| Patent Number |
Title Of Patent |
Date Issued |
| 6583118 |
Chondroprotective agents |
June 24, 2003 |
| A chondroprotective agent comprising a flavonoid compound of the general formula (I): ##STR1##wherein R.sup.1 to R.sup.9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a single bond or a double bond, or a stereoisomer thereof, or a naturally occurring |
| 5789432 |
Aromatase-inhibiting composition containing azole derivative |
August 4, 1998 |
| The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): ##STR1## including their stereoisomers and salts thereof, wherein R.sup.1 is halogen or phen |
| 5736522 |
Esculetin derivatives and method for manufacture thereof, use thereof, and pharmaceutical compos |
April 7, 1998 |
| A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, a monosaccharide residue, a protected monosaccharide residue, or a protecting group for hydroxyl group, but at least one of R.sup.1 and R.sup.2 is a monosaccharide residue or |
| 5731293 |
Esculetin derivatives, method for manufacture thereof, and pharmaceutical composition |
March 24, 1998 |
| A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CON(R.sup.4)R.sup.5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R.sup.1 and R.sup.2 is --CON(R.sup.4)R.sup.5, and R.sup.4 and R.sup.5 are, i |
| 5726196 |
Aromatase-inhibiting composition containing azole derivative |
March 10, 1998 |
| The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): ##STR1## including their stereoisomers and salts thereof, wherein R.sup.1 is halogen or phen |
| 5698575 |
Chromone compounds, pharmaceutical compositions containing the same, and use of the same |
December 16, 1997 |
| A chromone derivative of the formula (I): ##STR1## wherein R.sup.11 is a pyrazolyl, pyrrolyl, triazolyl, benzotriazolyl, benzimidazolyl, indazolyl, or indolyl group, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is independently a hydrogen or halogen atom, or a hydroxy or alkoxy group, |
| 5650433 |
Chondroprotective agents |
July 22, 1997 |
| A chondroprotective agent comprising a flavonoid compound of the general formula (I): ##STR1## wherein R.sup.1 to R.sup.9 are, independently, a hydrogen atom, hydroxyl group, or methoxyl group and X is a single bond or a double bond, or a stereoisomer thereof, or a naturally occu |
| 5633393 |
Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for prep |
May 27, 1997 |
| Conjugates of the formula ##STR1## are prepared by reacting an estradiol derivative with a compound of the formula: ##STR2## in the presence of thionyl chloride or a metal hydride at -30.degree. to 150.degree. C. for 3 minutes to 48 hours and then recovering and purifying |
| 5633356 |
3-deoxyglucosone derivatives |
May 27, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5623063 |
3-Deoxyglucosone derivatives and method for determining the same |
April 22, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5621009 |
Chondroprotective agents |
April 15, 1997 |
| A chondroprotective agent comprising a carboxylic acid compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom or an alkyl group of 1 to 6 carbon atoms, or a cis- or trans-isomer thereof, or a pharmaceutically acceptable salt |
| 5618734 |
Method for measuring 3-deoxyglucosone derivatives in a sample |
April 8, 1997 |
| For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as |
| 5571831 |
Imidazole derivative, and pharmaceutical composition |
November 5, 1996 |
| A novel imidazole derivative of the formula (I): ##STR1## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group or a salt thereof, and a pharmaceutical composition containing the same as the active ingredient. |
| 5561125 |
Estradiol derivative and growth inhibiting composition thereof |
October 1, 1996 |
| Estradiol derivatives of the formula: ##STR1## wherein R.sup.1 is C.sub.1-4 alky or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; n is an integer of 1 to 3; and X is hydroxy or halogen are useful as tumor growth inhibiting agents. |
| 5547973 |
Method of inhibiting aromatase |
August 20, 1996 |
| A method of inhibiting aromatase, comprising administering to a mammal in need thereof a pharmaceutical composition comprising an effective aromatase inhibiting amount of a compound of the formula (I): ##STR1## wherein X.sub.1 is a chlorine or fluorine atom, or a hydroxy group, or a |
| 5508298 |
Azole derivative and pharmaceutical composition |
April 16, 1996 |
| A novel azole derivative of the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are, independently from each other, a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, x.sub.1 and x.sub.2 are, independently from each other, a hydrogen or halogen atom, or hydro |
| 5491138 |
Estradiol derivative alkylating agent conjugate with reduced hormonal activity, process for prep |
February 13, 1996 |
| Disclosed is a method of inhibiting the growth of tumors by administering an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer |
| 5489597 |
Azole derivative and pharmaceutical composition |
February 6, 1996 |
| A novel azole derivative of the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are, independently from each other, a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, X.sub.1 and X.sub.2 are, independently from each other, a hydrogen or halogen atom, or hydro |
| 5480878 |
Method for treating prostatic hypertrophy with estradiol derivatives |
January 2, 1996 |
| Disclosed is a method for treating prostatic hypertrophy with an estradiol derivative-alkylating agent conjugate of the formula (1'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3. |
| 5478818 |
Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for prep |
December 26, 1995 |
| Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R.sup.1 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sup.2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3, which is useful a growth inhibiting agent. |
| 5470960 |
Phenylalanine-glycine derivatives, process for preparation thereof, and pharmaceutical compositi |
November 28, 1995 |
| A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described.The novel conjugate of t |
| 5462957 |
Azole derivatives, pharmaceutical compositions containing the same, and method for treating myco |
October 31, 1995 |
| Azole derivatives (including stereoisomers and pharmaceutically acceptable salts) of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each are H or C.sub.1 -C.sub.4 alkyl; R.sub.3 is H, OH, CN, halogen, haloalkyl, C.sub.1 -C.sub.4 alkyl or phenyl, and if there are two or more R. |
| 5455268 |
Esculetin derivatives and pharmaceutical composition |
October 3, 1995 |
| A pharmaceutical composition comprising a compound of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, a hydrogen atom, a saturated or unsaturated aliphatic acyl having 2 to 25 carbon atoms or benzoyl group and R.sup.3 is a hydrogen atom or alkyl |
| 5432190 |
Pharmaceutical compositions containing triazoles and method of treating estrogen-dependent disea |
July 11, 1995 |
| Azole derivatives (including stereoisomers and pharmaceutically acceptable salts) of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each are H or C.sub.1 -C.sub.4 alkyl; R.sub.3 is H, OH, CN, halogen, haloalkyl, C.sub.1 -C.sub.4 alkyl or phenyl, and if there are two or more R. |
| 5411964 |
Phenylalanine-glycine compounds having anti-tumor activity, process for preparation thereof, and |
May 2, 1995 |
| A phenylalanine-glycine compound of formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described. The novel conjugate of the phenyl |
| 5324740 |
Azole derivatives, pharmaceutical compositions containing the same, and method for treating myco |
June 28, 1994 |
| Azole derivatives (including stereoisomers and pharmaceutically acceptable salts) of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each are H or C.sub.1 -C.sub.4 alkyl; R.sub.3 is H, OH, CN, halogen, haloalkyl, C.sub.1 -C.sub.4 alkyl or phenyl, and if there are two or more R. |
| 5286737 |
Method for inhibiting aromatase |
February 15, 1994 |
| This invention provides a method of inhibiting aromatase and treating of estrogen-dependent diseases in a patient by administering azole derivatives as nonsteroidal inhibitors. The azole derivative has the formula ##STR1## where R.sub.1 a is hydrogen or a (C.sub.1 -C.sub.5) alkyl |
| 5116573 |
Labelled vitamin D.sub.3 derivative and production process thereof |
May 26, 1992 |
| The present invention discloses a novel, labelled vitamin D.sub.3 derivative in which hydrogen atoms on the skeleton portion, i.e. 6- and 19-positions, are substituted with a deuterium atom or a tritium atom, as well as a novel production process of the labelled vitamin D.sub.3 deriv |
| 5089481 |
Polysaccharides and antiviral drugs containing the same as active ingredient |
February 18, 1992 |
| Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds. |
| 4985543 |
Lectins and antiretroviral drugs containing the lectins as active ingredient |
January 15, 1991 |
| Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins. |
| 4925662 |
Anti-tumor substance and process for producing the same |
May 15, 1990 |
| Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same. |
| 4758558 |
N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives having antibiotic utility |
July 19, 1988 |
| Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen a |
| 4738843 |
Anti-tumor substance of immunoglobulin and melphalan and process for producing the same |
April 19, 1988 |
| Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same. |
| 4690920 |
Derivative of cephalosporanic acid and pharmaceutical composition comprising the same |
September 1, 1987 |
| Disclosed herein are a derivative of a substituted cephalosporanic acid, represented by the formula (I): ##STR1## wherein p is 0, 1 or 2 and R.sup.1 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.su |
| 4504487 |
Platinum compound and drug |
March 12, 1985 |
| The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug. |
| 4401592 |
Pharmaceutical composition having antitumor activity |
August 30, 1983 |
| Disclosed is a novel pharmaceutical composition having antitumor (anti-cancer) activity without causing pyrexia and anaphylaxis, formed by an amide bonding between an antibody obtained by the purification of the antibody to tumor (cancer) antigen via affinity-chromatography and an an |
| 4372890 |
Platinum compound |
February 8, 1983 |
| The present invention relates to a platinum compound having the formula ##STR1## wherein R represents hydrogen atom, an alkali metal atom or a lower alkyl group. The platinum compound is effective as an antitumor and antimicrobial drug. |
| 4315851 |
Pharmaceutical composition having antitumor activity |
February 16, 1982 |
| Disclosed is a novel pharmaceutical composition having antitumor activity without causing pyrexia and anaphylaxis formed by an amido bonding between an antibody obtained by the purification of the antibody to tumor antigen via affinity-chromatography and an antitumor substance. |
