| Patent Number |
Title Of Patent |
Date Issued |
| 7247734 |
3,4-diarylpyrazoles and their use in the therapy of cancer |
July 24, 2007 |
| The present invention pertains to the use of certain 3,4-diarylpyazoles of formula (I), both in vitro and in vivo, to inhibit heat shock protein 90 (HSP90), and in the treatment of conditions mediated by HSP90, including, for example, cancer; wherein: Ar.sup.3 is independently: a C.sub.5 |
| 7179819 |
VLA-4 inhibitor compounds |
February 20, 2007 |
| Compounds that selectively inhibit the binding of ligands to .alpha.4.beta.1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: ##STR00001## As selective inhibitors of VLA-4 mediated cell adhe |
| 7084154 |
2-(aminomethyl) arylamide analgesics |
August 1, 2006 |
| A chemical genus of 2-(aminomethyl)arylamides, which are useful as analgesics, is disclosed. The genus is represented by the formula I: ##STR00001## A representative example is: ##STR00002## |
| 6906067 |
N-heterocyclic inhibitors of TNF-.alpha. expression |
June 14, 2005 |
| N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: ##STR1##Methods of production, pharmaceutical compositions and methods of treating conditions associ |
| 6900213 |
Bisaryl derivatives having FSH modulatory activity |
May 31, 2005 |
| The invention relates to bisaryl derivatives of the formula I, ##STR1##wherein (R,R) is selected from (H,H), O, (H,CH.sub.3), (H,OH) and (H,CN); Ar is substituted phenyland A is a group of formula II, III, IV or V: ##STR2##An example is (3S,6S)-1-N-(7-phenylheptyl)-3-(4-(3,4,5-trimet |
| 6756378 |
VLA-4 inhibitor compounds |
June 29, 2004 |
| Compounds that selectively inhibit the binding of ligands to .alpha.4.beta.1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: ##STR1##As selective inhibitors of VLA-4 mediated cell adhesion, |
| 6093799 |
Universal linker for combinatorial synthesis |
July 25, 2000 |
| A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH |
| 6008321 |
Universal linker for combinatorial synthesis |
December 28, 1999 |
| A substrate for solid phase synthesis of the formula: ##STR1## is disclosed. Also disclosed are processes for preparing the substrate and intermediates useful therein. Among the novel intermediates are compounds of the formula: ##STR2## wherein t is 0 or 1; n is 3-20; R is OH |
| 5011359 |
Silo rotary unloader monitor |
April 30, 1991 |
| A silo rotary unloader monitor provides an indication of a rotational speed of the rotary collector ring of a material unloading device suspended within the top portion of a vertical silo. A limit switch has an actuating sensor biased into engagement with a sinusoidal cylindrical surface |
| 5010200 |
Pyrimidine derivatives |
April 23, 1991 |
| This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 is selected from alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; and cycloalkyl optionally substituted by alkyl or halo |
| 4962109 |
Insecticidally and acaricidally active pyrimidine esters and intermediates therefor |
October 9, 1990 |
| This invention provides novel insecticidally and acaricidally active pyrimidine derivatives of formula (I): ##STR1## and stereoisomers thereof, wherein R.sup.1 is selected from alkyl; alkenyl; alkynyl; haloalkyl; haloalkenyl; and cycloalkyl optionally substituted by alkyl or halo |
| 4898968 |
Cyclopropane derivatives |
February 6, 1990 |
| Compounds of the formula ##STR1## wherein R.sup.2 represents an .alpha.-branched alkyl group containing from 3 to 6 carbon atoms, and R represents either (a) hydroxy, halo or alkoxy of up to six carbon atoms, or (b) the group --OR.sup.1 where R.sup.1 is the residue of an alcohol |
| 4762835 |
Pyrimidine derivatives |
August 9, 1988 |
| A compound of formula: ##STR1## wherein R.sup.1 represents hydrogen or halogen, R.sup.2 represents an .alpha.-branched alkyl or a cycloalkyl group containing from 3 to 6 carbon atoms, Q represents hydroxy, halo, alkoxy of up to 6 carbon atoms or a group --OR where R represents th |
| 4760143 |
Cyclopropane derivatives |
July 26, 1988 |
| Cyclopropane acids and derivatives thereof useful as intermediates, insecticidally active esters of these acids, compositions comprising these esters and methods of using the same. The compounds involved have the formula: ##STR1## wherein R.sup.2 represents an .alpha.-branched al |
| 4661488 |
Pyrimidine substituted-2,2-dimethylcyclopropane carboxylates useful for combating insect and aca |
April 28, 1987 |
| A compound of formula: ##STR1## wherein R.sup.2 represents an .alpha.-branched alkyl group containing from 3 to 6 carbon atoms, and R represents either (a) hydroxy, halo or alkoxy of up to six carbon atoms, or (b) the group --OR.sup.1 where R.sup.1 is the residue of an alcohol of |
