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Energetic modulation of nerves
8517962 Energetic modulation of nerves
Patent Drawings:Drawing: 8517962-10    Drawing: 8517962-11    Drawing: 8517962-12    Drawing: 8517962-13    Drawing: 8517962-14    Drawing: 8517962-15    Drawing: 8517962-16    Drawing: 8517962-17    Drawing: 8517962-18    Drawing: 8517962-19    
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Inventor: Gertner, et al.
Date Issued: August 27, 2013
Application:
Filed:
Inventors:
Assignee:
Primary Examiner: Chen; Tse
Assistant Examiner: Remaly; Mark
Attorney Or Agent: Vista IP Law Group, LLP
U.S. Class: 601/2; 600/437; 600/443; 600/459; 601/3; 601/4
Field Of Search: 600/407; 600/408; 600/409; 600/410; 600/411; 600/412; 600/413; 600/414; 600/415; 600/416; 600/417; 600/418; 600/419; 600/420; 600/421; 600/422; 600/423; 600/424; 600/425; 600/426; 600/427; 600/428; 600/429; 600/430; 600/431; 600/432; 600/433; 600/434; 600/435; 600/436; 600/437; 600/438; 600/439; 600/440; 600/441; 600/442; 600/443; 600/444; 600/445; 600/446; 600/447; 600/448; 600/449; 600/450; 600/451; 600/452; 600/453; 600/454; 600/455; 600/456; 600/457; 600/458; 600/459; 600/460; 600/461; 600/462; 600/463; 600/464; 600/465; 600/466; 600/467; 600/468; 600/469; 600/470; 600/471; 600/472; 600/473; 600/474; 600/475; 601/2; 601/3; 601/4
International Class: A61B 5/05
U.S Patent Documents:
Foreign Patent Documents: 0225120; 0679371; 1265223; 1579889; 1847294; WO 9731364; WO 9948621; WO 0072919; WO 0134018; WO 02069805; WO 2005030295; WO 2006129099; WO 2008144274; WO 2009018351; WO 2009018394; WO 2011053757; WO 2011053772
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Abstract: A system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.
Claim: The invention claimed is:

1. A system for treatment, comprising: a focused ultrasound energy source for placement outside a patient; wherein the focused ultrasound energy source is configuredto deliver ultrasound energy from outside the patient towards a region inside the patient containing one or more nerves that are parts of an autonomic nervous system inside the patient, the one or more nerves surrounding a blood vessel; wherein thefocused ultrasound energy source is configured to deliver the ultrasound energy to a plurality of locations sequentially around a reference location; wherein the system further comprises a processor configured to (1) determine a coordinate of thereference location, (2) use the coordinate of the reference location to compute a first coordinate for one of the plurality of locations that has a probability of including the one or more nerves, and (3) compute a second coordinate for another one ofthe plurality of locations that has a probability of including the one or more nerves; and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy to the plurality of locations sequentially around the referencelocation by delivering the ultrasound energy to the one of the plurality of locations, and delivering the ultrasound energy to the other one of the plurality of locations.

2. The system of claim 1, wherein the focused ultrasound energy source comprises a transducer, and an angle of the focused ultrasound source is anywhere between 30 degrees to 80 degrees with respect to a line traveling down a center of thetransducer relative to a line connecting the transducer to the blood vessel.

3. The system of claim 1, wherein the focused ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the one or more nerves.

4. The system of claim 1, wherein the focused ultrasound energy source is configured to deliver the ultrasound energy to the one or more nerves from multiple directions outside the patient while the focused ultrasound energy source isstationary relative to the patient.

5. The system of claim 1, wherein the processor is configured for determining a position of the blood vessel as the coordinate of the reference location.

6. The system of claim 5, wherein the processor is configured to receive information from a CT device, a MRI device, a thermography device, an infrared imaging device, an optical coherence tomography device, a photoacoustic imaging device, aPET imaging device, a SPECT imaging device, or an ultrasound device.

7. The system of claim 1, wherein the processor is configured to determine the coordinate of the reference location using a Doppler triangulation technique.

8. The system of claim 1, wherein the focused ultrasound energy source is configured to deliver the ultrasound energy to decrease a sympathetic stimulus to the kidney, decrease an afferent signal from the kidney to an autonomic nervous system,or both.

9. The system of claim 1, wherein the focused ultrasound energy source has an orientation so that the focused ultrasound energy source aims at a direction that aligns with the blood vessel.

10. The system of claim 1, wherein the focused ultrasound energy source is configured to track a movement of the one or more nerves.

11. The system of claim 10, wherein the focused ultrasound energy source is configured to track the movement of the one or more nerves by tracking a movement of the blood vessel.

12. The system of claim 1, further comprising: a device for placement inside the patient; wherein the processor is configured for determining the coordinate of the reference location using the device.

13. The system of claim 12, wherein the device is for insertion into the blood vessel.

14. The system of claim 1, wherein the focused ultrasound energy source is oriented to deliver the ultrasound energy towards the blood vessel at an angle anywhere between -10 degrees and -48 degrees relative to a horizontal line connectingtransverse processes of a spinal column, the angle directed from a lower torso to an upper torso of the patient.

15. A system for treatment of one or more nerves next to a blood vessel comprising: an ultrasound energy source for placement outside a patient; wherein the ultrasound energy source is configured to deliver ultrasound energy from outside thepatient to a plurality of locations inside the patient; wherein the system further comprises a processor configured to (1) determine a coordinate of a reference location, (2) use the coordinate of the reference location to compute a first coordinate forone of the plurality of locations that has a probability of including the one or more nerves, and (3) compute a second coordinate for another one of the plurality of locations that has a probability of including the one or more nerves; and wherein theultrasound energy source is configured to deliver the ultrasound energy to the plurality of locations sequentially by delivering the ultrasound energy to the one of the plurality of locations, and delivering the ultrasound energy to the other one of theplurality of locations.

16. The system of claim 15, wherein the ultrasound energy source is configured to provide the ultrasound energy to achieve partial ablation of the one or more nerves.

17. The system of claim 15, wherein the ultrasound energy source is configured to deliver the ultrasound energy to the one or more nerves from multiple directions outside the patient while the ultrasound energy source is stationary relative tothe patient.

18. The system of claim 15, wherein the processor is configured for determining a position of the blood vessel as the reference location.

19. The system of claim 18, wherein the processor is configured to receive information from a CT device, a MRI device, a thermography device, an infrared imaging device, an optical coherence tomography device, a photoacoustic imaging device, aPET imaging device, a SPECT imaging device, or an ultrasound device.

20. The system of claim 18, wherein the processor is configured to determine the coordinate of the reference location using a Doppler triangulation technique.

21. The system of claim 15, wherein the ultrasound energy source is configured to deliver the ultrasound energy to decrease a sympathetic stimulus to the kidney, decrease an afferent signal from the kidney to an autonomic nervous system, orboth.

22. The system of claim 15, wherein the ultrasound energy source has an orientation so that the ultrasound energy source aims at a direction that aligns with the blood vessel.

23. The system of claim 15, wherein the ultrasound energy source is configured to track a movement of the one or more nerves.

24. The system of claim 23, wherein the ultrasound energy source is configured to track the movement of the one or more nerves by tracking a position of the blood vessel.

25. The system of claim 15, further comprising: a device for placement inside the patient; wherein the processor is configured for determining the coordinate of the reference location using the device.

26. The system of claim 25, wherein the device is for insertion into the blood vessel.

27. The system of claim 15, wherein the ultrasound energy source is oriented to deliver the ultrasound energy towards the blood vessel at an angle anywhere between -10 degrees and -48 degrees relative to a horizontal line connecting transverseprocesses of a spinal column, the angle directed from a lower torso to an upper torso of the patient.

28. The system of claim 15, wherein the ultrasound energy source comprises a transducer, and an angle of the ultrasound energy source is anywhere between 30 degrees to 80 degrees with respect to a line traveling down a center of the transducerrelative to a line connecting from the transducer to the blood vessel.
Description:
 
 
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