| Patent Number |
Title Of Patent |
Date Issued |
| 6541463 |
Inhibitors of type 5 and type 3 17.beta.-hydroxysteroid dehydrogenase and methods for their use |
April 1, 2003 |
| Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17.beta.-hydroxysteroid dehydrogenase. Novel inhibitors of type 5 |
| 6110906 |
Androgen derivatives for use in the inhibition of sex steroid activity |
August 29, 2000 |
| Methods for treating sex steroid-dependent diseases by inhibiting sex steroid activity include administration of novel compounds which include an androgenic nucleus substituted at a ring carbon with at least one substituent specified herein. Such compounds may function by inhibiting |
| 6060503 |
Benzopyran-containing compounds and method for their use |
May 9, 2000 |
| Certain benzopyran antiestrogens are disclosed for treating estrogen sensitive diseases such as breast cancer. Prodrug forms provide ease of manufacturing, good shelf life, and bioavailability, and preferred stereoisomers are shown to be more effective than racemic mixtures. |
| 6015806 |
Antiandrogens |
January 18, 2000 |
| Androgen nucleus derivatives having specified substituents at the 17.alpha. position are disclosed for use as antiandrogens for the treatment of androgen-dependent diseases. In some preferred embodiments, the compound ##STR1## is formulated together with pharmaceutically acceptable d |
| 5879711 |
Stable antiandrogenic gel composition |
March 9, 1999 |
| Pharmaceutical compositions for the topical treatment of androgen-related conditions, e.g., acne in humans containing an amount of the compound represented by formula II effective for the topical treatment of the androgen-related conditions, e.g., acne ##STR1## dissolved in an al |
| 5840735 |
Sex steroid activity inhibitors |
November 24, 1998 |
| Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment o |
| 5686465 |
Sex steroid activity inhibitors |
November 11, 1997 |
| Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment o |
| 5686437 |
Estrogen nucleus derivatives for use in the inhibition of sex steroid activity |
November 11, 1997 |
| Novel derivatives of estrogenic nuclei, contain a side-chain substitution of the formula --R.sup.1 [B--R.sup.2 --].sub.x L--G and may be used in pharmaceutical compositions as sex steroid activity inhibitors useful in the treatment of both androgen-related and estrogen-related diseases. |
| 5631249 |
Estrogen nucleus derivatives for use in the inhibition of sex steroid activity |
May 20, 1997 |
| Novel compounds for the inhibition of sex steroid activity for the treatment of both androgen-related and estrogen-related diseases include for example 15- and 16-halo substituted compounds such as: ##STR1## The compounds are characterized by an estrogenic nucleus substituted with |
| 5585405 |
Inhibitors of sex steroid biosynthesis and methods for their production and use |
December 17, 1996 |
| Certain steroidal and non-steroidal compounds have been found to inhibit androgen and estrogen formation. Such inhibition may aid in the reduction of the activity of these hormones and may be useful in the treatment of diseases where, for example, inhibition of androgen or estrogen activ |
| 5395842 |
Anti-estrogenic compounds and compositions |
March 7, 1995 |
| Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical compositions are useful for the treatment o |
| 5393785 |
Therapeutic antiestrogens |
February 28, 1995 |
| Novel antiestrogenic compounds are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified diphenylethane and diphenylethylene analogs which show strong affinity for estrogen receptors but substantially lack the capacity |
| 5364847 |
Inhibitors of sex steroid biosynthesis and methods for their production and use |
November 15, 1994 |
| Certain steroidal and non-steroidal compounds have been found to inhibit androgen and estrogen formation. Such inhibition may aid in the reduction of the activity of these hormones and may be useful in the treatment of diseases where, for example, inhibition of androgen or estrogen aciti |
| 5227375 |
Aromatase inhibitors |
July 13, 1993 |
| Novel aromatase inhibitors are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified 7.alpha.-substituted androstanedione and androstenedione derivatives which show a strong inhibitory activity towards aromatase. The i |
| 5204337 |
Estrogen nucleus derivatives for use in inhibition of sex steroid activity |
April 20, 1993 |
| Novel compounds for the inhibition of sex steroid activity for the treatment of both androgen-related and estrogen-related diseases include for example 15- and 16-halo substituted compounds such as: ##STR1## The compounds are characterized by an estrogenic nucleus substituted with |
