| Patent Number |
Title Of Patent |
Date Issued |
| 7378511 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
May 27, 2008 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 7375187 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
May 20, 2008 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 7368536 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
May 6, 2008 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 7309811 |
Transgenic mice knockouts of BACE-1 |
December 18, 2007 |
| The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The transgenic animals are |
| 7205120 |
Substrates and assays for .beta.-secretase activity |
April 17, 2007 |
| The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a .beta.-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed. |
| 7041473 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
May 9, 2006 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protein and associat |
| 6913918 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
July 5, 2005 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6867018 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
March 15, 2005 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6835565 |
Alzheimer's disease secretase |
December 28, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. |
| 6828117 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
December 7, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6825023 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
November 30, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6797487 |
Polynucleotides encoding alzheimer's disease secretase |
September 28, 2004 |
| The present invention provides methods of reducing cellular production of amyloid beta (A.beta.) from amyloid precursor protein (APP) by reducing Asp2 transcription or translation in cells. |
| 6790610 |
Alzheimer's disease, secretase, APP substrates therefor, and uses therefor |
September 14, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6753163 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
June 22, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6737510 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
May 18, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6730778 |
Human sel-10 polypeptides and polynucleotides that encode them |
May 4, 2004 |
| The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isola |
| 6727074 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
April 27, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6706485 |
Method of identifying agents that inhibit APP processing activity |
March 16, 2004 |
| The present invention provides methods of identifying agents that inhibit the amyloid precursor protein (APP) processing activity of Asp2 polypeptide. |
| 6699671 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
March 2, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6638731 |
Human sel-10 polypeptides and polynucleotides that encode them |
October 28, 2003 |
| The present invention provides isolated nucleic acid molecules comprising a polynucleotide encoding either of two alternative splice variants of human sel-10, one of which is expressed in hippocampal cells, and one of which is expressed in mammary cells. The invention also provides isola |
| 6500667 |
Aspartyl protease 2 (Asp2) antisense oligonucleotides |
December 31, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6440698 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
August 27, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6420534 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
July 16, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
