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H. Robert Horvitz Patents
Inventor:
Horvitz; H. Robert
Address:
Auburndale, MA
No. of patents:
21
Patents:












Patent Number Title Of Patent Date Issued
7670778 Tumor suppressor pathway in C. elegans March 2, 2010
The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their encoded polypeptides,
7635563 High throughput methods relating to microRNA expression analysis December 22, 2009
The invention relates to methods and compositions for microRNA expression analysis using microarrays.
7442501 SQV nucleic acids and polypeptides October 28, 2008
The invention generally features sqv nucleic acid and polypeptide molecules associated with connective tissue diseases, progeroid disorders, and aging, and methods for isolating such molecules.
7217411 CeSERT genes, proteins, and modulatory compounds May 15, 2007
The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological activity of a SERT
7138510 Cloning sequencing and characterization of two cell death genes and uses therefor November 21, 2006
Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally
7071302 Cloning sequencing and characterization of two cell death genes and uses therefor July 4, 2006
Described herein are genes shown to be essential for programmed cell death in C. elegans, their encoded products (RNA and polypeptides), antibodies directed against the encoded polypeptides; probes for identifying structurally related genes and bioassays for identifying functionally
7026466 Serotonin-gated anion channel April 11, 2006
Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions.
6977175 Nucleic acids encoding lin-37 and uses thereof December 20, 2005
The invention provides novel genes involved in cell fate and cell proliferation, including lin-37, lin-35, lin-53, lin-55, lin-52, and lin-54 in multiple species and an E2F-1 gene of C. elegans. Methods for utilizing the genes and encoded proteins are also provided.
6939850 Altered human interleukin-1.beta. convertase (ICE), NEDD-2, and C. elegans ced-3 polypeptides an September 6, 2005
Described herein is the discovery that human interleukin-1.beta. convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3
6902732 Identification and characterization of a gene which protects cells from programmed cell death an June 7, 2005
The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi
6841145 CeSERT genes, proteins, and modulatory compounds January 11, 2005
The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin retake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological activity of a SERT and
6812376 Serotonin-gated anion channel November 2, 2004
Disclosed is a novel serotonin-gated anion channel that is permeable to chloride ions. Also disclosed are methods for the screening of therapeutics useful for treating serotonin-mediated cellular responses and conditions, as well as diagnostic methods for identifying such conditions.
6723893 Mice having a mutant SOD-1-encoding transgene April 20, 2004
Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed.
6596495 EGL-1, a new protein required for programmed cell death in C. elegans that interacts with the BC July 22, 2003
The invention provides a novel protein, EGL-1, involved in cell death and methods for identifying compounds and genes which affect the cell death pathway.
6465617 Identification and characterization of a gene which protects cells from programmed cell death an October 15, 2002
The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi
6312947 Identification and characterization of a gene which protects cells from programmed cell death an November 6, 2001
The present invention relates to genes, referred to herein as cell death-protective genes, which protect cells against programmed cell death by antagonizing the activities of genes which cause cell death. As described herein, a cell death-protective gene from the nematode Caenorhabdi
6069296 Regulators of G-protein signalling May 30, 2000
Disclosed is substantially pure DNA encoding a C. elegans Egl-10 polypeptide; substantially pure Egl-10 polypeptide; methods of obtaining RGS encoding DNA and RGS polypeptides; and methods of using the RGS DNA and RGS polypeptides to regulate G-protein signalling.
5962301 Relatedness of human interleukin-1.beta. convertase gene to a C. elegans cell death gene, inhibi October 5, 1999
Described herein is the discovery that human interleukin-1.beta. convertase (ICE) is structurally similar to the protein encoded by the C. elegans cell death gene, ced-3. Comparative and mutational analyses of the two proteins, together with previous observations, suggest that the Ced-3
5929207 Regulators of G-protein signalling July 27, 1999
Disclosed is substantially pure DNA encoding a C. elegans EGL-10 polypeptide; substantially pure EGL-10 polypeptide; methods of obtaining rgs encoding DNA and RGS polypeptides; and methods of using the rgs DNA and RGS polypeptides to regulate G-protein signalling.
5849290 Compounds and methods for the diagnosis, treatment and prevention of diseases of cell death December 15, 1998
Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed.
5843641 Methods for the daignosis, of familial amyotrophic lateral sclerosis December 1, 1998
Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed.










 
 
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