| Patent Number |
Title Of Patent |
Date Issued |
| 7294628 |
Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof |
November 13, 2007 |
| The invention relates to substituted 1-piperazinylacylpiperidine derivatives of general formula (I) ##STR00001## in which: n is 1 or 2; R.sub.1 represents a halogen atom; a trifluoromethyl radical; a (C.sub.1-C.sub.4) alkyl; a (C.sub.1-C.sub.4)alkoxy; a trifluoromethoxy radical; R |
| 7148240 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compo |
December 12, 2006 |
| The invention relates to benzofuran or benzothiophene derivatives of general formula: ##STR00001## These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes of the cardiovascular system. |
| 6949583 |
Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compos |
September 27, 2005 |
| The invention relates to benzofuran or benzothiophene derivatives, to processes for preparing them, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment of pathological syndromes of the cardiovascular system. |
| 6946483 |
Aminoalkenylbenzoyl-benzofuran or benzothiophene, method for preparing same and compositions con |
September 20, 2005 |
| The invention relates to novel (aminoalkenyl-benzoyl) benzofuran or benzothiophene derivatives of general formula: ##STR1##These compounds are of use as medicaments, in particular in the treatment of pathological syndromes of the cardiovascular system. |
| 6627649 |
Pharmaceutical compositions containing in combination two antagonists selective of arginine-vass |
September 30, 2003 |
| The invention relates to pharmaceutical compositions containing (2S)-1-{(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfony l)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl}pyrrolidine-2-carboxamide, a selective V.sub.1a arginine vasopressin receptor antagonist, in combina |
| 6482986 |
Benzene derivatives, preparation method and pharmaceutical compositions containing same |
November 19, 2002 |
| The invention concerns compounds of formula (I) wherein A, X, Y, n, R.sub.1, R.sub.2 and R.sub.3 are as defined in claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system. ##STR1## |
| 6218414 |
Use of an angiotensin II antagonist and a benzofuran derivative in the treatment of cardiovascul |
April 17, 2001 |
| The invention relates to the use of an angiotensin II antagonist and a benzofuran derivative with antiarrhythmic activity in the treatment of cardiovascular complaints, in particular in the treatment of cardiac insufficiency. |
| 5849780 |
1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical com |
December 15, 1998 |
| The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or |
| 5728723 |
1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical comp |
March 17, 1998 |
| The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or |
| 5726322 |
1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compo |
March 10, 1998 |
| The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or |
| 5723611 |
Heteroarylpiperidines |
March 3, 1998 |
| A compound of formula (VIII): ##STR1## in which Alk is a (C.sub.1 -C.sub.4)alkyl group, R.cndot. is hydrogen or a protecting group cleavable by hydrolysis and R is hydrogen, a protecting group cleavable by reduction or a heterocycle of structure (IX): ##STR2## in which Hal is |
| 5686624 |
1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical comp |
November 11, 1997 |
| The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or |
| 5663431 |
1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical comp |
September 2, 1997 |
| The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or |
| 5595994 |
1-Halopyrazin- and 1-halopyrimidin-4-amino-4-alkylpiperidines |
January 21, 1997 |
| The present invention relates to novel heteroarylpiperidines of formula (I): ##STR1## in which Hal is a halogen atom, Alk is a C.sub.1-4 alkyl group and one of X, Y and Z is a nitrogen atom while the others are .dbd.CH--, and their salts. These compounds are useful as 5-HT.sub.3 |
| 5585394 |
1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives |
December 17, 1996 |
| The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: ##STR1## to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin |
| 5578633 |
N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which t |
November 26, 1996 |
| The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors. |
| 5559233 |
Methods for preparing n-substituted heterocyclic derivatives |
September 24, 1996 |
| The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1## |
| 5502063 |
1-halopyridin-4-amino-4-alkylpiperidines |
March 26, 1996 |
| The present invention relates to novel heteroarylpiperidines of formula (I): ##STR1## in which Hal is a halogen atom, Alk is a C.sub.1 -C.sub.4 alkyl group and X, Y and Z are each --CH.dbd. and their salts, to a process for their preparation and to their use as drugs active as 5- |
| 5481005 |
N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which t |
January 2, 1996 |
| The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors. |
| 5397801 |
N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which t |
March 14, 1995 |
| The invention relates to N-sulfonyl derivatives of formulae (I) and (I)' ##STR1## to their preparation, and to pharmaceutical compositions in which they are present. The compounds of formulae (I) and (I)' have an affinity for the vasopressin and ocytocin receptors. |
| 5352788 |
N-substituted heterocyclic derivatives |
October 4, 1994 |
| The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1## wherein the substituents are as described in the specification, and to intermediates. The compounds are useful for antagonizing angiotensin II. |
| 5338755 |
N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which t |
August 16, 1994 |
| The invention relates to N-sulfonyl derivatives of formulae (I)" and (I)' ##STR1## and to pharmaceutical compositions in which they are present. The compounds have an affinity for the vasopressin and ocytocin receptors. |
| 5284838 |
Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
February 8, 1994 |
| The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CH.dbd.CH--E.dbd.CH-- or the group ##STR2## Z represents a halogen or a cyano, acetyl, trifluoroacetyl, nitro, alkylthio, carboxyl, |
| 5270317 |
N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in |
December 14, 1993 |
| The invention relates to N-substituted heterocyclic derivatives and its salts.These derivatives have the formula ##STR1## in which the substituents are as defined in the specification.Application: Angiotensin II antagonists |
| 5225415 |
4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their prepara |
July 6, 1993 |
| The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## |
| 5215988 |
Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same |
June 1, 1993 |
| The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --,R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen,A is selected from a straight- or br |
| 5185345 |
4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them |
February 9, 1993 |
| The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## |
| 5182291 |
Pyrozala-pyridyl aminoabkoxyphenol compounds |
January 26, 1993 |
| Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methy |
| 5134124 |
Use of a statin derivative in the treatment of eye complaints |
July 28, 1992 |
| The invention relates to the use of N-(3-pyridylpropionyl)phenylalanylhistidyl (cyclohexyl)statyl-N-(1,3-dihydroxy-2-methylpropyl)isoleucinamide, which has the formula ##STR1## in which: Phe is the (L)-phenylalanine residue, His is the (L)-histidine residue, Ile is the (L)-is |
| 5116849 |
4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their prepara |
May 26, 1992 |
| The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarrhythmic activities. They respond to formula ##STR1# |
| 5039700 |
Benzofuranyl aminoalkoxyphenyl compounds |
August 13, 1991 |
| Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methy |
| 5017579 |
Use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular press |
May 21, 1991 |
| The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case. |
| 4978759 |
Process for the stereospecific synthesis of optically pure 4-amino-3-hydroxycarboxylic acid deri |
December 18, 1990 |
| The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacted. The resulting pyrrolone de |
| 4957925 |
Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same |
September 18, 1990 |
| An aminoalkoxyphenyl compound of formula ##STR1## as well as a pharmaceutically acceptable salt of this compound. |
| 4943641 |
3-aminoazetidine, its salts, process for their preparation and intermediates of synthesis |
July 24, 1990 |
| The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X" represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' and both X" not being hydrogen at the same time; a process for the p |
| 4840935 |
Peptide amino-alcohol derivatives containing a tetrasubstituted carbon atom, inhibiting renin an |
June 20, 1989 |
| The present invention relates to peptide amino-alcohol derivatives containing a tetra substituted carbon atom. Said peptides inhibit the renin and acid proteases. The invention also relates to the process for their obtention and to pharmaceutical compositions. |
| 4822895 |
3-aminoazetidine, its salts and intermediates of synthesis |
April 18, 1989 |
| The 3-aminoazetidine, its salts, new intermediates of formula ##STR1## wherein X' represents hydrogen or a protecting group and both X" represent hydrogen or, together with the nitrogen atom, a phthalimido group, X' not and both X" being hydrogen at the same time; a process for the p |
| 4814485 |
4-aminobutanoic acid derivatives, process of preparation and use thereof |
March 21, 1989 |
| The invention relates to new (4S)-4-aminobutanoic acid derivatives of general formula: ##STR1## in which: R represents an N-protective group,R.sub.1 represents hydrogen, an alkali metal atom such as lithium, sodium or potassium or a liabile group,R.sub.2 represents a group of formula |
| 4806655 |
Process for the stereospecific synthesis of indole derivatives |
February 21, 1989 |
| The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound |
| 4746648 |
Peptide derivatives which inhibit renin and acid proteases |
May 24, 1988 |
| The invention relates to peptide derivatives modeled on the basis of pepstatin.These derivatives inhibit renin and acid proteases. |
| 4735947 |
Methyllevallorphanium salts having peripheral opiate antagonistic activity |
April 5, 1988 |
| Methyllevallorphanium salts having peripheral antagonistic activity of formula ##STR1## wherein Y.sup.n(-) represents the anion a pharmaceutically acceptable acid other than halogen and n represents the number of negative charges of said anion; a process for their preparation by |
| 4725580 |
Peptide derivatives, analogous to pepstatin, which inhibit renin and acid proteases |
February 16, 1988 |
| The invention relates to pepstatin analogs which inhibit renin and acid proteases.These analogs are particularly suitable for the treatment of arterial tension. |
| 4691019 |
Anorectic agent; 4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine |
September 1, 1987 |
| The invention relates to 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as to |
| 4636490 |
Novel peptidic derivatives inhibiting gastric secretion, process for preparing them and drugs co |
January 13, 1987 |
| The invention relates to peptides of general formula:in which:Asp NH.sub.2 represents the amide in .alpha. position of the aspartic acid of formula: ##STR1## R represents hydrogen, a protector group of the terminal amine function such as t.butyloxy carbonyl (BOC), benzyloxy carbonyl |
| 4602024 |
Substituted trifluoromethylphenyltetrahydropyridines having a cyano substituent and an anorectic |
July 22, 1986 |
| The invention relates to 4-(-3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## in which R represents a cyano, acetyl or cycloalkyl group of from 3 to 7 carbon atoms and Alk represents a straight or branched alkylene of from 1 to 4 carbon atoms, as well as t |
| 4526995 |
3-Amino-n-[2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethyl]benzamide intermediate |
July 2, 1985 |
| Benzamides having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein A represents O, S, N--CN or CH--NO.sub.2 and R represents an alkyl group or an optionally substituted phenyl, pyridyl or pyridyl 1-oxide group; their salts; a process for their preparation; and |
| 4521428 |
Anorexigenic trifluoromethylphenyltetrahydropyridines and pharmaceutical compositions containing |
June 4, 1985 |
| Novel 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines of formula ##STR1## wherein R is an unsubstituted or by an alkyl group of from 1 to 4 carbon atoms substituted pyridyl, pyridyl 1-oxide or naphthyl group and Alk is a straight or branched chain alkylene group of from 2 to |
| 4514408 |
N-substituted nicotinamide 1-oxide as histamine H.sub.2 receptor blockers |
April 30, 1985 |
| N-substituted nicotinamide 1-oxide having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein X is a nitrogen atom or a CH group and Am represents a mono- or disubstituted amino group, a pyrrolidino, morpholino, thiomorpholino, hexamethyleneimino group, or an |
| 4501747 |
Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same |
February 26, 1985 |
| Amides acting as histamine H.sub.2 receptors antagonists, of formula ##STR1## wherein X represents a N.fwdarw.O or C-NH-A-B group in which A is CO or SO.sub.2 and B is alkyl, phenyl, pyridyl, pyridyl 1-oxide, pyrazinyl or thienyl; their salts; process for their preparation by reactin |
| 4492711 |
Benzamides, their salts, and pharmaceutical compositions containing them |
January 8, 1985 |
| Benzamides having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein A represents O, S, N--CN or CH--NO.sub.2 and R represents an alkyl group or an optionally substituted phenyl, pyridyl or pyridyl 1-oxide group; their salts; a process for their preparation; and |
