| Patent Number |
Title Of Patent |
Date Issued |
| RE38200 |
Indole-2,3-dione-3-oxime derivatives |
July 22, 2003 |
| The present invention relates to novel indole-2,3-dione-3-oxime derivatives capable of antagonising the effect of excitatory amino acids, such as glutamate. More specifically the novel indole-2,3-dione-3-oxime derivatives of the invention may be described by general formula (I), wher |
| 7288653 |
Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
October 30, 2007 |
| This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment of alleviation of diseases or disorders associated with, or mediated by a drop in extra cellular pH. |
| 6936613 |
Benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
August 30, 2005 |
| The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are respons |
| 6727260 |
Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders |
April 27, 2004 |
| This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment of alleviation of diseases or disorders associated with, or mediated by a drop in extra cellular pH. |
| 6710044 |
Technical field |
March 23, 2004 |
| Chemical compounds of the formula ##STR1##as well as pharmaceutical compositions containing them and methods for their use in the treatment of disorders and diseases responsive to modulation of the GABA.sub.A receptor complex of the central nervous system, such disorders and diseases |
| 6703391 |
Quinoxalinedione derivatives, their preparation and use |
March 9, 2004 |
| A compound having the formula ##STR1##or a pharmaceutically acceptable salt thereof wherein R is hydrogen or hydroxy; R.sup.1 is hydrogen, alkyl, arylalkyl, (CH.sub.2).sub.n OH, or (CH.sub.2).sub.n NR.sup.7 R.sup.8 ; R.sup.5 and R.sup.6 are each independently hydrogen, |
| 6693111 |
Indole-2,3-dione-3-oxime derivatives |
February 17, 2004 |
| Indole-2,3-dione-3-oxime derivatives, for instance compounds represented by the formula ##STR1##are capable of antagonizing the effect of excitatory amino acids, such as glutamate. Also disclosed are methods of preparing the compounds, pharmaceutical compositions comprising them, and |
| 6649609 |
Benzimidazole derivatives and pharmaceutical compositions comprising these compounds |
November 18, 2003 |
| The present invention relates to novel 1-phenylbenzimidazole derivatives having particular alkoxycarbonyl substituents in the 5-position of the benz ring and having particular cyclic substituents in the meta-position of the phenyl ring, as well as to pharmaceutical compositions containin |
| 6503925 |
1-phenyl-benzimidazole compounds and their use as GABA-A receptor modulators |
January 7, 2003 |
| Chemical compounds of the formula ##STR1##as well as pharmaceutical compositions containing them and methods for their use in the treatment of disorders and diseases responsive to modulation of the GABA.sub.A receptor complex of the central nervous system, such disorders and diseases |
| 6395748 |
Tropane-derivatives, their preparation and use |
May 28, 2002 |
| Compounds of formula (a), (b), (c), or (d), or any mixture thereof, or a pharmaceutically-acceptable salt thereof; ##STR1##wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R.sup.3 is --CH.sub.2 --X--R', wherein X is O, S or NR", wherein R |
| 6376673 |
Piperidine derivatives as neurotransmitter re-uptake inhibitors |
April 23, 2002 |
| The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof; wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R.sup.3 is --CR'.dbd.NOR" wherein R' and R" each independently are hydrogen, alkyl, |
| 6288079 |
Tropane-derivatives, their preparation and use |
September 11, 2001 |
| Compounds of formula (a), (b), (c), or (d), or any mixture thereof, or a pharmaceutically-acceptable salt thereof; ##STR1##wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or 2-hydroxyethyl; R.sup.3 is --CH.sub.2 --X--R', wherein X is O, S or NR", wherein R |
| 6239128 |
Indole-2,3-dione-3-oxime derivatives for therapeutic use |
May 29, 2001 |
| The present invention relates to the use of indole-2,3-dione-3-oxime derivatives in a method of combating diseases and disorders associated with or mediated by the release of excitatory amino acids. |
| 6218547 |
1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators |
April 17, 2001 |
| The present invention relates to novel benzimidazole compounds, represented by general formula (I) in which o is 0, 1, 2 or 3; R.sup.1 represents an alkyl group, a phenyl group, or a monocyclic heterocyclic group, which groups may be substituted one or more times with substituents select |
| 6124285 |
Indole-2,3-dione-3-oxime derivatives |
September 26, 2000 |
| The present invention relates to novel indole-2,3-dione-3-oxime derivatives capable of antagonising the effect of excitatory amino acids, such as glutamate. More specifically the novel indole-2,3-dione-3-oxime derivatives of the invention may be described by general formula (I), wher |
| 5922725 |
Benzimidazole compounds and their use as modulators of the GABA.sub.A receptor complex |
July 13, 1999 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is pheny |
| 5922724 |
Benzimidazole compounds and their use as modulators of the GABA a receptor complex |
July 13, 1999 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is pheny |
| 5917053 |
Indole-2,3-dione-3-oxime derivatives, their preparation and use |
June 29, 1999 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1, X and R.sup.5 have the meanings set further in the specification.A is a ring of five to seven atoms fused with the benzo ring at the positions |
| 5902813 |
Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use |
May 11, 1999 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sub.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is pheny |
| 5843945 |
AMPA antagonists and a method of treatment |
December 1, 1998 |
| The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n |
| 5801174 |
Fused indole and quinoxaline derivatives, their preparation and use |
September 1, 1998 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof whereinR.sup.1 is hydrogen, alkyl or benzyl;X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl;Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; |
| 5780493 |
AMPA antagonists and method of treatment therewith |
July 14, 1998 |
| The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n |
| 5736556 |
Tropane-2-aldoxime derivatives as nevro transmitter reuptake inhibitors |
April 7, 1998 |
| The present invention discloses compounds of the formula, ##STR1## any mixture thereof, or a pharmaceutically acceptable salt thereof; wherein R, R.sup.3, and R.sup.4 each have the meanings set forth in the specification.The compounds possess valuable pharmaceutical properties as mon |
| 5565580 |
Glutamate Antagonists |
October 15, 1996 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof whereinone R.sup.21 and R.sup.22 is alkyl and the other is hydrogen or both of R.sup.21 and R.sup.22 are hydrogen;and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, |
| 5554632 |
Benzimidazole compounds |
September 10, 1996 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central n |
| 5554630 |
Benzimidazole compounds |
September 10, 1996 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central n |
| 5478859 |
Indole-derivatives, method of treatment therewith, and pharmaceutical compositions comprising su |
December 26, 1995 |
| The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.21 and R.sup.22 each independently are alkyl; andR.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.11, R.sup.12, R.sup.13, and R.sup.14 each independentl |
| 5436250 |
Isatineoxime derivatives, their preparation and use |
July 25, 1995 |
| A compound having the formula ##STR1## wherein R.sup.4 and R.sup.5 independently are hydrogen, halogen, CF.sub.3, CN, NO.sub.2 or SO.sub.2 NR.sup.1 R.sup.2 whereinR.sup.1 is hydrogen or C.sub.1-6 -alkyl which may be straight, branched or cyclic,R.sup.2 is hydrogen or C.sub.1-6 -alkyl |
| 5356912 |
3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease |
October 18, 1994 |
| Novel azacyclic compounds selected from the group consisting of ##STR1## wherein R.sup.1 is H or C.sub.1-6 -alkylR.sup.3 is ##STR2## R" is H or C.sub.1-8 -alkyl or C.sub.1-6 -alkoxy or C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl or aryl, andR.sup.4 is H, C.sub.1-8 -alkyl or Cl;and a salt |
| 5270306 |
Method of antagonizing excitatory amino acids by administration of imidazobenzodiazepine compoun |
December 14, 1993 |
| A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization comprising the step of administering to said subject an effective amount of a compound having the formula ##STR1## wherein R.sup.3 is hydrogen, C.sub.1-8 -alkyl |
| 5262427 |
3-substituted and optionally 1-substituted azacyclic or azabicyclic compounds, pharmaceutical co |
November 16, 1993 |
| Azacyclic compounds selected from the group consisting of ##STR1## wherein R.sup.1 is H or C.sub.1-6 -alkylR.sup.3 is ##STR2## wherein R' is C.sub.3-8 -alkyl, cyclopropyl, C.sub.4-8 -cycloalkyl, benzyl which may be substituted, or C.sub.1-4 -alkoxy-C.sub.1-4 -alkyl, andR" is H or |
| 5242918 |
Isatinoxime derivatives, their preparation and use |
September 7, 1993 |
| A compound having the formula ##STR1## wherein R.sup.4 and R.sup.5 independently are hydrogen, halogen, CF.sub.3, CN, NO.sub.2 or SO.sub.2 NR.sup.1 R.sup.2 whereinR.sup.1 is hydrogen or straight, C.sub.1-6 -alkyl which may be branched or cyclic,R.sup.2 is hydrogen or straight, C.sub. |
| 5223527 |
Isatineoxime derivatives and their use |
June 29, 1993 |
| A compound having the formula ##STR1## wherein R.sup.1 is C.sub.1-6 -alkyl which may be branched or cyclic;R.sup.2 is C.sub.1-6 -alkyl which may be branched or cyclic; or wherein R.sup.1 and R.sup.2 together represent --(CH.sub.2).sub.n --, wherein n is 3, 4, 5.and a method of treati |
| 5200422 |
Benzimidazole derivatives, their preparation and use |
April 6, 1993 |
| A compound having the formula ##STR1## wherein R.sup.1 is hydrogen, NH.sub.2 or C.sub.1-6 -alkyl which may be branched;X is O, S, NCN;Y is O, S;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkoxy |
| 5198461 |
Isatine derivatives, their preparation and use |
March 30, 1993 |
| A method of treatment with compounds having the formula ##STR1## R.sup.1 is hydrogen, C.sub.1-6 -alkyl which may be branched, C.sub.3-7 -cycloalkyl, benzyl, phenyl which may be substituted, acyl, hydroxy, C.sub.1-6 -alkoxy, CH.sub.2 CO.sub.2 R' wherein R' is hydrogen or C.sub.1-6 |
| 5164404 |
Hydrazone derivatives and their use |
November 17, 1992 |
| A method of antagonizing the biological effects of an excitatory amino acid of a subject in need of such antagonization, comprising the step of administering to said subject an effective excitatory amino acid antagonizing amount of an indole-2,3-dione-3-hydrazone derivative, is discl |
| 5116841 |
Imidazoquinoxalines and their preparation and use |
May 26, 1992 |
| New imidazoquinoxaline compounds having the general formula I ##STR1## wherein ##STR2## wherein R.sup.1 and R.sup.2 independently are hydrogen, straight or branched C.sub.1-6 -alkyl, or C.sub.3-7 -cycloalkyl; R.sup.3 is hydrogen, straight or branched C.sub.1-6 -alkyl, straigh |
| 5102885 |
Imidazoquinoxaline compounds and their use |
April 7, 1992 |
| New imidazoquinoxaline compounds having the general formula I ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, straight or branched C.sub.1-6 -alkyl, or C.sub.3-7 -cycloalkyl; R.sup.3 is hydrogen, straight or branched C.sub.1-6 -alkyl, straight or branched C.sub.2-6 |
| 5075304 |
Imidazoquinoxaline compounds and their preparation and use |
December 24, 1991 |
| New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## or CO.sub.2 R' wherein R' isC.sub.3-7 -cycloalkyl;R.sup.5 is methyl, which is substituted with hydrogen, alkoxycarbonyl, heteroaryl, morpholino, C.sub.3-7 -cycloalkyl, C.sub.1-6 -alke |
| 5034530 |
Imidazoquinoxaline compounds and their preparation and use |
July 23, 1991 |
| New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## wherein R' is C.sub.1-6 -alkyl, which may be straight or branched, C.sub.3-7 -cycloalkyl or phenyl; andR.sup.4 is hydrogen or C.sub.1-6 -alkyl; and 5-N-oxides thereof.The compounds a |
| 4999354 |
Imidazoquinoxaline compounds and their preparation and use |
March 12, 1991 |
| New imidazoquinoxaline compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl; and--A-- is ##STR3## wherein R.sup.5 is hydrogen or halogen.The compounds are useful in psy |
| 4999353 |
Chemical process for the preparation of imidazo-quinoxalines and intermediates for use in the pr |
March 12, 1991 |
| The invention relates to a dealkylation chemical process for preparing imidazoquinoxalines bearing hydrogen substitution in the five position, and to valuable pharm-intermediates of the formula I ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, |
| 4968682 |
Imidazoquinoxaline compounds and their preparation and use |
November 6, 1990 |
| New imidazoquinoxaline compounds having the general formula ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl; and ##STR3## wherein R.sup.5 is hydrogen or halogen. The compounds are useful in psychopharmaceutica |
| 4933353 |
Lipophilically-substituted piperidine oxadiazolyl compounds and their use in stimulating cogniti |
June 12, 1990 |
| New piperidine compounds having the formula ##STR1## wherein at least one of R.sup.3, R.sup.4, and R.sup.5 are ##STR2## and the other independently are H, C.sub.1-6 -alkyl, wherein R' is H, C.sub.1-8 -alkyl, phenyl, thienyl, cyclopropyl, or C.sub.1-3 -alkoxymethyl; andR.sup. |
| 4902686 |
Tricyclic heterocyclic compounds and their use in treating benzodiazepin receptor-related ailmen |
February 20, 1990 |
| New heterocyclic compounds having the general formula ##STR1## wherein R.sup.3 is ##STR2## CO.sub.2 R' or CONR'R", wherein R' and R" independently are C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl;--A-- is --C(.dbd.O)--NR'"--, --NR'"--C(.dbd.O)--, or ##S |
| 4886797 |
Heterocyclic compounds and their preparation and use |
December 12, 1989 |
| New heterocyclic derivatives having the general formula: ##STR1## wherein X is ##STR2## or CO.sub.2 R' wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, or C.sub.1-3 -alkoxymethyl, and--A-- is --(CH.sub.2).sub.n --Y--(CH.sub.2).sub.m --,wherein n and m are 0 or 1 and --Y-- |
| 4880799 |
Heterocyclic compounds and their preparation and use |
November 14, 1989 |
| New heterocyclic derivatives havingy the general formula: ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, or C.sub.1-3 -alkoxymethyl, and--A-- is --(CH.sub.2).sub.n --Y--(CH.sub.2).sub.m --,wherein n and m are O or 1 and --Y-- is --O--, --S--, --C |
| 4870073 |
Heterocyclic compounds and their preparation and use |
September 26, 1989 |
| New heterocyclic derivatives having the general formula: ##STR1## wherein X is ##STR2## or CO.sub.2 R' whereinR' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl, or C.sub.1-3 -alkoxymethyl, andA-- is --(CH.sub.2).sub.n --Y--(CH.sub.2).sub.m --,wherein n and m are 0 or 1 and --Y-- is |
| 4866065 |
Imidazothienopyrimidines useful in psychopharmaceutical preparations |
September 12, 1989 |
| New heterocyclic compounds having the general formula ##STR1## wherein ##STR2## wherein R' is C.sub.1-6 -alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxymethyl;R.sup.4 is C.sub.1-6 -alkyl;--S-- is ##STR3## and wherein R.sup.5 and R.sup.6 independently are hydrogen, C.sub |
| 4845095 |
4-phenylpiperidine compounds and their use |
July 4, 1989 |
| Piperidine compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, (C.sub.1-6 -alkoxyaryl)alkyl, diphenylmethozy-C.sub.1-6 -alkyl, C.sub.1-8 -alkyl, C.sub.4-10 -cycloalkylalkyl, phenoxy-C.sub.1-8 -alkyl, or C.sub.1-6 -alkoxy-C.sub.1-6 -alkyl; andR is ##STR2## o |
