| Patent Number |
Title Of Patent |
Date Issued |
| 7268140 |
Piperazine derivatives and their use as anti-inflammatory agents |
September 11, 2007 |
| This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in huma |
| 7176207 |
Platelet adenosine diphosphate receptor antagonists |
February 13, 2007 |
| Compounds of the following formula (I): ##STR00001## where A, a, b, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds |
| 7026323 |
Platelet adenosine diphosphate receptor antagonists |
April 11, 2006 |
| Compounds of the following formula (I): ##STR00001## where a, b, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds |
| 6995156 |
Platelet adenosine diphosphate receptor antagonists |
February 7, 2006 |
| Compounds of the following formula (I): ##STR00001## where a, b, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds |
| 6977258 |
Piperazine derivatives and their use as anti-inflammatory agents |
December 20, 2005 |
| This invention is directed to acyl piperazine derivatives of formula (Ia): ##STR1##wherein R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, |
| 6972290 |
Piperazine derivatives and their use as anti-inflammatory agents |
December 6, 2005 |
| This invention is directed to acyl piperazine derivatives which are useful as anti-inflammatory agents. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans. |
| 6887865 |
N-heterocyclic derivatives as NOS inhibitors |
May 3, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6864368 |
N-heterocyclic derivatives as NOS inhibitors |
March 8, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6864263 |
N-heterocyclic derivatives as NOS inhibitors |
March 8, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6861424 |
Platelet adenosine diphosphate receptor antagonists |
March 1, 2005 |
| Compounds of the following formula (I): ##STR1##where a, b, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.6 are described herein, are useful as inhibitors of platelet adenosine diphosphate. Pharmaceutical compositions containing these compounds, methods of using these compounds as ant |
| 6849739 |
N-heterocyclic derivatives as NOS inhibitors |
February 1, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6846829 |
N-heterocyclic derivatives as NOS inhibitors |
January 25, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6841674 |
N-heterocyclic derivatives as NOS inhibitors |
January 11, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6841673 |
N-heterocyclic derivatives as nos inhibitors |
January 11, 2005 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6747031 |
N-heterocyclic derivatives as NOS inhibitors |
June 8, 2004 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6686364 |
Benzamidine derivatives and their use as anti-coagulants |
February 3, 2004 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6670473 |
N-heterocyclic derivatives as NOS inhibitors |
December 30, 2003 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6573266 |
Piperazine derivatives and their use as anti-inflammatory agents |
June 3, 2003 |
| This invention is directed to acyl piperazine derivatives of the following formula (Id): ##STR1##wherein R.sup.1b, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.10 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also directed to pharma |
| 6555537 |
Piperazine derivatives and their use as anti-inflammatory agents |
April 29, 2003 |
| This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): ##STR1##wherein R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are described herein. These derivatives are useful as anti-inflammatory agents. This invention is also dire |
| 6541476 |
Piperazine derivatives and their use as anti-inflammatory agents |
April 1, 2003 |
| This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): ##STR1##wherein R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are described herein. These derivatives are useful anti-inflammatory agents. This invention is also directe |
| 6534509 |
Piperazine derivatives and their use as anti-inflammatory agents |
March 18, 2003 |
| This invention is directed to acyl piperazine derivatives, for example, of the following formula (1a): ##STR1##wherein R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are descried herein. These derivatives are useful as anti-inflammatory agents. This invention is also direc |
| 6498185 |
Ortho-anthranilamide derivatives as anti-coagulants |
December 24, 2002 |
| This invention is directed to compounds of formula (III): ##STR1##wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti coagulants. |
| 6479485 |
Benzamidine derivatives and their use as anti-coagulants |
November 12, 2002 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6465459 |
Benzamidine derivatives and their use as anti-coagulants |
October 15, 2002 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6432947 |
N-heterocyclic derivatives as NOS inhibitors |
August 13, 2002 |
| N-Heterocyclic derivatives of the formula (I): ##STR1##are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and pr |
| 6380221 |
Ortho-anthranilamide derivatives as anti-coagulants |
April 30, 2002 |
| This invention is directed to compounds of formula (III): ##STR1##wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These components are disclosed as being useful as anti-coagulants. |
| 6350746 |
Benzamidine derivatives and their use as anti-coagulants |
February 26, 2002 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6306884 |
Benzamidine derivatives and their use as anti-coagulants |
October 23, 2001 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6274091 |
Apparatus and process for multiple chemical reactions |
August 14, 2001 |
| Multiple chemical reactions are performed in a plurality of reaction vessels mounted in inlets in a manifold valve block. The manifold valve block is connected to a channel block which is utilized in conjunction with a solvent delivery system as part of the reaction cycle. The solvent |
| 6265404 |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and |
July 24, 2001 |
| This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of usi |
| 6242454 |
Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as |
June 5, 2001 |
| This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds t |
| 6232325 |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatves and |
May 15, 2001 |
| This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of usi |
| 6221886 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants |
April 24, 2001 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6207665 |
Piperazine derivatives and their use as anti-inflammatory agents |
March 27, 2001 |
| This invention is directed to acyl piperazine derivatives of formula (Ia): ##STR1##wherein R.sup.1a, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, |
| 6177473 |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and |
January 23, 2001 |
| This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of usi |
| 6166088 |
Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as |
December 26, 2000 |
| This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds t |
| 6166014 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants |
December 26, 2000 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6162807 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants |
December 19, 2000 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6150382 |
Thio acid derived monocyclic n-heterocyclics as anticoagulants |
November 21, 2000 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6140351 |
Ortho-anthranilamide derivatives as anti-coagulants |
October 31, 2000 |
| This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants. |
| 6071912 |
Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as |
June 6, 2000 |
| This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds t |
| 6034103 |
Benzamidine derivatives and their use as anti-coagulants |
March 7, 2000 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 6034084 |
Thio acid derived monocyclic N-heterocyclics as anticoagulants |
March 7, 2000 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6008234 |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and |
December 28, 1999 |
| This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of usi |
| 6004985 |
Thio acid derived monocylic N-heterocyclics as anticoagulants |
December 21, 1999 |
| This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the |
| 6004981 |
Benzamidine derivatives and their use as anti-coagulants |
December 21, 1999 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 5994375 |
Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as |
November 30, 1999 |
| This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds t |
| 5889005 |
Benzamidine derivatives and their use for treating thrombotic diseases |
March 30, 1999 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
| 5888830 |
Apparatus and process for multiple chemical reactions |
March 30, 1999 |
| Multiple chemical reactions are performed in a plurality of reaction vessels mounted in inlets in a manifold valve block. The manifold valve block is connected to a channel block which is utilized in conjunction with a solvent delivery system as part of the reaction cycle. The solvent |
| 5883100 |
Benzamidine derivatives and their use as anti-coagulants |
March 16, 1999 |
| This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic |
