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Method for treatment of premature ejaculation in humans
7754767 Method for treatment of premature ejaculation in humans
Patent Drawings:Drawing: 7754767-2    Drawing: 7754767-3    Drawing: 7754767-4    
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Inventor: Singh
Date Issued: July 13, 2010
Application: 10/482,629
Filed: November 6, 2003
Inventors: Singh; Chandra U. (San Antonio, TX)
Assignee: Trinity Laboratories, Inc. (San Antonio, TX)
Primary Examiner: Padmanabhan; Sreeni
Assistant Examiner: Ramachandran; Umamaheswari
Attorney Or Agent: Kumar; Nanda P.B.A.Reed Smith LLP
U.S. Class: 514/569; 514/159; 514/210.21; 514/256; 514/289; 514/410; 514/420; 514/570
Field Of Search: 514/569; 514/256; 514/210.21; 514/289; 514/159; 514/420; 514/570; 514/410
International Class: A01N 37/10; A01N 37/36; A61K 31/00; A61K 31/40; C07D 239/42; A01N 43/38; A01N 43/42; A01N 43/54
U.S Patent Documents:
Foreign Patent Documents:
Other References: Mitchell et al. (Proc Natl Acad Sci 90, 11693-97, 1994). cited by examiner.
Mandell et al. (J Clin Pharamacol. Jun. 1995 3596), 588-93) Abstract only. cited by examiner.
Oshman and Mirisola document (http://www.oshmanlaw.com/ pharmaceutical.sub.--litigation/quinine.asp). cited by examiner.
Dextromethorphan (http://www.drugs.com/dextromethorphan.html?printable=1. cited by examiner.
Abdel-Hamid et al (Intl. J of Impotence Research, Jan. 2001, 13, 41-45). cited by examiner.
Jetter, Clin Pharmaol Ther 2002, 71(1), 21-9), Abstract. cited by examiner.
"Phosphodieseterase-5 inhibitors for Erectile Dysfunction" , p. 1-4. cited by examiner.









Abstract: The present invention belongs to the fields of pharmacology, medicine and medicinal chemistry, and provides methods and compositions for treating sexual dysfunction; more particularly, the invention relates to treatment of premature ejaculation in humans.
Claim: What is claimed is:

1. A method for delaying the onset of ejaculation in a male individual, comprising administering to the individual a pharmaceutical formulation consisting essentially ofdextromethorphan, sildenafil, and acetaminophen in an amount effective to delay the onset of ejaculation by the individual during sexual intercourse, wherein said administration is oral, parenteral or by intracavernosal injection.

2. The method of claim 1, wherein said administration is parenteral.

3. The method of claim 1, wherein said administration is by intracavernosal injection.

4. A method for delaying the onset of ejaculation in a male individual who has a premature ejaculation problem, comprising administering to the individual a pharmaceutical formulation consisting essentially of a combination of sildenafil,dextromethorphan, and acetaminophen in an amount effective to delay the onset of ejaculation by the individual during sexual intercourse, wherein the formulation is administered orally, parenterally or by intracavernosal injection.

5. The method of claim 4, wherein the formulation is administered parenterally.

6. The method of claim 4, wherein the formulation is administered by intracavernosal injection.

7. The method of claim 4, wherein the sildenafil, dextromethorphan, and acetaminophen are administered combined in a single dosage form.

8. The method of claim 1, wherein the pharmaceutical formulation consists of dextromethorphan, sildenafil and acetaminophen in an amount effective to delay the onset of ejaculation by the individual during sexual intercourse, and apharmaceutically acceptable carrier or excipient.

9. The method of claim 4, wherein the pharmaceutical formulation consists of dextromethorphan, sildenafil and acetaminophen in an amount effective to delay the onset of ejaculation by the individual during sexual intercourse, and apharmaceutically acceptable carrier or excipient.
Description:
 
 
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