| Patent Number |
Title Of Patent |
Date Issued |
| 7411061 |
Method of synthesizing polynucleotides using ionic liquids |
August 12, 2008 |
| A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive group may be on a second nucleotide, a polynucleotide, or on a moiety on an insoluble subs |
| 7399844 |
Method and reagents for analyzing the nucleotide sequence of nucleic acids |
July 15, 2008 |
| Methods and reagents are disclosed which provide for more sensitive, more accurate and higher through-put analyses of target nucleic acid sequences. The methods and reagents of the present invention may be generically applied to generally any target nucleic acid sequence and do not r |
| 7371580 |
Use of unstructured nucleic acids in assaying nucleic acid molecules |
May 13, 2008 |
| The present invention provides a system and methods for assaying nucleic acid molecules with reduced levels of background signal and enhanced specificity and sensitivity. In particular, the present invention provides a system and methods for detecting, sorting, tracking and character |
| 7291471 |
Cleavable oligonucleotide arrays |
November 6, 2007 |
| Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described. |
| 7276378 |
Increasing ionization efficiency in mass spectrometry |
October 2, 2007 |
| A system for the analysis of polyionic molecules by mass spectrometry is provided. The polyionic molecule is attached to a charged tag which neutralizes some of the charge on the polyionic analyte. The formed adduct with a reduced net charge is then analyzed by mass spectrometry, and |
| 6858720 |
Method of synthesizing polynucleotides using ionic liquids |
February 22, 2005 |
| A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive group may be on a second nucleotide, a polynucleotide, or on a moiety on an insoluble subs |
| 6852850 |
Use of ionic liquids for fabrication of polynucleotide arrays |
February 8, 2005 |
| A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addr |
| 6743585 |
Methods for preparing conjugates |
June 1, 2004 |
| Methods are disclosed for conjugating one moiety to another moiety. In the method the moieties are reacted with one another in a protic solvent. Reaction between the moieties and the protic solvent during the conjugating is negligible or reversible. A stable bond is formed between th |
| 6716634 |
Increasing ionization efficiency in mass spectrometry |
April 6, 2004 |
| A system for the analysis of polyionic molecules by mass spectrometry is provided. The polyionic molecule is attached to a charged tag which neutralizes some of the charge on the polyionic analyte. The formed adduct with a reduced net charge is then analyzed by mass spectrometry, and the |
| 6706203 |
Adjustable nanopore, nanotome, and nanotweezer |
March 16, 2004 |
| An adjustable nanopore is fabricated by placing the surfaces of two planar substrates in contact, wherein each substrate contains a hole having sharp corners and edges. A corner is brought into proximity with an edge to define a triangular aperture of variable area. Ionic current in a li |
| 6689568 |
Capture arrays using polypeptide capture agents |
February 10, 2004 |
| A method of evaluating for the presence of a polypeptide in an analyte, using an addressable array of capture agents linked to a substrate. The analyte is exposed to the array and a set of fixed capture agents, such that the target molecules will bind to the array by means of the capture |
| 6218118 |
Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spect |
April 17, 2001 |
| Methods and reagents are disclosed which satisfy the need for more sensitive, more accurate and higher through-put analyses of target nucleic acid sequences. The methods and reagents may be generically applied to generally any target nucleic acid sequence and do not require a priori |
| 5608006 |
Entrapped non-enzymatic macromolecules for chemical sensing |
March 4, 1997 |
| A sensor made of porous matrix or sol-gel glass and non-enzymatic macromolecular polymer immobilized in the sol-gel glass. The macromolecule is physically entangled or otherwise trapped, and does not leach regardless of exposure to elevated temperature and pressure. Surface effects a |
| 5580434 |
Interface apparatus for capillary electrophoresis to a matrix-assisted-laser-desorption-ionizati |
December 3, 1996 |
| An apparatus for collecting samples from capillary electrophoresis (CE) for matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) is disclosed. The apparatus has a capillary, a metallic support, a porous member, and a power supply for applying an electrical potential |
| 5527711 |
Method and reagents for binding chemical analytes to a substrate surface, and related analytical |
June 18, 1996 |
| A method is provided for detecting an analyte of interest in a sample. The method involves binding the analyte to the surface of a substrate through a biotin-biotin binding protein interaction, contacting the surface-bound analyte with a quantitatively detectable analyte-binding moiety t |
| 5501836 |
Entrapped non-enzymatic macromolecules for chemical sensing |
March 26, 1996 |
| A sensor made of porous matrix or sol-gel glass and non-enzymatic macromolecular polymer immobilized in the sol-gel glass. The macromolecule is physically entangled or otherwise trapped, and does not leach regardless of exposure to elevated temperature and pressure. Surface effects a |
| 4810456 |
Method of preventing shrinkage defects in electrophoretic gel columns |
March 7, 1989 |
| In forming an electrophoretic gel, various defects can be induced by the shrinkage that generally accompanies polymerization. These defects can include pulling away from a vessel wall or voids or bubbles forming within the gel itself. Prior to polymerization, a monomer can be compressed |
| 4714545 |
Fluid proportioning pump system |
December 22, 1987 |
| A plurality of different liquid solutions are connected to an input of a pump system having at least two displacement chambers and in a manner to control the proportions of each constituent that are taken into each chamber during its intake stroke. The outputs of the chambers are con |
| 4563348 |
Sec-butyl (Z)-7-tetradecenoate and its use as a sex attractant for the grapeleaf skeletonizer |
January 7, 1986 |
| A pheromonal compound produced by the western grapeleaf skeletonizer has been identified as sec-butyl (Z)-7-tetradecenoate. The synthetically-prepared compound demonstrates activity toward both the western grapeleaf skeletonizer, Harrisina brillians Barnes and McDunnough and the grap |
