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Alexander Pasternak Patents |
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Inventor: Pasternak; Alexander
Address: Princeton, NJ
No. of patents: 14
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7410961 |
2,6-disubstituted piperiddines as modulators |
August 12, 2008 |
| The present invention is further directed to compounds of formula (I): wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.16, R.sup.17, R.sup.18, R.sup.19, R.sup.20, R.sup.21 and R.sup.22 are as defined herein) which are modulator |
| 7393844 |
Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
July 1, 2008 |
| The present invention is directed to compounds of the formula (1) Wherein A, B, D, X, Y, n, R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.15, R.sup.16, R.sup.17, R.sup.18 and the dashed line are as defined herein which are useful as modulators of chemokine receptor activity. In particular, t |
| 7390803 |
Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity |
June 24, 2008 |
| The present invention is directed to compounds of the formula (I) (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.27, R.sup.28, R.sup.29, R.sup.30, R.sup.31, X, m, n and the dashed line are defined herein) which are |
| 7247725 |
Gamma-aminoamide modulators of chemokine receptor activity |
July 24, 2007 |
| The present invention is directed to compounds of the formula (I), wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compo |
| 7230008 |
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
June 12, 2007 |
| The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of an inflammatory or immunoregulatory disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I |
| 7166614 |
Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
January 23, 2007 |
| The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the |
| 6812234 |
Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
November 2, 2004 |
| The present invention is directed to compounds of the formula I: ##STR1##(wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In |
| 6545023 |
Cyclopentyl modulators of chemokine receptor activity |
April 8, 2003 |
| The present invention is directed to compounds of the formula I: ##STR1##(wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and X are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the |
| 6387932 |
Somatostatin agonists |
May 14, 2002 |
| This invention relates to non-peptide somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. The compounds provide an improved therapeutic index in the treatment of diabetes, cancer, acromegaly and retenosis. Many of the compounds are ora |
| 6117880 |
Somatostatin agonists |
September 12, 2000 |
| This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. The compounds provide an improved therapeutic index in the treatment of diabetes, cancer, acromegaly and retenosis. Many of the compounds are also orally active. |
| 6063796 |
Somatostatin agonists |
May 16, 2000 |
| This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of the formula: ##STR1## including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the trea |
| 6057338 |
Somatostatin agonists |
May 2, 2000 |
| This invention relates to somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. Compounds of the formula: ##STR1## including pharmaceutically acceptable salts and hydrates thereof are disclosed. These compounds are useful in the trea |
| 6025372 |
Somatostatin agonists |
February 15, 2000 |
| Somatostatin agonist compounds of formula I are disclosed: ##STR1## including pharmaceutically acceptable salts and hydrates thereof These compounds are useful in the treatment of diabetes, cancer, acromegaly, restenosis, depression, irritable bowel syndrome and pain. The compounds |
| 5770732 |
Pyrrolinone-based peptidomimetics |
June 23, 1998 |
| Novel pyrrolinone-based compounds mimic or inhibit the biological and/or chemical activity of peptides, including peptide .beta.-strand conformations. Certain compounds contain functionalized pyrrolinone units in place of one or more amino acids of a target peptide. |
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