| Patent Number |
Title Of Patent |
Date Issued |
| 6207671 |
Cycloalkano-pyridines |
March 27, 2001 |
| The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varyin |
| 6127383 |
2-aryl-substituted pyridines |
October 3, 2000 |
| The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of art |
| 6121330 |
5-Hydroxyalkyl substituted phenyls and their use in medicaments for the treatment of arterioscle |
September 19, 2000 |
| The novel 5-hydroxy-alkyl-substituted phenyls are prepared by either reacting the corresponding benzaldehydes with the Grignard compounds and subsequently reducing the other functional groups or by reducing the corresponding benzoic esters by customary methods to give the correspondi |
| 6069148 |
Cycloalkano-pyridines |
May 30, 2000 |
| The cycloalkano-pyridines are prepared by reacting corresponding cycloalkano-pyridine-aldehydes with suitable organometallic compounds or Wittig or Grignard reagents or reacting compounds of the cycloalkano-pyridine alcohols type with suitable bromine compounds, and optionally varyin |
| 5935983 |
Use of phenylcyclohexylcarboxamides |
August 10, 1999 |
| The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis. |
| 5932587 |
Heterocyclic-fused pyridines |
August 3, 1999 |
| The heterocyclic-fused pyridines are prepared by reaction of the corresponding heterocyclic-fused pyridine aldehydes with appropriately substituted Grignard or Wittig reagents. The heterocyclic-fused pyridines are suitable as active compounds in medicaments, in particular in medicame |
| 5925645 |
2-aryl-substituted pyridines |
July 20, 1999 |
| The 2-aryl-substituted pyridines are prepared by reacting pyridylaldehydes with organometallic compounds and then selectively reducing the products. The 2-aryl-substituted pyridines are suitable as active compounds in medicaments, in particular in medicaments for the treatment of art |
| 5863930 |
Trisubstituted biphenyls |
January 26, 1999 |
| Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments. |
| 5834481 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
November 10, 1998 |
| Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicame |
| 5776964 |
Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments |
July 7, 1998 |
| The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be |
| 5712296 |
Substituted pyridines and 2-oxo-1,2-dihydropyridines |
January 27, 1998 |
| Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medic |
| 5708003 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
January 13, 1998 |
| Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicam |
| 5693650 |
4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives |
December 2, 1997 |
| 4-(Quinolin-2-yl-methoxy)-phenyl-acetic acid derivatives are prepared by reacting quinoline-methoxy-phenyl-acetic acids with the corresponding glycinol derivatives, if appropriate with activation of the carboxylic acid function. The new compounds are suitable as active compounds in m |
| 5627285 |
Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives |
May 6, 1997 |
| Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in |
| 5607962 |
Substituted indole derivatives |
March 4, 1997 |
| Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular in medicaments for the treat |
| 5599823 |
Substituted biphenylpyridones |
February 4, 1997 |
| Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. |
| 5596006 |
Trisubstituted biphenyls |
January 21, 1997 |
| Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,R.sub.2 represents straight-chain or branched C.sub.1 -C.sub.8 -alkyl,R.sub.3 represents h |
| 5594010 |
Substituted monopyridylmethyl derivatives |
January 14, 1997 |
| The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis. |
| 5576342 |
Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives |
November 19, 1996 |
| Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments. |
| 5530016 |
Substituted 2,4-imidazolidinediones |
June 25, 1996 |
| Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid deri |
| 5527809 |
Substituted imidazo[4,5-b]pyridines and benzimidazoles |
June 18, 1996 |
| Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in pa |
| 5521206 |
Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments |
May 28, 1996 |
| The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitro |
| 5508299 |
Imidazolyl-substituted cyclohexane derivatives |
April 16, 1996 |
| Imidazolyl-substituted cyclohexane derivatives are prepared by reacting appropriate cyclohexane derivatives with substituted imidazoles and subsequent variation of the substituents.The imidazolyl-substituted cyclohexane derivatives can be employed as active compounds in medicaments, in p |
| 5492923 |
Substituted pyridines and 2-oxo-1,2-dihydropyridines |
February 20, 1996 |
| Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medic |
| 5478836 |
Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
December 26, 1995 |
| Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicam |
| 5475016 |
Sulphonylbenzyl-substituted imidazolypropenoic acid derivatives |
December 12, 1995 |
| Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in |
| 5459156 |
Imidazolyl-substituted phenylacetic acid prolinamides |
October 17, 1995 |
| Imidazolyl-substituted phenylacetic acid prolinamides are prepared by reacting corresponding imidazolyl-substituted phenylacetic acids with prolines. The imidazolyl-substituted phenylacetic acid prolinamides can be used as active compounds in medicaments, preferably for the treatment of |
| 5420149 |
Imidazolyl-substituted phenylacetamides |
May 30, 1995 |
| Imidazolyl-substituted phenylacetic acid derivatives are prepared by first reacting suitably substituted phenylacetic acid with imidazoles and subsequently converting the product into an amide. The compounds can be employed as active compounds in medicaments, in particular for treating |
| 5414008 |
Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives |
May 9, 1995 |
| Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The imidazolyl-substituted phenylpropionic and cinnamic acid derivatives can be used as active compounds |
| 5414003 |
Pyridinylmethyl-substituted pyridines and pyridones |
May 9, 1995 |
| Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatme |
| 5407948 |
Substituted mono- and bipyridylmethylpyridones |
April 18, 1995 |
| Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones c |
| 5407942 |
Biphenylmethyl-substituted pyridones |
April 18, 1995 |
| Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds.The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis. |
| 5395840 |
Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives |
March 7, 1995 |
| Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides.The compounds can be employed as active compounds in medicaments for the treatment of arterial hypertension and atheroscle |
| 5376671 |
Propenoyl-imidazole derivatives |
December 27, 1994 |
| Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypert |
| 5364942 |
Sulphonylbenzyl-substituted imidazopyridines |
November 15, 1994 |
| Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment o |
| 5356911 |
Substituted biphenylpyridones |
October 18, 1994 |
| Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. |
| 5354749 |
Sulfonylbenzyl-substituted benzo- and pyridopyridones |
October 11, 1994 |
| Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the |
| 5352687 |
Substituted phenylacetamides |
October 4, 1994 |
| Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis. |
| 5318980 |
Sulphonylbenzyl-substituted imidazoles |
June 7, 1994 |
| Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicamen |
| 5294633 |
Imidazolyl-propenoic acid derivatives |
March 15, 1994 |
| Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments. |
| 5254543 |
Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists |
October 19, 1993 |
| Sulphonylbenzyl-substituted pyridones can be prepared by reacting pyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis. |
| 5225428 |
Cyclic-substituted imidazolyl-propenoic acid derivatives |
July 6, 1993 |
| Cyclic-substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes and subsequent elimination of water. The cyclic-substituted imidazolylpropenoic acid derivates are suitable as active substances in medicaments, in particular for the treatment of high b |
