| Patent Number |
Title Of Patent |
Date Issued |
| 7052858 |
Diagnostic assays for detection of Cryptosporidium parvum |
May 30, 2006 |
| This invention provides a novel Cryptosporidium parvum protein disulfide isomerase polypeptide, and nucleic acids that encode this polypeptide. The invention also provides methods, reagents, and kits that are useful for diagnosing infection by Cryptosporidium parvum. The methods are base |
| 6908739 |
Diagnostic assays for detection of Giardia lamblia |
June 21, 2005 |
| This invention provides methods, reagents, and kits that are useful for diagnosing infection by Giardia lamblia. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the .alpha.-1-giardin antigen of G. lamblia. |
| 6828110 |
Assays for detection of Bacillus anthracis |
December 7, 2004 |
| This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis. |
| 6777190 |
Crosstalk inhibitors and their uses |
August 17, 2004 |
| Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample. The assay includes the steps of providing at least one crosstalk inhibitor. This inhibitor, u |
| 6503722 |
Diagnostic tests and kits for Clostridium difficile |
January 7, 2003 |
| This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile detection that involve assaying for both C. difficile glutamate dehydrogenase and C. difficile |
| 6348318 |
Methods for concentrating ligands using magnetic particles |
February 19, 2002 |
| This invention provides methods, compositions and kits for concentrating target ligands, including microorganisms, from samples, including biological samples. The methods involve the use of magnetic particles to concentrate the target analytes. Also provided are methods, compositions |
| 6302919 |
Reverse-flow centrifugal filtration method |
October 16, 2001 |
| A filtration device, apparatus, and method of filtration useful for filtering liquid samples are disclosed wherein filtration occurs opposite the direction of centrifugal force. The filtration device is placed within a container that contains the liquid sample to be filtered. Together, t |
| 6297060 |
Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorb |
October 2, 2001 |
| Devices for use in heterogeneous ligand-receptor assays, having a porous member in contact with a nonabsorbent textured surface, where the surface texturing is such that a capillary network is formed when in fluid communication with the porous member. More particularly, these devices |
| 6207395 |
Diagnostic assays for detection of Entamoeba histolytica |
March 27, 2001 |
| This invention provides methods, reagents, and kits that are useful for diagnosing infection by E. histolytica. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, that bind to the 29 kDa antigen of E. histolytica. |
| 5985579 |
Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor ass |
November 16, 1999 |
| Methods and test devices for detecting the presence or amount of target ligand in non-competitive sandwich ligand-receptor assay processes. Antibodies which bind to the complex of ligand receptor and target ligand but do not bind significantly to the ligand receptor and which bind the |
| 5965375 |
Diagnostic tests and kits for Clostridium difficile |
October 12, 1999 |
| This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile detection that involve assaying for both C. difficile glutamate dehydrogenase and C. difficile |
| 5939272 |
Non-competitive threshold ligand-receptor assays |
August 17, 1999 |
| Assay methods for performing non-competitive ligand-receptor assays, where said assays provide a sensible result when the target ligand identified by the assay is present at a concentration greater than a defined threshold concentration. The threshold concentration can be selected to be |
| 5922615 |
Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorb |
July 13, 1999 |
| Devices for use in heterogeneous ligand-receptor assays, having a porous member in contact with a nonabsorbent textured surface, where the surface texturing is such that a capillary network is formed when in fluid communication with the porous member. More particularly, these devices |
| 5914241 |
Assays and kits for detecting analytes in the presence of cross-reacting substances |
June 22, 1999 |
| An immunoassay is provided which is selective for an analyte over immunologically related substances which may be present in a sample to be tested. The presence of the analyte is detected using a first binding substance, typically an antibody, in the presence of a second binding subs |
| 5851776 |
Conjugates and assays for simultaneous detection of multiple ligands |
December 22, 1998 |
| Novel conjugates and competitive and non-competitive assays for simultaneously detecting the presence or amount of at least two target ligands capable of competing with a single conjugate for binding to at least two different ligand receptors. The invention teaches and claims binding |
| 5679526 |
Threshold ligand-receptor assay |
October 21, 1997 |
| This invention is directed to a ligand-receptor assay for determining the presence of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available on a ligand receptor, said ligand analogue conjugate comprising at least one ligand analogue |
| 5525524 |
Crosstalk inhibitors and their uses |
June 11, 1996 |
| Assay for detecting the amount or presence of target ligand in a sample. The assay includes a ligand analogue conjugate having a linkage site and a binding site, a ligand receptor, and a sample. The assay includes the steps of providing at least one crosstalk inhibitor. This inhibitor, u |
| 5480792 |
Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor ass |
January 2, 1996 |
| Methods and test devices for detecting the presence or amount of target ligand in non-competitive sandwich ligand-receptor assay processes. Antibodies which bind to the complex of ligand receptor and target ligand but do not bind significantly to the ligand receptor and which bind the |
| 5143852 |
Antibodies to ligand analogues and their utility in ligand-receptor assays |
September 1, 1992 |
| Means for the detection of free ligand analogue conjugate in fluids from competitive ligand-receptor assay processes. Ligand analogue antibodies that bind the ligand analogue conjugate with substantially greater affinity than their affinity for target ligand are selected and used in |
| 5089391 |
Threshold ligand-receptor assay |
February 18, 1992 |
| This invention is directed to a ligand-receptor assay for determining the presence or amount of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available on a ligand receptor, said ligand analogue conjugate comprising at least one ligan |
| 5028535 |
Threshold ligand-receptor assay |
July 2, 1991 |
| This invention is directed to a ligand-receptor assay for determining the presence or amount of at least one target ligand, capable of competing with a ligand analogue conjugate for binding sites available on a ligand receptor, said ligand analogue conjugate comprising at least one ligan |
| 4727019 |
Method and apparatus for immunoassays |
February 23, 1988 |
| Disclosed herein is an apparatus and process for conducting ligand receptor assays. The apparatus comprises a first member which is a membrane or a filter to which is bound a receptor for the ligand or which is capable of extracting cells carrying the ligand from a fluid sample. The appa |
| 4632901 |
Method and apparatus for immunoassays |
December 30, 1986 |
| Disclosed herein is an apparatus and process for conducting immunoassays. The apparatus comprises a first member which is a membrane or a filter to which is bound an antibody, typically a monoclonal antibody, or which is capable of extracting cells from a fluid sample. The apparatus furt |
