CeSERT genes, proteins, and modulatory compounds |
May 15, 2007 |
| The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological activity of a SERT |
| 7138510 |
Cloning sequencing and characterization of two cell death genes and uses therefor |
November 21, 2006 |
| Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally |
| 7071302 |
Cloning sequencing and characterization of two cell death genes and uses therefor |
July 4, 2006 |
| Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally |
| 7026466 |
Serotonin-gated anion channel |
April 11, 2006 |
| Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions. |
| 6977175 |
Nucleic acids encoding lin-37 and uses thereof |
December 20, 2005 |
| The invention provides novel genes involved in cell fate and cell proliferation, including lin-37, lin-35, lin-53, lin-55, lin-52, and lin-54 in multiple species and an E2F-1 gene of C. elegans. Methods for utilizing the genes and encoded proteins are also provided. |
| 6939850 |
Altered human interleukin-1.beta. convertase (ICE), NEDD-2, and C. elegans ced-3 polypeptides an |
September 6, 2005 |
| Described herein is the discovery that human interleukin-1.beta. convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 |
| 6902732 |
Identification and characterization of a gene which protects cells from programmed cell death an |
June 7, 2005 |
| The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi |
| 6841145 |
CeSERT genes, proteins, and modulatory compounds |
January 11, 2005 |
| The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin retake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological activity of a SERT and |
| 6812376 |
Serotonin-gated anion channel |
November 2, 2004 |
| Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions. |
| 6723893 |
Mice having a mutant SOD-1-encoding transgene |
April 20, 2004 |
| Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed. |
| 6596495 |
EGL-1, a new protein required for programmed cell death in C. elegans that interacts with the BC |
July 22, 2003 |
| The invention provides a novel protein, EGL-1, involved in cell death and methods for identifying compounds and genes which affect the cell death pathway. |
| 6465617 |
Identification and characterization of a gene which protects cells from programmed cell death an |
October 15, 2002 |
| The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi |
| 6312947 |
Identification and characterization of a gene which protects cells from programmed cell death an |
November 6, 2001 |
| The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi |
| 6069296 |
Regulators of G-protein signalling |
May 30, 2000 |
| Disclosed is substantially pure DNA encoding a C. elegans Egl-10 polypeptide; substantially pure Egl-10 polypeptide; methods of obtaining RGS encoding DNA and RGS polypeptides; and methods of using the RGS DNA and RGS polypeptides to regulate G-protein signalling. |
| 5962301 |
Relatedness of human interleukin-1.beta. convertase gene to a C. elegans cell death gene, inhibi |
October 5, 1999 |
| Described herein is the discovery that human interleukin-1.beta. convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3 |
| 5929207 |
Regulators of G-protein signalling |
July 27, 1999 |
| Disclosed is substantially pure DNA encoding a C. elegans EGL-10 polypeptide; substantially pure EGL-10 polypeptide; methods of obtaining rgs encoding DNA and RGS polypeptides; and methods of using the rgs DNA and RGS polypeptides to regulate G-protein signalling. |
| 5849290 |
Compounds and methods for the diagnosis, treatment and prevention of diseases of cell death |
December 15, 1998 |
| Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed. |
| 5843641 |
Methods for the daignosis, of familial amyotrophic lateral sclerosis |
December 1, 1998 |
| Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed. |
