| Patent Number |
Title Of Patent |
Date Issued |
| RE39146 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles a |
June 27, 2006 |
| One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the squ |
| 7083778 |
Ultrasound contrast agents and methods of making and using them |
August 1, 2006 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the sur |
| 7033574 |
Stable microbubbles suspensions injectable into living organisms |
April 25, 2006 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obta |
| 6989141 |
Ultrasound contrast agents and methods of making and using them |
January 24, 2006 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obta |
| 6896875 |
Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging |
May 24, 2005 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 6881397 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles a |
April 19, 2005 |
| One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the squ |
| 6726650 |
Automatic liquid injection system and method |
April 27, 2004 |
| A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultr |
| 6613306 |
Ultrasound contrast agents and methods of making and using them |
September 2, 2003 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the sur |
| 6592846 |
Long-lasting aqueous dispersions or suspensions of pressure resistant gas-filled microvesicles a |
July 15, 2003 |
| One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the squ |
| 6585955 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles a |
July 1, 2003 |
| One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the squ |
| 6485705 |
Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging |
November 26, 2002 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 6472488 |
(Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, pol |
October 29, 2002 |
| Polymerizable compositions from novel monomers that correspond to the formula: ##STR1##in which: Z represents H or CH.sub.3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms. |
| 6403057 |
Microcapsules, method of making and their use |
June 11, 2002 |
| The invention relates to microcapsules to a microcapsule with a mean size from a fraction of micrometer to 1000 micrometers having a biodegradable membrane encapsulating a gas core. The membrane comprising one or more biodegradable water insoluble lipids or mixtures thereof and optionall |
| 6333021 |
Microcapsules, method of making and their use |
December 25, 2001 |
| The invention relates to microcapsules to a microcapsule with a mean size from a fraction of micrometer to 1000 micrometers having a biodegradable membrane encapsulating a gas core. The membrane comprising one or more biodegradable water insoluble lipids or mixtures thereof and optionall |
| 6307062 |
(Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, pol |
October 23, 2001 |
| The novel monomers correspond to the formula: ##STR1##in which:Z represents H or CH.sub.3 and X represents O or S, andY is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms. |
| 6258378 |
Delivery of biologically active substance to target sites in the body of patients |
July 10, 2001 |
| The invention concerns a method for administering bioactive substances to patients at selected sites in the body and remotely promoting delivery of said media to selected organs or tissues in the body. The method comprises providing an administrable formulation comprising, dispersed in a |
| 6200548 |
Gas or air filled polymeric microballoons |
March 13, 2001 |
| Microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilsient. These microballoons are used for ultrasonic echographic imaging of body organs. |
| 6187571 |
Use of a DNA sequence coding for a protein capable of degrading oxalic acid as selection gene |
February 13, 2001 |
| The invention relates to the novel use of a sequence coding for a protein capable of degrading oxalic acid to select plant cells which have integrated a gene of interest, and a novel process for selecting, on oxalic acid, cells, calluses or plants transformed by this recombinant DNA. |
| 6187288 |
Stable microbubble suspensions as enhancement agents for ultrasonic echography |
February 13, 2001 |
| Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles agai |
| 6183725 |
Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and metho |
February 6, 2001 |
| The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and |
| 6139818 |
Method of making ultrasonic contrast agent |
October 31, 2000 |
| Methods of making Ultrasonic contrast agents useful for echographic imaging body organs comprising a suspension of gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic poly |
| 6136293 |
Stable microbubbles suspensions containing saturated lamellar phospholipids |
October 24, 2000 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 6123922 |
Resilient deformable microballoons for echographic imaging |
September 26, 2000 |
| Air or gas filled microballoons bounded by an interfacially deposited polymer membrane which can be dispersed in aqueous carrier liquids to be injected into living organisms or administered orally, rectally and urethrally for therapeutic or diagnostic purposes (echography). The propertie |
| 6110443 |
Dry stable formation to produce microbubble suspension for ultrasound |
August 29, 2000 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 6042809 |
Administrable compositions and methods for magnetic resonance imaging |
March 28, 2000 |
| The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast agents involving hyperpolarized |
| 5980937 |
Liposomes with enhanced entrapment capacity and their use in imaging |
November 9, 1999 |
| The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacit |
| 5961956 |
Frozen ultrasonic gas suspensions |
October 5, 1999 |
| Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a |
| 5911972 |
Stable microbubbles suspensions injectable into living organisms |
June 15, 1999 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 5908610 |
Stable microbubble suspensions comprising saturated phospholipios for ultrasonic echography |
June 1, 1999 |
| Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabiliser of the microbubbles agai |
| 5895661 |
Liposome vesicle precursors |
April 20, 1999 |
| The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacit |
| 5863520 |
Method of echographic imaging using polymeric gas or air filled microballoons |
January 26, 1999 |
| Ultrasonic echographic imaging body organs using gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilient are descri |
| 5846518 |
Gas mixtures useful as ultrasound contrast media contrast agents containing the media and method |
December 8, 1998 |
| The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and |
| 5840275 |
Ultrasonic contrast agent with polymeric gas or air filled microballoons |
November 24, 1998 |
| Ultrasonic contrast compositions containing gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient in an aqueous carrier li |
| 5830435 |
Method of storing frozen microbubble suspensions |
November 3, 1998 |
| Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a |
| 5827504 |
Method of echographic imaging using frozen gasbubble suspensions |
October 27, 1998 |
| Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a |
| 5792932 |
Plant promoter, microorganisms and plant cells containing a unit for the expression of a protein |
August 11, 1998 |
| The present invention relates to a plant promoter which comprises the sequence (B) [SEQ ID NO: 4] below: ##STR1## or a sequence having a high degree of homology with the sequence (B). Application: Protection of plants by genetic engineering and especially defense of plants in str |
| 5711933 |
Method of making polymeric gas or air filled microballoons for ultrasonic echography |
January 27, 1998 |
| Method of making gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is deformable and resilient for use in ultrasonic contrast compositions are |
| 5702722 |
Liposomes with enhanced entrapment capacity, method and use |
December 30, 1997 |
| The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacit |
| 5686060 |
Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography |
November 11, 1997 |
| Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles agai |
| 5658551 |
Stable microbubbles suspensions injectable into living organisms |
August 19, 1997 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 5643553 |
Stable microbubbles suspensions injectable into living organisms |
July 1, 1997 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 5626832 |
Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray |
May 6, 1997 |
| Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated |
| 5597549 |
Stable microbubble suspensions as enhancement agents for ultrasound echography |
January 28, 1997 |
| Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles agai |
| 5587199 |
Process of preparing particles for NMR imaging |
December 24, 1996 |
| Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or gl |
| 5578292 |
Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles a |
November 26, 1996 |
| One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the squ |
| 5567414 |
Stable microbubbles suspensions injectable into living organisms |
October 22, 1996 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophillc stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 5556610 |
Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and metho |
September 17, 1996 |
| The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and |
| 5545395 |
Method of imaging using encapsulated magnetite particles |
August 13, 1996 |
| Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or gl |
| 5531980 |
Stable microbubbles suspensions injectable into living organisms |
July 2, 1996 |
| Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained |
| 5464696 |
Particles for NMR imaging |
November 7, 1995 |
| Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or gl |
