| Patent Number |
Title Of Patent |
Date Issued |
| 6579996 |
Process for removing free fatty acids from fats and oils of biological origin or their steam dis |
June 17, 2003 |
| A method for removing free fatty acids from fats or oils of biological origin or their steam distillates by extracting the free fatty acids with a mixture of basic organic nitrogen compounds and water as an extraction medium at a temperature below the boiling point of the organic nitroge |
| 6413970 |
Pharmaceutical composition for treating viral diseases |
July 2, 2002 |
| Use of 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy-acetic-acid, an individual optical isomer or a pharmaceutically acceptable salt thereof as an active ingredient for the production of a pharmaceutical composition for the treatment of diseases induced by the respirato |
| 6371480 |
Device for transporting sheet-like articles |
April 16, 2002 |
| A device for transporting sheetlike material is proposed wherein the material to be conveyed is always held between a conveyer belt (1) and a guide means (20) each lying against one of the opposite sides of the material (23). In order to maintain a reliable transport function even wi |
| 6191282 |
Substituted 5-membered ring heterocycles comprising a bicyclic or tricyclic group their preparat |
February 20, 2001 |
| 5-Membered ring heterocycle of the formula I, ##STR1##in which D includes a COOR.sup.15, CON(CH.sub.3)R.sup.15 or CONHR.sup.15 radical and R.sup.15 includes a 6-24 member bicyclic or tricyclic radical, compositions, preparation and use as inhibitors of thrombocyte aggregation, metast |
| 5981492 |
Substituted 5-membered ring heterocycles, their preparation and their use |
November 9, 1999 |
| The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of |
| 5803446 |
Method and apparatus for singling loose sheet material |
September 8, 1998 |
| A method for singling loose sheet material, in particular bank notes, wherein the sheet material is supplied in an input pocket in the form of a stack in a defined position for vertical feed of the sheet material to a singler. The sheet material is moved within the input pocket verticall |
| 5722083 |
Directing a subscriber toward a destination within an SDMA mobile radio network |
February 24, 1998 |
| A process for directing a subscriber toward a destination within an SDMA mobile radio network, and a processor-controlled facility (BSC) which operates accordingly are proposed. This facility contains a communications interface unit (IF1) for receiving a message that specifies a destinat |
| 5703050 |
Urea derivatives, their preparation and use |
December 30, 1997 |
| Urea derivates are disclosed having the formula (I). ##STR1## in which A, B, W, Z, R, R.sup.1, R.sup.2, R.sup.3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metas |
| 5686421 |
Hydantoin derivates |
November 11, 1997 |
| Hydantoin derivatives of the formula I ##STR1## in which n is 3 or 4, R.sup.1 is alkyl or a radical of the formula R'--NH--C.dbd.N--R" with R' and R" being hydrogen or alkyl, and R.sup.2 is hydrogen, --NH--CO--NH.sub.2 and optionally substituted alkyl, and a process for the prepa |
| 5681838 |
Substituted amino compounds, their preparation and their use as inhibitors of thrombocyte-aggreg |
October 28, 1997 |
| The present invention relates to novel substituted amino compounds of the formula I:as defined in the present application, and to a process for preparing such compounds. The invention also includes pharmaceutical compositions containing the present compounds, and the preparation of such |
| 5658935 |
Heterocycles, their preparation and their use |
August 19, 1997 |
| The invention concerns heterocyclic compounds of the general formula (I) in which A, B, R, R.sup.2, R.sup.3, W, Y, Z.sup.1, Z.sup.2 and r are as defined in the description, methods of preparing them and their use as inhibitors of thrombocyte aggregation, the metastization of carcinoma |
| 5554594 |
Imidazolidine derivatives |
September 10, 1996 |
| The present invention relates to compounds of the general formula I ##STR1## in which R, R.sup.1 to R.sup.4, r, Y, Z and W are defined as indicated in the description, a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells a |
| 5466669 |
Immunostimulatory agent |
November 14, 1995 |
| There is disclosed an immunostimulatory agent comprising a peptide derived from lactoferrin having activity to modulate the release of inflammatory mediators from cells of the immune system. The peptide promotes the release of leukotriene B4 from polymorphonuclear neutrophils induced by |
| 5466669 |
Immunostimulatory agent |
November 14, 1995 |
| There is disclosed an immunostimulatory agent comprising a peptide derived from lactoferrin having activity to modulate the release of inflammatory mediators from cells of the immune system. The peptide promotes the release of leukotriene B4 from polymorphonuclear neutrophils induced by |
| 5461035 |
Short peptides with insulin activity |
October 24, 1995 |
| A method for the treatment of diabetes mellitus or non-insulin-dependent diabetes comprising at least one peptide selected from the group consisting of Tyr-Gln-Leu-Glu-Asn-Tar-Cys-Asn, Acetyl-Leu-Glu-Asn-Tar-Cys-Asn OH, Asn-Tar-Cys-Asn, or a peptide of the formulaor the stereoisomeri |
| 5457033 |
Preparation of polypeptides having an amide carboxyl terminal end |
October 10, 1995 |
| Polypeptides having a carboxamide carboxyl terminal end and a methionine residue, which is optionally bonded to a bacterial protein, on the amino end can be prepared by synthesis by genetic engineering methods of the corresponding polypeptide having at the C terminal end a glycine residu |
| 5434138 |
Gonadoliberin antagonists |
July 18, 1995 |
| Peptides of the formula ##STR1## in which X is alkanoyl, A is optionally substituted D-Nal(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser (R.sup.1), F is Leu, Trp or Phe, G is L-Ser(R. |
| 5424293 |
Phenylimidazolidine derivatives and their use |
June 13, 1995 |
| Phenylimidazolidine derivatives of the general formula I ##STR1## in which, for example, Y denotes --CH.sub.2 --CH.sub.2 --CO--r denotes 0 to 3Z denotes oxygenW denotes hydroxylR.sup.1 denotes --NH--C(.dbd.NH)--NH.sub.2R, R.sup.2, R.sup.3 denote hydrogenR.sup.4 denotes --CO--NHR.sup.5,where |
| 5397796 |
2,4-dioxoimidazolidine compounds and compositions, and processes for administering same |
March 14, 1995 |
| The present invention relates to 2,4-dioxoimidazolidine compounds of the formula I ##STR1## a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces. |
| 5389614 |
Hydantoin derivatives |
February 14, 1995 |
| The invention relates to compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y have the meanings indicated in Claim 1, to processes for their preparation and their use as active pharmacological substances. |
| 5326875 |
Alkylation of azaglycine derivatives |
July 5, 1994 |
| A process for the preparation of alkylated azaglycine derivatives of the formula Iis described in which X is an amino protective group, C.sub.1 -C.sub.8 -alkanoyl, C.sub.6 -C.sub.14 -arylcarbonyl or C.sub.6 -C.sub.14 -aryl-C.sub.1 -C.sub.4 -alkanoyl, A is amino acid or imino acid radical |
| 5166394 |
Coupling reagent for peptide synthesis |
November 24, 1992 |
| Novel compounds of the formula I ##STR1## in which X is an anion, and a process for the preparation thereof, are described. Compounds of the formula I are used as coupling reagents in peptide synthesis. |
| 5093477 |
Rapidly cleavable substrate for HIV protease |
March 3, 1992 |
| A rapidly cleavable substrate for HIV protease Hepta- to nona-peptides of the formulain which A is absent or represents Val, Ile or Thr, B denotes Ser, Thr or Phe, D denotes Asp or Ala, E denotes Tyr or Phe, Opr denotes 5-oxaproline, F denotes Ile, Leu, Val, Thr or Gln, G denotes Val, Il |
| 5091367 |
Analogs of gonadoliberin with improved solubility, methods for their preparation, agents contain |
February 25, 1992 |
| The invention relates to peptides of the formula ##STR1## in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or |
| 5071836 |
Competitive gonadoliberin antagonists |
December 10, 1991 |
| Peptides of the formulain which X represents Tyr or His and Y represents Gly-NH.sub.2, D-Ala-NH.sub.2, Azgly-NH.sub.2 or NH--C.sub.2 H.sub.5 are competitive antagonists of Gn-RH. They are used for the treatment of gonadotropin- and steroid-dependent diseases and are prepared by known met |
| 5011825 |
Peptides influencing diuresis and natriuresis, a process for their preparation, agents containin |
April 30, 1991 |
| The invention relates to peptides of the formulain which R.sup.N denotes an acyl radical, L denotes a radical of a lipophilic, neutral .alpha.-amino acid, N denotes a radical of an neutral .alpha.-amino acid, B.sup.2 denotes the radical of a basic .alpha.-amino acid, and R.sup.C denotes |
| 4900658 |
Chromophoric peptides for detecting peptidylglycine-.alpha.-amidizing monooxygenase |
February 13, 1990 |
| A chromophoric peptide is prepared of the formulaand salts thereof in which R represents Gly-OH, NH.sub.2 or Gly-R.sup.2 wherein R.sup.2 denotes a carboxyl protective group, and DIS denotes 5-dimethylaminonaphthalene-1-sulfonyl. The enzyme, peptidylglycine-.alpha.-amidizing monooxygenase |
| 4861755 |
Peptides with vasorelaxant, natriuretic and diuretic effects a process for their preparation, ag |
August 29, 1989 |
| The invention relates to new peptides of the formula ##STR1## in which X, A, B, C, N', E, F, G and Z have the meanings indicated in the description, to a process for their preparation, to agents containing them, and to their use. |
| 4806641 |
Salts of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine and amino compounds |
February 21, 1989 |
| The invention relates to salts of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOObt) and compounds containing a primary amino group, a process for their preparation and their use. |
| 4788178 |
Use of gonadoliberin and gonadoliberin agonists for the treatment of climacteric complaints |
November 29, 1988 |
| The invention relates to the use of gonadoliberin and gonadoliberin agonists for the treatment of climacteric complaints and pathological conditions in which the level of parathyroid hormone is elevated, and to preparations containing this or these compounds(s). |
| 4755591 |
Process for the preparation of peptides by use of perchlorates |
July 5, 1988 |
| The invention relates to a process for the preparation of protected arginine-containing peptides by fragment coupling, at least one arginine-containing fragment being reacted as perchlorate, and to protected secretin derivatives of the formula I described. |
| 4711847 |
Preparation of secretin |
December 8, 1987 |
| Secretin, which cannot be prepared directly by genetic engineering because of its carboxylic acid carboxyl-terminus, can be obtained by preparing secretylglycine by genetic engineering and then obtaining secretin therefrom by enzymatic conversion of the terminal glycine radical. The |
| 4658016 |
Process for the preparation of pentapeptides having an action on the immune system and intermedi |
April 14, 1987 |
| The invention relates to a process for the preparation of peptides of the general formulain which S denotes glutamic acid or .alpha.-aminoadipic acid and Y denotes tyrosine or tryptophan or esters or amides thereof, which comprises subjecting tetrapeptides of the formulain which Z' repre |
| 4621073 |
Cyclic peptides having somatostatin activity |
November 4, 1986 |
| The invention relates to cyclic hexapeptides of the general formula III ##STR1## in which X represents the radical of an L-aminoacid of the general formula IIIa ##STR2## in which A and B are identical or different and denote alkyl having 1 to 3 carbon atoms, or A and B togeth |
| 4487764 |
New peptides and a process for their preparation |
December 11, 1984 |
| A peptide of the formulain whichB.sub.1 denotes a basic aminoacid,B.sub.2 denotes a basic aminoacid,A.sub.1 denotes an aromatic aminoacid,A.sub.2 denotes an aromatic aminoacid andX denotes an aminoacid in which the carboxyl group can be esterified, a process for the preparation thereof and the u |
| 4478828 |
Nonapeptide having immunostimulative activity, process for the preparation thereof, and its use |
October 23, 1984 |
| The invention provides a nonapeptide of the formula Ia process for the preparation thereof and its use, furthermore intermediates for preparing a compound of the formula I. |
| 4474691 |
Chromophoric peptides, a process for their preparation, agents containing them and their use for |
October 2, 1984 |
| The invention relates to chromophoric peptides of the general formula I ##STR1## in which n represents 1 or 2, a porcess for their preparation, agents containing them and their use for determining DD-carboxypeptidases. |
| 4420424 |
New peptides and a process for their preparation |
December 13, 1983 |
| What are disclosed are pentapeptides, useful for influencing the maturing of T-lymphocytes, of the formulawhereinG is arginine, lysine, ornithine, or homoarginine, or is an unsubstituted or substituted .omega.-aminoalkanoyl, .omega.-guanidinoalkanoyl, or .omega.-dimethylaminoalkanoyl;K i |
| 4395400 |
Nonapeptide, a process for its preparation, an agent containing it and its use |
July 26, 1983 |
| What are disclosed are a nonapeptide of the formula ##STR1## wherein D-Aad (OBu.sup.t) represents D-.alpha.-aminoadipic acid .delta.-tert. butyl ester, methods for making this peptide, pharmaceutical preparations containing this peptide, and methods for its use in increasing fert |
| 4275001 |
Process for the manufacture of LH-RH and LH-RH analogs using Glu-His(DnP)-OH |
June 23, 1981 |
| What is disclosed is a method for the manufacture of LH-RH and LH-RH analogs, which comprises reacting Glu-His(DnP)-OH with the corresponding peptide having a free amino group and protected carboxy groups in a solvent as used in peptide chemistry and with the addition of 3-hydroxy- |
| 4215037 |
Partially protected human insulin-A-chain and process for its manufacture |
July 29, 1980 |
| Partially protected human insulin-A-chain suitable as intermediate for insulin synthesis and process for its manufacture by reacting the partially protected peptide fragment 6 to 26 of the insulin-A-chain with the peptide fragment 1 to 5 containing an N-terminal amino protective grou |
| 4212796 |
Process for the preparation of cysteine-containing peptides |
July 15, 1980 |
| A process for the preparation of cysteine-containing peptides by detachment of the S-trityl groups by means of trifluoroacetic acid, wherein S-trityl compounds of these peptides are treated with a mixture of a mercaptan and trifluoroacetic acid. |
| 4118483 |
Peptides having gonadoliberin activity and process for their manufacture |
October 3, 1978 |
| A peptide with LH-RH-activity which is a LH-RH-peptide wherein Gly in 6-position is replaced by D-glutaminic-acid which may be N-substituted at the CO-NH.sub.2 moiety, wherein in 10-position Gly-NH.sub.2 may be replaced by a NH-alkyl or NH-cycloalkyl group and/or wherein the amino ac |
| 4098779 |
Process for the purification and manufacture of secretin |
July 4, 1978 |
| A process for the purification of secretin by chromatography on an alkylated dextran gel is disclosed, as is a method of its manufacture appropriate for preparing larger amounts of secretin. |
| 4053588 |
Pharmaceutical preparations having psychotropic activity and process for their manufacture |
October 11, 1977 |
| Pharmaceutical preparations containing an L-pyroglutamic acid amide, processes for their preparation and methods of treating psychotic diseases with them. |
| 4052164 |
Apparatus for centrifugal separation and measurement of samples |
October 4, 1977 |
| A rotor, adapted for rotation at high speeds, has symmetrically arranged radial channels for receiving tubular containers of material to be evaluated such for example as samples of blood. The outer end of each radially extending container filled with the sample to be evaluated is pla |
| 4024248 |
Peptides having LH-RH/FSH-RH activity |
May 17, 1977 |
| The present invention relates to peptides having strong LH-RH/FSH-RH activity, wherein Gly in the 6-position is replaced by different substituted amino acids and in the 10-position there is glycinamide or glycine in the 10-position is replaced by a NH-alkyl group with 1-3 carbon atom |
| 4003884 |
Peptides having LH-RH/FSH-RH activity |
January 18, 1977 |
| Peptides having LH-RH/FSH-RH activity useful for treatment of male and female sterility. |
| 3992529 |
Method of treating excessive fibrinolysis with synthetically modified trypsin inhibitors |
November 16, 1976 |
| Method of treating excessive fibrinolysis with a modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated bywherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W |
| 3953417 |
Synthetically modified trypsin inhibitors and process for preparing them |
April 27, 1976 |
| Modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated byWherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub. |
