| Patent Number |
Title Of Patent |
Date Issued |
| 7408039 |
Kits for treatment of hematologic disorders |
August 5, 2008 |
| The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, esp |
| 7332157 |
Methods for human allografting |
February 19, 2008 |
| A method of preparing a human recipient for a graft from a human which includes: inducing mixed chimerism in the recipient (e.g., by administering to the recipient irradiation or chemotherapy), administering thymic irradiation, administering an antibody that depletes T cells, adminis |
| 6877514 |
Mixed chimerism and tolerance |
April 12, 2005 |
| A method of inducing tolerance without whole body irradiation. |
| 6718986 |
Mixed chimerism and tolerance |
April 13, 2004 |
| A method of inducing tolerance without whole body irradiation. |
| 6558662 |
Treatment of hematologic disorders |
May 6, 2003 |
| The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, esp |
| 6514513 |
Costimulatory blockade and mixed chimerism in transplantation |
February 4, 2003 |
| Use of blockade of costimulation and hematopoietic stem cell transplantation in the promotion of graft acceptance. |
| 6412492 |
Mixed chimerism and tolerance |
July 2, 2002 |
| A method of inducing tolerance without whole body irradiation. |
| 6296846 |
Induced tolerance to xenografts |
October 2, 2001 |
| The invention features a method designed to lengthen the time an implanted organ (a xenograft) survives in a xenogeneic host prior to rejection. Preparation of the recipient for transplantation includes the following steps: First, the recipient is administered low dose radiation. Second, |
| 6280957 |
Costimulatory blockade and mixed chimerism in allo-transplantation |
August 28, 2001 |
| Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation. |
| 6006752 |
Mixed chimerism and tolerance |
December 28, 1999 |
| A method of inducing tolerance without whole body irradiation. |
| 5756085 |
Use of interleukin-12 to prevent graft versus host disease |
May 26, 1998 |
| The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed. In other embodiments, graft-vs. leukemia effects are maintained or promoted. |
| 5658564 |
Xenograft thymus |
August 19, 1997 |
| The invention features methods of replacing thymus function and inducing immunological tolerance. |
| 5624823 |
DNA encoding procine interleukin-10 |
April 29, 1997 |
| Purified DNA encoding porcine IL-10, porcine IL-10, and methods of inducing immunological tolerance and inhibiting graft versus host disease. |
| 5573764 |
Use of interleukin-12 to prevent graft versus host disease |
November 12, 1996 |
| The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed. |
