| Patent Number |
Title Of Patent |
Date Issued |
| 7341718 |
Neuronal gene transfer of adenovirus and herpes virus vectors |
March 11, 2008 |
| The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of compounds that cause synaptic nerve sprouting to increase neuron retrograde transport of a |
| 7273854 |
Pharmaceutical compositions and utilization thereof particularly for the treatment of neurodegen |
September 25, 2007 |
| The present invention relates to pharmaceutical compositions that act on the p53 protein or its gene and methods of use for the treatment of neurodegenerative diseases. |
| 7241591 |
Adenovirus comprising a gene coding for glutathione peroxidase |
July 10, 2007 |
| The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical compositions. |
| 7018628 |
Vectors derived from baculovirus and use for transferring nucleic acids into nerve cells of vert |
March 28, 2006 |
| The invention concerns novel recombinant viruses and their use for gene-transfer into nerve cells of vertebrates. The invention also concerns pharmaceutical compositions comprising said recombinant viruses. More particularly, the invention concerns novel vectors derived from baculovi |
| 6998474 |
Polypeptides of the "basic helix-loop-helix" bHLH family, corresponding nucleic acid sequences |
February 14, 2006 |
| The present invention relates to nucleic acids that encode novel basic helix-loop-helix polypeptides. The present invention also relates to novel basic helix-loop-helix polypeptides, in particular, rat Relax and human ngn3 polypeptides. The invention also relates to methods for the d |
| 6943016 |
Human adult astrocytes, their preparation and uses thereof |
September 13, 2005 |
| The invention provides an essentially pure preparation of human adult astrocytes, and a method of producing same. The purified astrocytes are useful for the treatment of neurodegenerative disorders or trauma to the central nervous system. |
| 6756523 |
Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system pa |
June 29, 2004 |
| The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, incl |
| 6723315 |
Method for treating amyotrophic lateral sclerosis |
April 20, 2004 |
| The invention concerns a novel method for treating motor neuron diseases and particularly amyotrophic lateral sclerosis. It consists more particularly in the systemic administration of expression systems of neurotrophic factors. |
| 6685934 |
Recombinant adenoviruses coding for basic fibroblast growth factors (BFGF) |
February 3, 2004 |
| Recombinant adenoviruses comprising a heterologous DNA sequence coding for basic blast growth factors (bFGF), preparation and uses thereof for the treatment and/or prevention of neurodegenerative diseases. |
| 6632427 |
Adenoviral-vector-mediated gene transfer into medullary motor neurons |
October 14, 2003 |
| The present invention relates to methods and compositions for delivering a nucleic acid to motor neurons administering the nucleic acid to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases. |
| 6552003 |
Muscle reinnervation and motor axon sprouting by administering DNA sequences encoding NT-3 and C |
April 22, 2003 |
| The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases. |
| 6458529 |
Assays for promoter operability in central nervous system cells |
October 1, 2002 |
| The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, incl |
| 6432701 |
Derived tyrosine hydroxylase gene expression system |
August 13, 2002 |
| The invention discloses a new system for gene expression. The system is based in particular on the use of derived sequences of the first intron of the tyrosine hydroxylase gene having transcription enhancing properties. The system is particularly useful in the production of proteins in v |
| 6245330 |
Recombinant adenoviruses coding for glial-derived neurotrophic factor (GDNF) |
June 12, 2001 |
| Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic growth factor (GDNF) are provided. The recombinant adenoviruses are useful in a method of expressing GDNF in a cell, wherein the cell is present in a mammal suffering from Parkinson's |
| 6235497 |
Recombinant expression of the rat vesicular acetylcholine transporter |
May 22, 2001 |
| A nucleic sequence coding for a protein involved in the vesicular transport of acetylcholine, the corresponding protein and the promoter sequences implicated in expressing said protein are disclosed. The invention also discloses expression vectors containing said sequence and the therape |
| 6210879 |
Method for diagnosing schizophrenia |
April 3, 2001 |
| The present invention relates to a method for diagnosing schizophrenia, said method being based on the detection in vitro of the presence of the allele Ep of the microsatellite HUNTH01 in the gene TH. The invention also relates to the primers used for implementing said method. |
| 6140112 |
Pharmaceutical compositions and their use, namely for the treatment of neurodegenerative disease |
October 31, 2000 |
| The present invention pertains to the use of compounds affecting the activity of transcription factors for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases. |
| 5648259 |
Polypeptides having NMDA receptor activity, nucleic acids encoding those polypeptides and applic |
July 15, 1997 |
| The present invention concerns novel polypeptides having NMDA receptor activity and genetic material permitting their expression. It also concerns a method for demonstrating and isolating ligands and/or modulators of the activity of these polypeptides and their utilization as drugs. |
