| Patent Number |
Title Of Patent |
Date Issued |
| 6833364 |
Substituted pyrazole derivatives |
December 21, 2004 |
| The present invention relates to novel substituted pyrazole derivatives of the general formula (I) ##STR1##in which the substituents R.sup.1, R.sup.2, R.sup.3, A, X and Y are each as defined, and to processes for their preparation and to their use as medicaments, in particular as med |
| 6743798 |
Substituted pyrazole derivatives condensed with six-membered heterocyclic rings |
June 1, 2004 |
| The present invention relates to novel substituted pyrazole derivatives of the general formula (I) ##STR1##in which R.sup.1, R.sup.2, R.sup.3 and A are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatm |
| 6649618 |
Substituted amidoalkyl-uracils and their use |
November 18, 2003 |
| Novel amidoalkyl-uracil derivatives of the formula (I) ##STR1##in which A represents 1-3 ring atoms and X represents optionally substituted (C.sub.2 -C.sub.10)alkylene or (C.sub.3 -C.sub.8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicame |
| 6462068 |
Heterocyclylmethyl-substituted pyrazole derivatives |
October 8, 2002 |
| The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases. |
| 6451805 |
Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases |
September 17, 2002 |
| The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders. |
| 6414009 |
Heterocyclylmethyl-substituted pyrazol derivatives |
July 2, 2002 |
| The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases. |
| 6410740 |
Heterocyclylmethyl-substituted pyrazol derivatives |
June 25, 2002 |
| The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases. |
| 6387940 |
Heterocyclylmethyl-substituted pyrazole derivatives |
May 14, 2002 |
| The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases. |
| 6180656 |
Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special disea |
January 30, 2001 |
| The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) ##STR1##in which R.sup.1 to R.sup.4 have the meaning indicated in the description, as medicaments, and to new active compou |
| 6166027 |
Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular di |
December 26, 2000 |
| The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases. |
| 5861396 |
Purin-6-one derivatives |
January 19, 1999 |
| Purin-6-one derivatives are prepared by acylating appropriately substituted imidazole carboxamides and then cyclizing to give the purines. The purin-6-one derivatives are suitable as active compounds in medicaments, in particular for the treatment of cardiovascular disorders, disorders o |
| 5721248 |
4-bicyclically substituted dihydropyridines, and their use in medicaments |
February 24, 1998 |
| The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatm |
| 5629320 |
3-quinolyl-substituted dihydropyridines, and their use in medicaments |
May 13, 1997 |
| This invention relates to 3-quinolyl-substituted dihydropyridine derivatives, such as ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are used in treating cardiovascular disease. |
| 5550245 |
3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medica |
August 27, 1996 |
| Intermediate of the formula ##STR1## wherein R.sup.5 represents a cyclic, straight-chain or branched, saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, which is optionally interrupted up to twice in an identical or different manner by oxygen or sulphur, a |
| 5545646 |
4-bicyclically substituted dihydropyridines and their use in medicaments |
August 13, 1996 |
| The invention relates to new 4-bicyclically substituted dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.5 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in agents for the treatm |
| 5514803 |
2,6-disubstituted 4-quinolyl-dihydropyridines |
May 7, 1996 |
| The invention relates to new 2,6-disubstituted 4-quinolyl-dihydropyridines ##STR1## in which R.sub.1 to R.sub.5 have the meaning indicated in the description,processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular di |
| 5508406 |
Quinolyl-dihydropyridine esters, processes for their preparation, and their use in medicaments |
April 16, 1996 |
| The invention relates to new 4-quinolyl-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.6 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of |
| 5504210 |
3-quinolyl-substituted dihydropyridines and their use in medicaments |
April 2, 1996 |
| The invention relates to new 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5504209 |
2-amino-5-cyano-4-quinolydihydropyridine esters, processes for their preparation and their use i |
April 2, 1996 |
| The present invention relates to new 2-amino-5-cyano-4-quinolyl-l, 4-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in |
| 5502062 |
2-amino-4-quinolyl-dihydropyridines, processes for their preparation, and their use |
March 26, 1996 |
| The present invention relates to new 2-amino-4-quinolyl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 -R.sub.4 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the t |
| 5478937 |
Certain cinnoline carboxaldehydes and naphthyridine carboxaldehydes useful as intermediates |
December 26, 1995 |
| The present invention relates to new 2-amino-4-heteroaryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions fo |
| 5436342 |
Condensed quinolyl-dihydropyridines, processes for their preparation and their use in medicament |
July 25, 1995 |
| The invention relates to novel, condensed 4-quinolyl-dhydropyridines of the general formula (I) ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in agents |
| 5434153 |
2-amino-4-heteroaryl-1,4-dihydropyridines and their use in medicaments |
July 18, 1995 |
| The present invention relates to new 2-amino-4-hetero-aryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions f |
| 5432282 |
Process for preparing 1,4-dihydro-2-amino-3-carboxy-5-cyano-pyridine derivatives |
July 11, 1995 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5428061 |
Organic nitrates and method for their preparation |
June 27, 1995 |
| New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, high blood |
| 5420142 |
Certain 3-formyl-1, 4-dihydropyridines and their pharmaceutical composition and use |
May 30, 1995 |
| The present invention relates to the use of 3-formyl-1,4-dihydropyridine derivatives as medicaments for the control of cardiovascular diseases, in particular of pathologically changed blood pressure and of cardiac insufficiency, new compounds and a process for their preparation. |
| 5412099 |
Intermediate benzothiazolyl- and benzoxazolyl-aldehyde compounds |
May 2, 1995 |
| Intermediate compounds of formula IIwherein R.sup.3 is ##STR1## and R.sup.6 and R.sup.7 are as defined in the specification, are useful to make compounds having cardiovascular activity. |
| 5410055 |
3-phenyl-1,7-naphthyridine and cinnoline-5-carboxyaldehyde intermediates for medicaments |
April 25, 1995 |
| The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and intermediates thereof and to their use in medicaments, |
| 5380851 |
2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation |
January 10, 1995 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5374647 |
Antithrombotic substituted cycloalkano (B) dihydroindole sulphonamides |
December 20, 1994 |
| Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X i |
| 5364855 |
4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines, processes for their preparation and their u |
November 15, 1994 |
| The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in compositi |
| 5262429 |
Aryl-quinolyl-substituted 1,4-dihydropyridine-dicarboxylic acid compounds which have useful phar |
November 16, 1993 |
| The invention relates to novel aryl-quinolyl-substituted 1,4-dihydropyridine-di-carboxylic acid derivatives, to processes for their preparation and to their use in drugs, especially for the preparation drugs for the treatment of cardiovascular diseases. |
| 5254692 |
2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
October 19, 1993 |
| 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl hav |
| 5225558 |
2-amino-5-cyano-1,4-dihydropyridines, and their use in medicaments |
July 6, 1993 |
| The present invention relates to new 2-amino-5-cyano-4-quinoline-1,4-dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases. |
| 5204472 |
Quinoline and isoquinoline intermediates |
April 20, 1993 |
| Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a la |
| 5200420 |
2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines |
April 6, 1993 |
| 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl hav |
| 5100900 |
Positive inotropically active 4-quinolyl-dihydropyridines and use thereas |
March 31, 1992 |
| Positive inotropically active 4-quinolyl-dihydropyridines of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a la |
| 5096897 |
Antithrombotic substituted cycloalkano(b)dihydroindole- and -indole-sulphonamides |
March 17, 1992 |
| Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X |
| 5039670 |
Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use |
August 13, 1991 |
| Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X i |
