| Patent Number |
Title Of Patent |
Date Issued |
| 5147868 |
Thienamycin renal peptidase inhibitors |
September 15, 1992 |
| Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates. |
| 5071843 |
Combination of 2-substituted carbapenems with dipeptidase inhibitors |
December 10, 1991 |
| A combination of a carbapenem of the formula: ##STR1## where R is H or CH.sub.3 and R.sup.1 is ##STR2## with a renal dipeptidase inhibitor is disclosed. |
| 4880793 |
Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
November 14, 1989 |
| A novel antibacterial drug combination is provided, one component being a 2-substituted penem, and the other component is a dipeptidase (E.C.3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 parts by weight of the penem are employed for 30 to 1 parts by |
| 4668504 |
Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics |
May 26, 1987 |
| Antibiotics to prevent nephrotoxicity. |
| 4616038 |
Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
October 7, 1986 |
| Antibacterial compositions of thienamycin-type compounds and a dipeptidase (E.C.3.4.13.11) inhibitor. |
| 4539208 |
Combination of thienamycin-type antibiotics with dipeptidase inhibitors |
September 3, 1985 |
| A novel antibacterial drug combination is provided, one component being a fused ring .beta.-lactam, such as thienamycin and its semi-synthetic derivatives, and the other component is a dipeptidase (E.C. 3.4.13.11) inhibitor. The dual-component combination is formulated so that 1 to 3 |
| 4304867 |
Culture of Streptomyces cattleya |
December 8, 1981 |
| The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media. |
| 4282322 |
Process for enzymatic deacylation of antibiotics |
August 4, 1981 |
| This invention relates to two new antibiotics, desacetyl 890A.sub.1 and desacetyl 890A.sub.3, active against both gram-positive and gram-negative bacteria, which are produced by treating 890A.sub.1 and 890A.sub.3, respectively, with an N-acetylthienamycin amidohydrolase produced by a |
| 4264734 |
Process for producing antibiotic desacetyl 890A.sub.10 |
April 28, 1981 |
| This invention relates to the new antibiotic, desacetyl 890A.sub.10, active against both gram-positive and gram-negative bacteria, which is produced by treating 890A.sub.10 with an N-acetyl-890A.sub.10 amidohydrolase produced by a soil microorganism isolated by enrichment techniques. Thi |
| 4229534 |
Acetylthienamycin production |
October 21, 1980 |
| The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antiobiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of |
| 4165379 |
N-acetyl thienamycin |
August 21, 1979 |
| The antibiotic N-acetyl thienamycin and its non-toxic pharmaceutically acceptable salts are active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a species of Streptomyces on suitable fermentation media or alternatively by acetylation of |
| 4162193 |
Enzymatic cleavage of N-acyl-thienamycins |
July 24, 1979 |
| A method is disclosed for cleaving N-acyl-thienamycin compounds to yield thienamycin. The new method disclosed herein utilizes enzymes which are penicillin amidohydrolases to treat the starting compounds resulting in the antibiotic thienamycin. |
| 4135978 |
Production of N-acyl-thienamycins |
January 23, 1979 |
| The disclosed invention is directed to a process for preparing N-acyl-thienamycins from thienamycin and the appropriate acyl group by reacting the same in the presence of certain penicillin amidohydrolases capable of producing N-acyl thienamycins. |
| 4081548 |
Antibiotics |
March 28, 1978 |
| The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media. |
| 4031231 |
Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with au |
June 21, 1977 |
| Novel antibacterial compositions are prepared by combining 3-fluoro-D-alanine-type compound, such as 3-fluoro-D-alanine and its deutero analogs, and salts and esters thereof, with a 3-fluoro-D-alanine autoantagonist-inhibitor such as cycloserine-type compound. The compositions demons |
| 4028405 |
Fluorinated amino acids |
June 7, 1977 |
| Deutero analogs of 3-fluoro-D-alanine prepared by direct photofluorination of the D-amino acids demonstrate in vivo and in vitro antibacterial activity against both gram negative and gram positive microorganisms. Deuters analogs of 3-fluoro-L-alanine and 3-fluoro-D,L-alanine also dem |
| 4006060 |
Thienamycin production |
February 1, 1977 |
| The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media. |
| 4000161 |
Process for purifying thienamycin |
December 28, 1976 |
| Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using ion exchange resins, poly-acrylamide gels or adsorbents such as polyester polymers or polystyrene, hydrophobic |
| 3950357 |
Antibiotics |
April 13, 1976 |
| The antibiotic thienamycin is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing a newly-found and hitherto undescribed species of Streptomyces on suitable fermentation media. |
