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5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones
T102303 5,6,7,8-Tetrahydrotriazolo{4,3-alpha}-pyridin-3(2H)-ones
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Inventor: Morrow
Date Issued: October 5, 1982
Application: 06/271,296
Filed: June 8, 1981
Inventors: Morrow; Duane F. (Evansville, IN)
Assignee:
Primary Examiner:
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U.S. Class: 544/362
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Abstract: 5,6,7,8-Tetrahydrotriazolo{4,3-a}pyridin-3(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the 2- position of the tetrahydrotriazolo{4,3-a}pyridinone component via an alkylene chain of 3 or 4 carbon atoms are disclosed. Examples are compounds having the formula ##STR1## wherein R is lower alkyl or alkoxy (each having 1 to 4 carbon atoms inclusive), cyano, halogen, or trifluoromethyl; and Y is an alkylene chain of 3 or 4 carbon atoms. The compound in which R is 3-Cl and Y is trimethylene exhibits central nervous system pharmacological properties in standard laboratory tests which are predictive of useful anti-psychotic, antidepressant, and antianxiety action.
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