| Patent Number |
Title Of Patent |
Date Issued |
| 5583216 |
Methods for the manufacture of cephems |
December 10, 1996 |
| Provided is a process for preparing a cephem compound of the formula: ##STR1## wherein R.sup.3 is hydrogen or methoxy, R.sup.4 is hydrogen or a residue of a nucleophilic compound, R.sup.5 is hydroxyl or a protected hydroxyl, and R.sup.8 is hydrogen or halogen, or a pharmaceutically a |
| 4973684 |
Cephem compounds |
November 27, 1990 |
| Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein R.sup.4 is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl; or a pharmaceutically acceptable salt or ester thereof. |
| 4943666 |
Process for producing nitrophenol compound |
July 24, 1990 |
| An improved industrial process for producing a compound of the general formula: ##STR1## wherein R is an alkyl group having 1 to 4 carbon atoms which comprises reacting a compound of the general formula: ##STR2## wherein R is as defined above with nitrous acid in a mixed solv |
| 4912212 |
Cephem compounds |
March 27, 1990 |
| Broad spectrum antibiotics are provided which are compounds of the formula: ##STR1## wherein -W-R is a residue of a nucleophilic compound and R.sup.5 is hydroxyl or protected hydroxyl, or a pharmaceutically acceptable salt or 4-carboxy ester which is the alkoxymethyl, .alpha.-alkoxye |
| 4842775 |
Reduction of carboxylic esters |
June 27, 1989 |
| A method for producing a compound of the formula: ##STR1## [wherein R.sup.1 and R.sup.2 each stand for a lower alkyl group; n denotes an integer of 0 to 21; X stands for hydrogen atom or an optionally protected hydroxyl group; and Y stands for an optionally protected hydroxyl gro |
| 4668783 |
Thiazolylacetamido cephalosporin compounds |
May 26, 1987 |
| Novel cephem compounds of the formula: ##STR1## wherein R.sup.4 is a residue of a nucleophilic compound selected from hydroxyl, mercapto, cyano, azido, amino, carbamoyloxy, carbamoylthio and thiocarbamoyloxy, said group being unsubstituted or substituted by alkyl of up to three c |
| 4514565 |
Thiazolylacetamido cephalosphorin compounds |
April 30, 1985 |
| 3-Tertiary ammoniomethyl-7-beta-[alpha-(hydroxy or protected hydroxy)imino-alpha-(2-aminothiazol-4-yl)acetamido]-3-cephem-4-carboxylic acid, pharmaceutically acceptable salt or 4-carboxy ester is provided which is a broad spectrum antibiotic. |
| 4355160 |
Thiazolylacetamido cephalosporin type compounds |
October 19, 1982 |
| The present invention is directed to a compound having antibacterial activity of the formula ##STR1## wherein R.sup.1 represents amino, protected amino, hydroxy or protected hydroxy;R.sup.4 represents heterocyclic thio wherein heterocyclic is a 5 to 6 membered hetero ring contain |
| 4298606 |
Thiazolylacetamido compounds |
November 3, 1981 |
| Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into |
| 4205180 |
.alpha.-Alkoxyimino-.beta.-oxo-.gamma.-Bromobutyric acid |
May 27, 1980 |
| Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into |
| 4203899 |
Thiazolylacetamido compounds |
May 20, 1980 |
| Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into |
| 4182868 |
7-Methoxycephalosporin derivatives |
January 8, 1980 |
| A compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or a halogen and R.sup.3 stands for methyl, acetoxymethyl, carbamoyloxymethyl, an alkoxymethyl, an alkylthiomethyl, 2-carboxy-1-ethenyl, or a heterocyclic thiomethyl, or a pharmaceutically acceptable salt thereof, is |
| 4145540 |
7.beta.-Phosphoramido-7.alpha.-methoxycephalosporanic acid derivatives |
March 20, 1979 |
| Cephem and penam compounds having a partial structure of formula (II): ##STR1## wherein R.sup.1 and R.sup.2, respectively, represent a hydrocarbon group which is attached to P, either directly or through an oxygen atom, and which may optionally be substituted, and R.sup.3 is a hydroc |
| 4098888 |
Thiazolylacetamido cephalosporin type compounds |
July 4, 1978 |
| Novel cephem compounds of the formula; ##STR1## wherein R.sup.1 represents amino or hydroxyl group which may be protected, R.sup.2 represents amino or hydroxyl group or a group convertible into these groups, R.sup.3 represents hydrogen or methoxy group or a group convertible into |
| 4008246 |
Aminothiazole derivatives |
February 15, 1977 |
| A compound of the formula: ##STR1## wherein R.sup.1 stands for a halogenoethoxycarbonylamino and R.sup.2 stands for hydrogen or a halogen, is an important intermediate for producing a cephalosporin derivative of the formula: ##STR2## wherein R.sup.3 stands for methyl, acetoxy |
| 4008227 |
Cephalosporins |
February 15, 1977 |
| A compound of the formula: ##STR1## wherein R.sup.1 represents mandeloyl or 2-(3-sydnone)-acetyl group and R.sup.2 represents a hydrogen atom, a halogen, an alkyl or an alkoxyl group, or a pharmaceutically accetable salt thereof, is found to have a broad antimicrobial spectrum an |
