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Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
RE44638 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
Patent Drawings:

Inventor: Fowler, et al.
Date Issued: December 10, 2013
Application:
Filed:
Inventors:
Assignee:
Primary Examiner: Willis; Douglas M
Assistant Examiner:
Attorney Or Agent: Morrison & Foerster LLP
U.S. Class: 514/266.1; 544/277; 544/287
Field Of Search: ;514/266.1; ;544/277; ;544/287
International Class: A61K 31/517
U.S Patent Documents:
Foreign Patent Documents: 0 525 960; 0 525 960; 0 525 960; 0 675 124; 0 675 124; 0 675 124; 0 716 857; 0 716 857; 0 716 857; 0 884 310; 0 884 310; 0 884 310; 0 900 568; 0 900 568; 0 900 568; 1356763; 1356763; 2 017 097; 2017097; 55-118917; 55 118917; 55-118918; 55 118918; 56-002322; 56 002322; WO-93/21259; WO-93/21259; WO-94/17090; WO-94/17090; WO-95/24379; WO-95/24379; WO-96/04923; WO-96/04923; WO-96/25488; WO-96/25488; WO-96/32478; WO-96/32478; WO-97/34631; WO-97/34631; WO-97/41097; WO-97/41097; WO-97/43276; WO-97/43276; WO-97/46688; WO-97/46688; WO-98/33802; WO-98/33802; WO-98/38173; WO-98/38173; WO-99/08501; WO-99/08501; WO-99/08501; WO-99/34804; WO-99/34804; WO-01/00881; WO-01/00881; WO-01/3076; WO-01/30768; WO-01/30768; WO-01/53266; WO-01/53266; WO-01/57034; WO-01/57034; WO-01/81346; WO-01/81346; WO-01/81346; WO-03/035075; WO-03/035075; WO-03/106622; WO-03/106622; WO-03/106622; WO-2004/007491; WO-2004/007491; WO-2004/012768; WO-2004/012768; WO-2004/026285; WO-2004/026285; WO-2004/026285; WO-2004/029055; WO-2004/029055; WO-2004/052373; WO-2004/052373; WO-2004/056820; WO-2004/056820; WO-2004/089925; WO-2004/089925; WO-2004/108708; WO-2004/108708; WO-2004/108709; WO-2004/108709; WO-2004/108713; WO-2004/108713; WO-2004-108713; WO-2004/108715; WO-2004/108715; WO-2004-108715; WO-2005/016348; WO-2005/016348; WO-2005/016349; WO-2005/016349; WO-2005/067901; WO-2005/067901; WO-2005-067901; WO-2005/120511; WO-2005/120511; WO-2009/058361; WO-2009/058361; WO-2010/065923; WO-2010/065923; WO-2010-065923; WO-2010/123931; WO-2010/123931
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Abstract: The invention provides a class of substituted quinazolinone compounds and methods of treating diseases mediated by PI3K.delta. activity. The disclosed compounds are useful in treating diseases such as bone-resorption disorders; and cancer, especially hematopoietic cancers, lymphomas, multiple myelomas and leukemia. The compounds are also useful in disrupting or inhibiting cellular processes such as leukocyte function or accumulation, neutrophils function, lymphocyte proliferation, and endogenous immune responses.
Claim: What is claimed is:

1. A compound of the formula: ##STR00183## .[.(S)-5-fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)-propyl]-3H-quinazolin-- 4-one,.]. or a pharmaceutically acceptable saltthereof.

2. A pharmaceutical composition comprising a compound according to claim 1 and at least one pharmaceutically acceptable excipient.
Description:
 
 
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