| Patent Number |
Title Of Patent |
Date Issued |
| RE34069 |
Process for the preparation of oligonucleotides |
September 15, 1992 |
| The invention relates to a process for the preparation of oligonucleotides by the following steps: reaction of a nucleoside with a phosphine derivative, reaction of the nucleotide derivative thus obtained with a nucleoside bonded to a polymeric carrier, oxidation of the carrier-bound |
| 7390672 |
Matrix-assisted laser desorption ionization mass spectrometry substrates having low volume matri |
June 24, 2008 |
| Provided herein are substrates for matrix-assisted laser-desorption ionization (MALDI) mass spectrometric analysis. Each spot includes 3-hydroxypicolinic acid matrix and no analyte. |
| 7285422 |
Systems and methods for preparing and analyzing low volume analyte array elements |
October 23, 2007 |
| The invention provides methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can dispense a spot of fl |
| 7232688 |
Systems and methods for preparing and analyzing low volume analyte array elements |
June 19, 2007 |
| Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface. The resulting substrates are also provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. The tool can |
| 7198893 |
DNA diagnostics based on mass spectrometry |
April 3, 2007 |
| Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a |
| 7094943 |
Solution phase biopolymer synthesis |
August 22, 2006 |
| Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X.sup.1).sub.n, where |
| 7074563 |
Mass spectrometric methods for detecting mutations in a target nucleic acid |
July 11, 2006 |
| Provided herein are mass spectrometric methods for detecting a mutation in a target nucleic acid. In an embodiment, provided is a method which comprises digesting a target nucleic acid molecule; capturing digested fragments on a solid support that comprises oligonucleotides complemen |
| 7038103 |
Solution phase biopolymer synthesis |
May 2, 2006 |
| Multifunctional liquid phase carriers (LPCs) and methods of using LPCs for the preparation of biopolymers are provided. The LPCs are highly symmetrical compounds that possess more than two points of attachment for biopolymer synthesis. The LPCs have the formula Sp(X.sup.1).sub.n, where |
| 6991903 |
Solid phase sequencing of double-stranded nucleic acids |
January 31, 2006 |
| Methods for detecting and sequencing of target double-stranded nucleic acid molecules, nucleic acid probes and arrays of probes useful in these methods, and kits and systems that contain these probes are provided. The methods involve hybridizing the nucleic acids or nucleic acids which |
| 6828435 |
Combinatorial protecting group strategy for multifunctional molecules |
December 7, 2004 |
| The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or subsequently derivatized are provided. In one process, M is a multifunctional low molecula |
| 6818394 |
High density immobilization of nucleic acids |
November 16, 2004 |
| Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a v |
| 6730517 |
Automated process line |
May 4, 2004 |
| Fully automated modular analytical systems with integrated instrumentation for analysis of biopolymer samples, such as nucleic acids, proteins, peptides and carbohydrates, are provided. Analytical methods of detection and analysis, such as mass spectrometry, radiolabeling, mass tags, |
| 6602662 |
DNA diagnostics based on mass spectrometry |
August 5, 2003 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6589485 |
Solid support for mass spectrometry |
July 8, 2003 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Arrays of oligonucleotides for performing mass spectrometric analyses are provided. In one aspect, a solid support is provided that |
| 6569385 |
Systems and methods for preparing and analyzing low volume analyte array elements |
May 27, 2003 |
| Serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface are provided. The substrates surfaces can be flat or geometrically altered to include wells of receiving material. |
| 6500621 |
DNA diagnostics based on mass spectrometry |
December 31, 2002 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6485913 |
Systems and methods for performing reactions in an unsealed environment |
November 26, 2002 |
| Open systems for performing submicroliter reactions are provided. The systems can include a support for performing the reaction; a liquid dispensing system for dispensing a submicroliter amount of a liquid to a site on or in the support; a temperature controlling device for regulating |
| 6436635 |
Solid phase sequencing of double-stranded nucleic acids |
August 20, 2002 |
| This invention relates to methods for detecting and sequencing of target double-stranded nucleic acid sequences, to nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids o |
| 6428955 |
DNA diagnostics based on mass spectrometry |
August 6, 2002 |
| The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal ab |
| 6387628 |
Mass spectrometric detection of polypeptides |
May 14, 2002 |
| A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disea |
| 6322970 |
Mass spectrometric detection of polypeptides |
November 27, 2001 |
| A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disea |
| 6303309 |
Method for dissociating biotin complexes |
October 16, 2001 |
| A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed. |
| 6300076 |
DNA diagnostics based on mass spectrometry |
October 9, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6277573 |
DNA diagnostics based on mass spectrometry |
August 21, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6268144 |
DNA diagnostics based on mass spectrometry |
July 31, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6268131 |
Mass spectrometric methods for sequencing nucleic acids |
July 31, 2001 |
| A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts ob |
| 6258538 |
DNA diagnostics based on mass spectrometry |
July 10, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6238871 |
DNA sequences by mass spectrometry |
May 29, 2001 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 6235478 |
DNA diagnostics based on mass spectrometry |
May 22, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6225450 |
DNA sequencing by mass spectrometry |
May 1, 2001 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 6225061 |
Systems and methods for performing reactions in an unsealed environment |
May 1, 2001 |
| An open system is provided for performing a submicroliter reaction. An open system can contain a solid support having a target site for performing the reaction; a liquid dispensing system such as a nanoliter dispensing pipette for dispensing a submicroliter amount of a liquid to the targ |
| 6221605 |
DNA diagnostics based on mass spectrometry |
April 24, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6221601 |
DNA diagnostics based on mass spectrometry |
April 24, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6207370 |
Diagnostics based on mass spectrometric detection of translated target polypeptides |
March 27, 2001 |
| The invention provides a means of detecting and identifying mutations in a genetic region, and a means of quantifying the number of repeat units in, for example, a trinucleotide repeat, by transcription/translation of the genetic region into a target polypeptide. The method requires neit |
| 6197498 |
DNA diagnostics based on mass spectrometry |
March 6, 2001 |
| Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and sequences in the molecules are provided. Depending upon the sequence to be detected, the processes, for example, can be used to diagnose a genetic disease or a chromosomal a |
| 6194144 |
DNA sequencing by mass spectrometry |
February 27, 2001 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 6146854 |
Filtration processes, kits and devices for isolating plasmids |
November 14, 2000 |
| Processes, kits and preferred devices for rapidly isolating large numbers of plasmid DNAs from plasmid containing cells and for performing high throughput DNA sequencing are described. |
| 6140053 |
DNA sequencing by mass spectrometry via exonuclease degradation |
October 31, 2000 |
| The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally |
| 6133436 |
Beads bound to a solid support and to nucleic acids |
October 17, 2000 |
| Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased |
| 6074823 |
DNA sequencing by mass spectrometry via exonuclease degradation |
June 13, 2000 |
| The invention provides fast and highly accurate mass spectrometer based processes for directly sequencing a target nucleic acid (or fragments generated from the target nucleic acid), which by means of protection, specificity of enzymatic activity, or immobilization, are unilaterally |
| 6043031 |
DNA diagnostics based on mass spectrometry |
March 28, 2000 |
| The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal ab |
| 6024925 |
Systems and methods for preparing low volume analyte array elements |
February 15, 2000 |
| The invention provides, in one aspect, serial and parallel dispensing tools that can deliver defined and controlled volumes of fluid to generate multi-element arrays of sample material on a substrate surface. The substrates surfaces can be flat or geometrically altered to include wells |
| 6022688 |
Method for dissociating biotin complexes |
February 8, 2000 |
| A method for dissociating a complex of a biotin compound and a biotin-binding compound, by contacting the complex with an amine, is disclosed. |
| 5928906 |
Process for direct sequencing during template amplification |
July 27, 1999 |
| Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and perfonning high throughput DNA sequencing are described. |
| 5900481 |
Bead linkers for immobilizing nucleic acids to solid supports |
May 4, 1999 |
| Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased |
| 5872003 |
DNA sequencing by mass spectrometry via exonuclease degradation |
February 16, 1999 |
| Methods for determining the sequence of nucleic acids by cleaving the nucleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
| 5851765 |
DNA sequencing by mass spectrometry via exonuclease degradation |
December 22, 1998 |
| Methods for determining the sequence of nucleic acids by cleaving the nucleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
| 5807525 |
Apparatus and process for multi stage solid phase synthesis of long chained organic molecules |
September 15, 1998 |
| An apparatus and process are disclosed for optimizing the repetitive steps in a solid-phase oligonucleotide synthesis by continuous optical scanning of the effluent stream from the reaction module and by computerized processing and implementation of the scanning data. |
| 5691141 |
DNA sequencing by mass spectrometry |
November 25, 1997 |
| The invention describes a new method to sequence DNA. The improvements over the existing DNA sequencing technologies are high speed, high throughput, no electrophoresis and gel reading artifacts due to the complete absence of an electrophoretic step, and no costly reagents involving vari |
| 5622824 |
DNA sequencing by mass spectrometry via exonuclease degradation |
April 22, 1997 |
| Methods for determining the sequence of nucleic acids by cleaving the nueleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the |
