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5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones |
| T102303 |
5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones
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| Patent Drawings: | |
| Inventor: |
Morrow |
| Date Issued: |
October 5, 1982 |
| Application: |
06/271,296 |
| Filed: |
June 8, 1981 |
| Inventors: |
Morrow; Duane F. (Evansville, IN)
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| U.S. Class: |
544/362 |
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| Abstract: |
5,6,7,8-Tetrahydrotriazolo{4,3-a}pyridin-3(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the 2- position of the tetrahydrotriazolo{4,3-a}pyridinone component via an alkylene chain of 3 or 4 carbon atoms are disclosed. Examples are compounds having the formula ##STR1## wherein R is lower alkyl or alkoxy (each having 1 to 4 carbon atoms inclusive), cyano, halogen, or trifluoromethyl; and Y is an alkylene chain of 3 or 4 carbon atoms. The compound in which R is 3-Cl and Y is trimethylene exhibits central nervous system pharmacological properties in standard laboratory tests which are predictive of useful anti-psychotic, antidepressant, and antianxiety action. |
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