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Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate |
| T102907 |
Process to 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate
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| Inventor: |
Halfon, et al. |
| Date Issued: |
April 5, 1983 |
| Application: |
06/381,997 |
| Filed: |
May 25, 1982 |
| Inventors: |
Halfon; Marc (Plainsboro, NJ)
Scharpf; William G. (Yardley, PA)
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| U.S. Class: |
560/124 |
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| Abstract: |
3-Phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate is prepared in greater than 90% yield by alcoholysis of lower alkyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylates with 3-phenoxybenzyl alcohol. A lower alkyl alcohol, e.g., methanol or ethanol, is generated as a by-product.The process is conducted under reflux at a temperature of at least 100.degree. C. in an inert solvent between approximately stoichiometric amounts of the reactants. The solvent is selected to form an azeotropic mixture with, or boil at a higher temperature than, the lower alkyl alcohol by-product, and the by-product is removed from the mixture by distillation as it is produced. If lower alkyl is methyl or ethyl, n-octane, benzene, toluene, xylene, or mesitylene may be employed, for example.The process is promoted by lower alkyl titanium alkoxide catalysts. The purity of the product 3-phenoxybenzyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate, which is obtained as a bottoms residue after stripping the solvent, is high enough, greater than 90%, to be suitable for use in commerce as the pyrethroid insecticide "permethrin" without further purification. The purity is enhanced by the use of only 0.001-0.01 mole of the catalyst per mole of lower alkyl 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. To avoid hydrolysis of the catalyst, the reaction is carried out under substantially anhydrous conditions. |
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