| Patent Number |
Title Of Patent |
Date Issued |
| 7429455 |
Methods for genotyping hepatitis C virus |
September 30, 2008 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 7407782 |
Nucleic acid detection compositions |
August 5, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7381530 |
Kits for detection of nucleic acids by invasive cleavage |
June 3, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7354708 |
Invasion assays |
April 8, 2008 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 7273696 |
Kits for the detection of target sequences |
September 25, 2007 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the de |
| 7122364 |
FEN endonucleases |
October 17, 2006 |
| The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In |
| 7101672 |
Target-dependent reactions using structure-bridging oligonucleotides |
September 5, 2006 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the |
| 7087381 |
Detection of target sequences by cleavage of non-target nucleic acids |
August 8, 2006 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, we used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the det |
| 7067643 |
Systems for the detection of target sequences |
June 27, 2006 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the de |
| 7011944 |
Invasive cleavage of nucleic acids |
March 14, 2006 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6875572 |
Nucleic acid detection assays |
April 5, 2005 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6872816 |
Nucleic acid detection kits |
March 29, 2005 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6780585 |
Polymorphism analysis by nucleic and acid structure probing |
August 24, 2004 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6759226 |
Enzymes for the detection of specific nucleic acid sequences |
July 6, 2004 |
| The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that |
| 6709819 |
Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
March 23, 2004 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6709815 |
Target-dependent reactions using structure-bridging oligonucleotides |
March 23, 2004 |
| The present invention relates to methods and compns. for treating nucleic acids, and in particular, methods and compns. for the detection and characterization of nucleic acid sequences and sequence changes. The invention provides methods for examg. the conformations assumed by single |
| 6673616 |
Methods and compositions for characterizing nucleic acids |
January 6, 2004 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detect |
| 6635463 |
Enzymes for the detection of nucleic acid sequences |
October 21, 2003 |
| The present invention relates to novel enzymes designed for direct detection, characterization and quantitation of nucleic acids, particularly RNA. The present invention provides enzymes that recognize specific nucleic acid cleavage structures formed on a target RNA sequence and that |
| 6562611 |
FEN-1 endonucleases, mixtures and cleavage methods |
May 13, 2003 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. St |
| 6555357 |
FEN-1 endonuclease, mixtures and cleavage methods |
April 29, 2003 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. St |
| 6458535 |
Detection of nucleic acids by multiple sequential invasive cleavages 02 |
October 1, 2002 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6372424 |
Rapid detection and identification of pathogens |
April 16, 2002 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detect |
| 6348314 |
Invasive cleavage of nucleic acids |
February 19, 2002 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 6214545 |
Polymorphism analysis by nucleic acid structure probing |
April 10, 2001 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6210880 |
Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides |
April 3, 2001 |
| The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention pe |
| 6090606 |
Cleavage agents |
July 18, 2000 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic acid sequences. St |
| 6090543 |
Cleavage of nucleic acids |
July 18, 2000 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucl |
| 5994069 |
Detection of nucleic acids by multiple sequential invasive cleavages |
November 30, 1999 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 5985557 |
Invasive cleavage of nucleic acids |
November 16, 1999 |
| The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the |
| 5888780 |
Rapid detection and identification of nucleic acid variants |
March 30, 1999 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5' nucleases and 3' exonucleases, are used to screen for known and unknown mutations, including single base changes, in nucleic acids. Methods are provided |
| 5871911 |
Method of site-specific nucleic acid cleavage |
February 16, 1999 |
| A method of cleaving a target nucleic acid molecule is disclosed. A cleavage structure is formed that comprises the target nucleic acid and a pilot nucleic acid. A first region of the target nucleic acid is annealed to the pilot nucleic acid to form a duplex structure. A second region of |
| 5843669 |
Cleavage of nucleic acid acid using thermostable methoanococcus jannaschii FEN-1 endonucleases |
December 1, 1998 |
| The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Structure-specific nucleases, including 5' nucleases, thermostable FEN-1 endonucleases and 3' exonucleases, are used to detect and identify target nucleic acids. Methods a |
| 5837450 |
Detection of target nucleic acid molecules using thermostable 5' nuclease |
November 17, 1998 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
| 5795763 |
Synthesis-deficient thermostable DNA polymerase |
August 18, 1998 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
| 5719028 |
Cleavase fragment length polymorphism |
February 17, 1998 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
| 5691142 |
Detection of target nucleic acid molecules using synthesis-deficient thermostable DNA polymerase |
November 25, 1997 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. In t |
| 5614402 |
5' nucleases derived from thermostable DNA polymerase |
March 25, 1997 |
| A means cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. |
| 5541311 |
Nucleic acid encoding synthesis-deficient thermostable DNA polymerase |
July 30, 1996 |
| A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences. Clea |
| 5422253 |
Method of site specific nucleic acid cleavage |
June 6, 1995 |
| A method of cleaving a target nucleic acid molecule is disclosed. A cleavage structure is formed that comprises the target nucleic acid and a pilot nucleic acid. A first region of the target nucleic acid is annealed to the pilot nucleic acid to form a duplex structure. A second region of |
