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Robert H. Grubbs Patents
Inventor:
Grubbs; Robert H.
Address:
South Pasadena, CA
No. of patents:
108
Patents:


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Patent Number Title Of Patent Date Issued
RE38676 Thermally initiated polymerization of olefins using ruthenium or osmium vinylidene complexes December 21, 2004
The present invention generally relates to the use of certain ruthenium and osmium complexes that are substantially inactive at a first temperature (preferably about room temperature) but becomes progressively more active at a higher second temperature. This difference in reactivities al
RE37194 High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useab May 29, 2001
A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of re
8299276 Interlocked molecules and related components, compositions, methods and systems October 30, 2012
[c2] daisy chain macromers, dimers and polymers and related compositions, materials, methods and systems are described.
8298521 Treatment for eye disorder October 30, 2012
The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's m
8236344 Engineered proteins, and methods of making and using August 7, 2012
The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
8039566 Olefin metathesis initiators bearing thiazol-2-ylidene ligands October 18, 2011
This invention relates to olefin metathesis catalysts general formula (I): ##STR00001## having a thiazol-2-ylidene ligand of general formula (II): ##STR00002## The catalysts have been found to be particularly good initiators of (a) ring-closing metathesis reactions used to prepare
8008224 Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted August 30, 2011
The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen atom contained within the 5-membered heterocyclic ring, wherein the nitrogen atom is direc
7837326 Lenses capable of post-fabrication power modification November 23, 2010
The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. Wh
7798644 Lenses capable of post-fabrication power modification September 21, 2010
The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. Wh
7750172 High metathesis activity ruthenium and osmium carbene complexes July 6, 2010
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The car
7727544 Treatment of myopia June 1, 2010
The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment and/or prevention of myopia. An activating energy source is utilized to photopolymerize or cross
7683180 Group 8 transition metal carbene complexes as enantionselective olefin metathesis catalysts March 23, 2010
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions, and for enantioselective reactions in particular. The synthesis of these complexes and details of their use as catalysts is also provided.
7598330 Cross-metathesis of olefins directly substituted with an electron-withdrawing group using transi October 6, 2009
The invention pertains to the use of Group 8 transition metal alkylidene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand and at least one electron donor ligand in
7560499 Initiator and ultraviolet absorber blends for changing lens power by ultraviolet light July 14, 2009
Novel blends of photo-initiators and photo-absorbers are disclosed. By the proper selection of the type and amount of absorber and initiator used in a composition, it is possible to regulate the conditions under which photo-induced reactions occur. In a specific embodiment, blends of UV
7550310 Techniques and systems for analyte detection June 23, 2009
Techniques are used to detect and identify analytes. Techniques are used to fabricate and manufacture sensors to detect analytes. An analyte (810) is sensed by sensors (820) that output electrical signals in response to the analyte. The electrical signals may be preprocessed (830) by
7507854 Impurity reduction in Olefin metathesis reactions March 24, 2009
The present invention relates to the use of isomerization inhibitors in olefin metathesis reactions. The inhibitors are low molecular weight organic acids such as formic acid, acetic acid, benzoic acid, and the like.
7381404 Treatment for dry macular degeneration June 3, 2008
The present invention relates to altering the physical and/or chemical properties of at least part of at least one tissue in the eye. In a specific embodiment, it relates to the treatment of any eye disorder, although in particular embodiments the individual has a thickened Bruch's m
7329758 Imidazolidine-based metal carbene metathesis catalysts February 12, 2008
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are of the formula ##STR00001## wherein: M is ruthenium or osmium; X and X.sup.1 are each independently an anionic l
7288666 High metathesis activity ruthenium and osmium metal carbene complexes October 30, 2007
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The car
7262315 Transition metal oxo, sulfido and amido complexes as catalysts of nucleophilic addition reaction August 28, 2007
Methods are provided for carrying out nucleophilic addition reactions using oxo, sulfido or amido complexes of transition metals as reaction catalysts. Exemplary catalysts are oxo complexes of Group 7 transition metals, with rhenium (V) oxo complexes, including dioxo complexes, prefe
7241009 Crosslinking of silicones presence of functionalized silicones July 10, 2007
Methods and materials are disclosed for the production of optical elements, in particular intraocular lenses (IOL) that incorporate any amount (0 to 99%) of refraction and/or shape modulating compound into a substantially crosslinked first polymeric matrix. The materials produced acc
7237893 Light adjustable lenses capable of post-fabrication power modification via multi-photon processe July 3, 2007
The invention relates to novel photoinitiators and their use in light adjustable compositions. The initiatives comprise two or more multiphoton chromophores linked by a bridging compound. The bridging compound consists of a material that is compatible with the base material of the li
7229634 Engineered proteins, and methods of making and using June 12, 2007
The present invention provides engineered proteins and biomedical products made from the engineered proteins. The biomedical products include lenses useful for ophthalmic purposes.
7210783 Lenses capable of post-fabrication power modification May 1, 2007
The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. Wh
7175885 Compositionally different polymer-based sensor elements and methods for preparing same February 13, 2007
The present invention provides a combinatorial approach for preparing arrays of chemically sensitive polymer-based sensors which are capable of detecting the presence of a chemical analyte in a fluid in contact therewith. The described methods and devices comprise combining varying r
7134755 Customized lenses November 14, 2006
The invention relates to a method of customizing lenses using an external stimulus such as light. Fine-tuning of the lens to match the precise optical requirements using the same lens is also possible. The lenses are self-contained and do not require the addition or removal of significan
7102047 High metathesis activity ruthenium and osmium metal carbene complexes September 5, 2006
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The car
7074840 Light adjustable lenses capable of post-fabrication power modification via multi-photon processe July 11, 2006
The invention relates to novel photoinitiators and their use in light adjustable compositions. The initiatives comprise two or more multiphoton chromophores linked by a bridging compound. The bridging compound consists of a material that is compatible with the base material of the li
7061061 Techniques and systems for analyte detection June 13, 2006
Techniques are used to detect and identify analytes. Techniques are used to fabricate and manufacture sensors to detect analytes. An analyte (810) is sensed by sensors (820) that output electrical signals in response to the analyte. The electrical signals may be preprocessed (830) by
7034096 Ring-expansion of cyclic olefins metathesis reactions with an acyclic diene April 25, 2006
This invention relates generally to synthetic procedures that include the step of ring-opening metathesis of cyclic olefins and reaction with an acyclic diene co-reactant to produce olefin macrocycles by ring expansion, or alternatively. The ring expansion of the cyclic olefin is pro
7022789 Telechelic alkadiene polymers with crosslinkable end groups and methods for making the same April 4, 2006
The present invention relates to telechelic polymers having crosslinkable end groups of the formula ##STR00001## and methods for preparing the same wherein n is an integer; ##STR00002## is an alkadienyl group; Y is an alkyl group; and Z is crosslinkable end group. In general, the
6987154 Synthesis of A,B-alternating copolymers by olefin metathesis reactions of cyclic olefins or olef January 17, 2006
This invention relates generally to synthetic procedures that include the step of ring-opening metathesis of cyclic olefins and reaction with an acyclic diene co-reactant to produce regularly repeating A,B-alternating olefin polymers. The A,B-alternating polymers are produced by varying
6890715 Sensors of conducting and insulating composites May 10, 2005
The present invention provides a class of sensors prepared from at least a first material having a positive temperature coefficient of resistance and a second non-conductive or insulating material compositionally different than the first material that show an increase sensitivity detecti
6884859 Ring-opening metathesis polymerization of bridged bicyclic and polycyclic olefins containing two April 26, 2005
A method is provided for synthesizing a polymer in a controlled fashion using a ring-opening metathesis polymerization (ROMP) reaction, wherein polymerization is carried out using a catalytically effective amount of an olefin metathesis catalyst and a bridged bicyclic or polycyclic olefi
6867274 Telechelic alkadiene polymers with crosslinkable end groups and methods for making the same March 15, 2005
The present invention relates to telechelic polymers having crosslinkable end groups of the formula ##STR1##and methods for preparing the same wherein n is an integer; ##STR2##is an alkadienyl group; Y is an alkyl group; and Z is crosslinkable end group. In general, the inventive syn
6838489 High activity metal carbene metathesis catalysts generated using a thermally activated N-heteroc January 4, 2005
The invention provides a method for converting a less active or slower to initiate system to a higher activity system so that at the end of a polymerization the most active species is present in the system. The invention generally relates to a process for converting a less active or
6824266 Lenses capable of post-fabrication power modification November 30, 2004
The present invention relates to lenses that are capable of post-fabrication power modifications. In general, the inventive lenses comprise (i) a first polymer matrix and (ii) a refraction modulating composition that is capable of stimulus-induced polymerization dispersed therein. Wh
6818586 Hexacoordinated ruthenium or osmium metal carbene metathesis catalysts November 16, 2004
The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula ##STR1##wherein: M is ruthenium or osmium; X and X.sup.1 are the same or different and are each independently an
6813097 Lenses capable of post-fabrication modulus change November 2, 2004
Novel optical elements are provided which are capable of post fabrication modifications. Specifically, the invention includes lenses, such as intraocular lens, which can undergo changes in storage modulus after fabrication.
6806325 High metathesis activity ruthenium and osmium metal carbene complexes October 19, 2004
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene
6803429 Selective ring-opening cross-metathesis of cycloolefins October 12, 2004
A catalytic method is provided for a ring-opening cross-metathesis reaction between a cycloolefinic substrate and a second olefinic reactant, wherein the catalyst used is a transition metal alkylidene complex substituted with an N-heterocyclic carbene ligand. The substrates are selected
6794534 Synthesis of functionalized and unfunctionalized olefins via cross and ring-closing metathesis September 21, 2004
The invention is directed to the cross-metathesis and ring-closing metathesis reactions between geminal disubstituted olefins and terminal olefins, wherein the reaction employs a Ruthenium or Osmium metal carbene complex. Specifically, the invention relates to the synthesis of .alpha
6759537 Hexacoordinated ruthenium or osmium metal carbene metathesis catalysts July 6, 2004
The present invention relates to novel hexacoordinated metathesis catalysts and to methods for making and using the same. The inventive catalysts are of the formula ##STR1##wherein: M is ruthenium or osmium; X and X.sup.1 are the same or different and are each independently an
6752964 Polymer/plasticizer based sensors June 22, 2004
This invention relates to a novel class of vapor sensors with tunable properties. More particularly, this invention relates to vapor sensors modified by the addition of a compatible small molecule of low volatility, i.e., a plasticizer. In certain aspects, the invention relates to a sens
6749632 Application of wavefront sensor to lenses capable of post-fabrication power modification June 15, 2004
The present invention relates to methods of implementing an optical element having a refraction modulating composition. The methods include using a wavefront sensor to provide an optical measurement of the optical element. The present invention also relates to systems comprising an optic
6696597 Metathesis syntheses of pheromones or their components February 24, 2004
The present invention relates to metathesis syntheses for insect sex-attractant pheromones or their components, such as E-5-decenyl acetate, the major component of the Peach Twig Borer pheromone; (5R,6S)-6-acetoxy-5-hexadecanolide, the mosquito oviposition attractant pheromone; E9,Z1
6696536 ABA triblock and diblock copolymers and methods of preparing the same February 24, 2004
The invention discloses a method for preparing a triblock copolymer of the formula: ##STR1##comprising: (a) contacting a cycloalkene with a chain transfer agent of the formula:wherein n and m are integers; Z is an ATRP initiator and --Y.dbd.Y-- is an alkenyl group; and, R' is selected
6624265 Ruthenium metal alkylidene complexes coordinated with triazolylidene ligands that exhibit high o September 23, 2003
The invention discloses ruthenium alkylidene complexes of the type (PCy.sub.3)(L)Cl.sub.2 Ru(CHPh), where L is a triazolylidene ligand of the general formula: ##STR1##These catalysts have been found to be considerably more active for olefin metathesis at elevated temperatures than th
6613910 One-pot synthesis of group 8 transition metal carbene complexes useful as olefin metathesis cata September 2, 2003
The invention provides a novel method for synthesizing transition metal carbene complexes useful as olefin metathesis catalysts. The method is a convenient one-pot synthesis in which transition metal carbenes are prepared in high yield from readily available starting materials via a
6610626 Highly active metathesis catalysts generated in situ from inexpensive and air stable precursors August 26, 2003
The invention provides a process for the in-situ generation of a metathesis active catalyst of the formula: ##STR1##comprising contacting an NHC carbene with a dimer of the formula [(arene)MX.sup.1 X].sub.2 and an ##STR2##alkyne of the formula RC.ident.CR.sup.1 or wherein M is rut
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