| |
 |
Gerhard Hofle Patents |
|
Inventor: Hofle; Gerhard
Address: Braunschweig, DE
No. of patents: 18
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 6831090 |
2,3-olefinic epothilone derivatives |
December 14, 2004 |
| The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure, ##STR1##which have microtubule-stabilizing effe |
| 6593115 |
Preparation of epothilone intermediates |
July 15, 2003 |
| The present invention relates to a process for the preparation of intermediates useful in the synthesis of epothilone analogs by initially enzymatically degrading certain epothilone compounds to form ring-open structures containing a carboxyl group which is esterified, the hydroxyl g |
| 6498257 |
2,3-olefinic epothilone derivatives |
December 24, 2002 |
| The present invention relates to 2,3-position modified epothilone derivatives, methods of preparation of the derivatives, and intermediates therefor. The compounds of the invention as 16-membered macrolides having the general structure, ##STR1##which have microtubule-stabilizing effe |
| 6399638 |
12,13-modified epothilone derivatives |
June 4, 2002 |
| The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor. |
| 6380395 |
12, 13-cyclopropane epothilone derivatives |
April 30, 2002 |
| The present invention relates to 12,13-position modified epothilone derivatives, methods of preparation of the derivatives and intermediates therefor. |
| 6359140 |
Epothilones with modified side chain |
March 19, 2002 |
| Epothilones with a modified side chain and process for the preparation thereof are disclosed. |
| 5622979 |
Thiangazole, its preparation, compositions and use thereof |
April 22, 1997 |
| The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and composi |
| 5610038 |
Thiangazole, its preparation, compositions and use thereof |
March 11, 1997 |
| The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and composi |
| 5604249 |
Thiangazole, its preparation, compositions and use thereof |
February 18, 1997 |
| The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and composi |
| 5096922 |
Macrocyclic antibodies |
March 17, 1992 |
| The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration;R.sub.1 i |
| 5093358 |
Macrocyclic plant acaricides |
March 3, 1992 |
| Compounds of the formula I ##STR1## in which either R is methyl and there is a double bond in the 9,10-position, or in which R is hydrogen and there is a single bond in the 9,10-position, are highly active against Acarina which damage plants. |
| 5026878 |
Process for preparing soraphen compounds |
June 25, 1991 |
| Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted |
| 5023184 |
Antibiotics from myxococcus |
June 11, 1991 |
| The invention relates to novel polycyclic alkaloids of formula ##STR1## in which R.sup.1 represents hydrogen or hydroxy, R.sup.2 represents hydrogen or acyl and A and B, independently of one another, each represents C.dbd.O or C--OH, and wherein the dashed line represents a C.dbd |
| 4997820 |
Microbicides |
March 5, 1991 |
| Novel macrocyclic compounds of the formual I ##STR1## where the dotted line in the 9,10-position is a saturated bond or a double bond, alternatively, and R is hydrogen, methyl or certain acyl radicals, and R.sub.o is hydrogen, halogen, azido, thiol, hydroxyl or --OY, where Y is, |
| 4987149 |
Soraphen compounds and their use as microbicides |
January 22, 1991 |
| Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted |
| 4987072 |
Macrocyclic antibiotics |
January 22, 1991 |
| The invention relates to cyclic antibiotics of formula ##STR1## wherein the prefix R represents that the substituents on the adjacent carbon atom are in the R configuration; the prefix S represents that the substituents on the adjacent carbon atom are in the S configuration; R.su |
| 4954517 |
Microeicides |
September 4, 1990 |
| A macrocyclic compound of the formula I, ##STR1## in which the substituents have the following meaning: X is hydrogen or methyl, Y is hydrogen, --CHO, --COCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2, benzyl, methyl or a silyl group, and A--B--C |
| 4940804 |
Microbicides |
July 10, 1990 |
| Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted |
|
|
|
