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Method for carrying out a chemical reaction
8709361 Method for carrying out a chemical reaction
Patent Drawings:

Inventor: Gueller, et al.
Date Issued: April 29, 2014
Application:
Filed:
Inventors:
Assignee:
Primary Examiner: Warden; Jill
Assistant Examiner:
Attorney Or Agent: Husch Blackwell LLP
U.S. Class: 422/547; 422/552; 434/298
Field Of Search: ;422/547; ;422/552; ;436/174; ;434/298
International Class: B01L 3/00
U.S Patent Documents:
Foreign Patent Documents: 24 33 616; 4118538; 44 19 759; WO 96/28248; WO 97/31217; WO 98/10866; WO 98/57738
Other References: International Search Report for International Application No. PCT/CH01/00485, Oct. 22, 2001. cited by applicant.









Abstract: Eight containers (1) containing substances (602, 702) are held in holes (71) in a support (70). The eight containers (1) containing different substances or the same substances in different amounts graduated in mole equivalents form a set (69) of containers containing substances, which set can be used for carrying out a chemical reaction.
Claim: The invention claimed is:

1. A method for carrying out a chemical reaction between at least a first substance and a second substance, comprising: providing a premetered amount of the firstsubstance and a premetered amount of the second substance which is the molar equivalent of the premetered amount of the first substance or is graduated thereto based on mole equivalents, wherein a first premetered amount of the first substance is presentin a first container, which is sealed air-tight, and a second premetered amount of the first substance which is the molar equivalent of the first premetered amount of the first substance or is graduated thereto based on mole equivalents is present in asecond container, which is sealed air-tight, and providing at least one third container with the premetered amount of the second substance which is the molar equivalent of the premetered amount of the first substance or is graduated thereto based on moleequivalents; and substantially completely releasing the first and second premetered amounts of the first substance from said first and second containers and substantially completely using said first substance in the reaction between at least the firstsubstance and the second substance.

2. The method as claimed in claim 1, wherein the chemical reaction is one of at least two reactions carried out in parallel; and wherein, in each of the at least two reactions, a substance is released from at least one container, which issealed air-tight and contains a premetered amount of the substance that is released from said at least one container, and the substance which is released from said at least one container is used in the respective reaction.

3. The method as claimed in claim 2, wherein the at least two reactions differ from each other in at least one respect, the at least one respect being selected from a group consisting of reaction conditions, a substance used, and an amount of asubstance used.

4. The method as claimed in claim 1 wherein the chemical reaction is a chemical or biochemical synthesis method.

5. The method as claimed in claim 4 wherein a product is prepared which is not a polymer.

6. The method as claimed in claim 1, wherein at least one of the substances is released by at least partial, irreversible elimination of the air-tight seal of at least one of the containers, directly where the reaction takes place.

7. The method as claimed in claim 1, wherein at least one of the first or second substances is released by at least partial, irreversible elimination of the air-tight seal of at least one of the containers and then added to at least one furthersubstance.

8. The method as claimed in claim 6 or 7, wherein the at least partial elimination of the air-tight seal of the at least one of the containers is effected by nontargeted use of a chemical, physical or mechanical effect.

9. The method as claimed in claim 1 wherein the premetered amounts are 1, 2, 5, 10, 20, 50, 100, 200, 500, 1000, 2000, 5000, 10,000, 20,000, 50,000, 100,000, 200,000, 500,000, 1,000,000, 2,000,000, 5,000,000, 10,000,000, 20,000,000, 50,000,000,or 1,000,000,000 nmol.

10. The method as claimed in claim 1, wherein the second container comprises a second premetered amount of the first substance which is graduated relative to the first premetered amount of the first substance based on mole equivalents.

11. The method as claimed in claim 10, wherein the second premetered amount of the first substance is an integral multiple of the first premetered amount of the first substance.

12. The method as claimed in claim 1, further comprising providing at least one fourth container with a premetered amount of the second substance which is graduated relative to the premetered amount of the second substance in the thirdcontainer based on mole equivalents.

13. The method as claimed claim 1, further comprising at least one further container with a premetered amount of a third substance which is the molar equivalent of the premetered amount of the first substance or is graduated thereto based onmole equivalents.

14. The method as claimed in claim 1, wherein the first container has x nmol of substance and the at least one third container has yx/1000 nmol of substance, where x and y are integers and y is a number from 1001 to 1,000,000.

15. A set of containers containing substances, which comprises at least one first container with a first premetered amount of a first substance, the first container being irreversibly-openable airtight sealed, at least one second container witha second premetered amount of the first substance which is graduated relative to the first premetered amount based on mole equivalents, the second container being irreversibly-openable air-tight sealed and at least one third container with a premeteredamount of a second substance which is the molar equivalent of the first premetered amount or of an integral multiple thereof.

16. The set as claimed in claim 15, wherein the premetered amounts of the first or second or further substances in further containers are in each case molar equivalent amounts of the premetered amount of the first substance in the firstcontainer, or integral multiples thereof.

17. The set as claimed in claim 16, wherein at least one of the substances is a pure chemical compound.

18. The set as claimed in claim 15 further comprising at least one fourth container with a premetered amount of the second substance which is graduated relative to the premetered amount of the second substance in the third container based onmole equivalents.

19. The set as claimed in claim 15, wherein the at least one first container contains x nmol of the first substance and the at least one second container contains yx/1000 nmol of the first substance, where x and y are integers and y is a numberfrom 1001 to 1,000,000.

20. The set as claimed in claim 19, wherein y is 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000 or 10,000.

21. The set as claimed in claim 19, wherein x is 1, 2, 5, 10, 20, 50, 100, 200, 500, 1000, 2000, 5000, 10,000, 20,000, 50,000, 100,000, 200,000, 500,000, 1,000,000, 2,000,000, 5,000,000, 10,000,000, 20,000,000, 50,000,000, or 1,000,000,000.

22. The set as claimed in claim 15 comprising at least three containers with different substances.

23. The set as claimed in claim 22, comprising in addition to the containers with different substances in each case at least one further container with the same substance in an amount graduated relative to the first premetered amount of therespective substance based on mole equivalents.

24. The set as claimed in claim 15, wherein at least one of the containers does not contain a molar solution.

25. The set as claimed in claim 15, wherein, in the containers, any space not filled with the substance is substantially completely filled with a gas, a mixture of gases or a liquid, which gas, mixture or liquid contains less than 1% ofO.sub.2.

26. The set as claimed in claim 15, wherein, in at least one of the containers, the space not filled with substance is substantially completely filled with an inert gas.

27. The set as claimed in claim 15, wherein the substance in at least one of the containers is a catalyst, inhibitor, initiator or an accelerator.

28. The set as claimed in claim 15, wherein the containers are sealed air-tight, the air-tight seal of the containers being capable of being at least partly irreversibly eliminated.

29. The set as claimed in claim 15, wherein the containers have a container wall thickness of from 0.02 mm to 0.3 mm.

30. The set as claimed in claim 15, wherein the largest diameter of the containers are of the same magnitude.

31. The set as claimed in claim 15, wherein the containers are provided with a substance designation or quantity specification.

32. The set as claimed in claim 15, wherein a plurality of containers is arranged in a matrix which, for carrying out a plurality of chemical reactions, can be mounted directly on a matrix of reaction vessels or an automatic laboratoryapparatus, the containers in the matrix being capable of being transported individually, together or group by group into the reaction vessels.

33. The set as claimed in claim 15, wherein at least one of the substances is a mixture of characterized chemical compounds.
Description:
 
 
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