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Mariagrazia Pizza Patents |
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Inventor: Pizza; Mariagrazia
Address: Siena, IT
No. of patents: 11
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7427404 |
Pertussis toxin mutants, bordetella strains capable of producing such mutants and their use in t |
September 23, 2008 |
| New pertussis toxin (PT) mutants are described being immunologically active and having reduced or no toxicity, characterized in that at least one of the aminoacid residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly 44, Thr53 and Gly80 or su |
| 7410646 |
Immunologically active polypeptides with altered toxicity useful for the preparation of an antip |
August 12, 2008 |
| Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganism transformed with a hybrid plasmid including the gene/s which codes for at |
| 7291588 |
Immunogenic detoxified mutant E. coli LT-A toxin |
November 6, 2007 |
| An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72 of the A subunits mutated, preferably by substitution with Arg. The toxoid is useful as |
| 7279169 |
Mucosal DTPa vaccines |
October 9, 2007 |
| Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT) or E. coli heat labile toxin (LT). Component (b) acts as a mucosal adjuvant. The acellular |
| 7115730 |
Immunogenic detoxified mutant E. coli LT-A-toxin |
October 3, 2006 |
| An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72, numbered relative to SEQ ID NO:1, of the A subunits mutated, preferably by substitution |
| 6914131 |
Neisserial antigens |
July 5, 2005 |
| The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositio |
| 6713072 |
Immunologically active polypeptides with altered toxicity useful for the preparation of an antip |
March 30, 2004 |
| Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating, a microorganism transformed with a hybrid plasmid including the gene/s which codes for at |
| 6709660 |
Meningococcal antigens |
March 23, 2004 |
| The invention provides proteins from Neisseria meningitidis (strains A & B), including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. |
| 6149919 |
Immunogenic detoxified mutants of cholera toxin and of the toxin LT, their preparation and their |
November 21, 2000 |
| An immunogenic detoxified protein comprising the amino acid sequence of subunit A of cholera toxin (CT-A) or subunit A of an Escherichia coli heat labile toxin (LT-A) or a fragment thereof wherein one or more amino acids at, or in positions corresponding to Val-53, Ser-63, Val-97, Tyr-10 |
| 5925546 |
Immunologically active polypeptides with altered toxicity useful for the preparation of an antip |
July 20, 1999 |
| Immunological active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganism transformed with a hybrid plasmid including the gene/s which codes for at lea |
| 5889172 |
DNA sequences for immunologically active peptides of pertussis toxin |
March 30, 1999 |
| Immunologically active polypeptides with no or reduced toxicity useful for the preparation of an antipertussis vaccine. Method for the preparation of said polypeptides which comprises, cultivating a microorganism transformed with a hybrid plasmid including the gene/s which codes for at l |
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