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Triazolo[4,3-a]pyridin-3(2H)-ones |
| T100505 |
Triazolo[4,3-a]pyridin-3(2H)-ones
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| Inventor: |
Morrow, et al. |
| Date Issued: |
April 7, 1981 |
| Application: |
06/130,900 |
| Filed: |
March 17, 1980 |
| Inventors: |
Morrow; Duane F. (Evansville, IN)
Wu; Yao H. (Evansville, IN)
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| U.S. Class: |
544/366 |
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| Abstract: |
Triazolo[4,3-a]pyridin-3-(2H)-one derivatives containing a 4-(optionally substituted phenyl)piperazinyl component attached to the two position of the triazolo-[4,3-a]pyridine component via a divalent radical such as --(CH.sub.2).sub.5 --, --(CH.sub.2).sub.6 --, --CH.sub.3 CH(CH.sub.3)CH.sub.2 --, --CH.sub.2 C(CH.sub.3).sub.2 CH.sub.2 --, --CH.sub.2 CH.dbd.CHCH.sub.2 --, --CH.sub.2 C.tbd.CCH.sub.2 --, --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- or a divalent cycloalkylene radical of 3 to 6 carbon atoms are disclosed. The compounds are useful in that they exhibit central nervous system pharmacological properties in standard laboratory tests considered predictive of analgetics, anti-psychotic (neuroleptics), antidepressant and antianxiety utility. Examples of specific embodiments of the invention are compounds having the formula |
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