| Patent Number |
Title Of Patent |
Date Issued |
| 4511505 |
Semi-synthesis of human insulin |
April 16, 1985 |
| A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings. |
| 4401757 |
Semi-synthesis of human insulin |
August 30, 1983 |
| A process for preparing B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1. |
| 4400465 |
Semi-synthesis of human insulin |
August 23, 1983 |
| A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings. |
| 4320197 |
Semi-synthesis of human insulin |
March 16, 1982 |
| A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1. |
| 4320196 |
Semi-synthesis of human insulin |
March 16, 1982 |
| A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings. |
