| Patent Number |
Title Of Patent |
Date Issued |
| 7425319 |
Method for enhancing protective cellular responses to genotoxic stress in skin |
September 16, 2008 |
| The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. Th |
| 7226937 |
Methods for modulating phototoxicity |
June 5, 2007 |
| The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light. |
| 7217739 |
Method for inducing cell death with carbonyl scavengers |
May 15, 2007 |
| Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells without having a parallel effect on normal cells. As such, they are useful therapeutic a |
| 6992071 |
Methods for modulating phototoxicity |
January 31, 2006 |
| The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light. |
| 6924299 |
Methods and compositions useful in enhancing oxygen delivery to cells |
August 2, 2005 |
| The invention discloses compositions and methods which are useful in improving delivery of oxygen to cells. The compositions require at least one derivative of a compound. The derivatives are chosen to have log P values below about 6.0. |
| 6906180 |
Genes encoding several poly(ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragment |
June 14, 2005 |
| The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's |
| 6716635 |
Method for identifying regulators of protein-advanced glycation end product (protein-AGE) format |
April 6, 2004 |
| The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. |
| 6677361 |
Topical formulations for the transdermal delivery of niacin and methods of treating hyperlipidem |
January 13, 2004 |
| Niacin and niacin prodrugs are topically administered as suitable formulations to device for impoving the lipid profiles of subjects, preferably humans. |
| 6552050 |
Method for enhancing protective cellular responses to genotoxic stress in skin |
April 22, 2003 |
| The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The |
| 6495537 |
Method for inhibition of photocarcinogenesis or photoimmunosuppression using niacin |
December 17, 2002 |
| The invention is directed to novel methods for the suppression of photocarcinogenesis and photoimmunosuppression in mice. The novel methods comprises the step of administering to a subject a pharmaceutical composition comprising niacin and a pharmaceutical carrier. |
| 6464992 |
Topical micronutrient delivery system and uses thereof |
October 15, 2002 |
| The invention involves methods and compositions useful in delivering micronutrients to cells. By formulating the micronutrient in the form of an ester that is convertible to the active form of the micronutrient, one can combine it with a co-ester that inhibits esterases, so that the |
| 6428972 |
Biochemical method to measure niacin status in a biological sample |
August 6, 2002 |
| The invention relates to assay or determining intercellular niacin status in solid tissues. One extracts intracellular pyredine nucleotides, cycles these, in the presence of agents which reduce the pyredine nucleotides and a dye, which reflect the change. Changes in absorbance of the dye |
| 6417235 |
Method and use of .alpha.-amino-.beta.-mercapto-ethane derivatives as dicarbonyl scavengers for |
July 9, 2002 |
| Methods of inhibiting damage to proteins, lipids, and DNA by the use of penicillamines and other .alpha.-amino-.beta.,.beta.-mercapto-.beta.,.beta.-dimethyl-ethane compounds as dicarbonyl scavengers is disclosed. |
| 6403619 |
Method for controlling cell necrosis or apoptosis |
June 11, 2002 |
| The invention relates to the manipulation of enzymatic pathways, such as poly (ADP-ribose) polymerase pathways, which are dependent upon NAD as a substrate. By administering pro-NAD compounds, cell death caused by necrosis and/or apoptosis can be reduced. Further, by inhibiting one or |
| 6395543 |
Genes encoding several poly(ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragment |
May 28, 2002 |
| The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's |
| 6337202 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragmen |
January 8, 2002 |
| The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's |
| 6337065 |
Method for enhancing protective cellular responses to genotoxic stress in skin |
January 8, 2002 |
| The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The |
| 6333148 |
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragmen |
December 25, 2001 |
| The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described. PARG is involved in the cellular response to DNA damage and its proper function is associated with the body's |
| 6287796 |
Biochemical method to measure niacin status in a biological sample |
September 11, 2001 |
| The present invention is a novel and rapid assay for intracellular niacin status in a biological sample that is both highly sensitive and accurate over a wide range of niacin status. The assay can be performed directly on a biological sample such as blood and is useful for determining th |
