| Patent Number |
Title Of Patent |
Date Issued |
| 7371734 |
Oligonucleotide compositions and their use for the modulation of immune responses |
May 13, 2008 |
| The present invention relates to 3'-OH, 5'-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating antigen presenting cells in the individual. In one embodiment, the antigen presenting cell is a dendr |
| 7200531 |
Conformation-activity relationship of apoptosis-inducing phosphodiester oligonucleotides |
April 3, 2007 |
| The present invention facilitates in silico evaluation of molecules for biological activity by providing a computer-based method to predict whether oligonucleotides may possess biological activity and the efficacy of the biological activity based on the three-dimensional structure and |
| 7199228 |
Oligonucleotide compositions and their use to induce apoptosis |
April 3, 2007 |
| The present invention provides novel synthetic oligonucleotide sequences (hereinafter sequence) of 3 to 9 bases in length comprising one or more non-DNA bases wherein the bases are nebularine, hypoxanthine, or uracil, or combinations of nebularine, hypoxanthine and uracil bases. These |
| 7157436 |
Therapeutically useful synthetic oligonucleotides |
January 2, 2007 |
| The present invention provides a composition and method comprising a 2 20 base 3'-OH, 5'-OH synthetic oligonucleotide (sequence) selected from the group consisting of (G.sub.xT.sub.y).sub.n, (T.sub.yG.sub.x).sub.n, a(G.sub.xT.sub.y).sub.n, a(T.sub.yG.sub.x).sub.n, (G.sub.xT.sub.y).su |
| 7125858 |
Hyaluronic acid in the treatment of cancer |
October 24, 2006 |
| The present invention relates to a composition and method comprising purified HA, a second anti-neoplastic agent and a pharmaceutically acceptable carrier, wherein the purified HA and the second anti-neoplastic agent are administered to a mammal having cancer in an amount effective t |
| 7087586 |
Oligonucleotide compositions and their use to induce differentiation of cells |
August 8, 2006 |
| The present invention provides compositions comprising a 3'-OH, 5'-OH, chemically unmodified, synthetic phosphodiester nucleotide sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, and a pharmaceutically acceptable carrier, wher |
| 6890911 |
Method for the treatment of inflammation |
May 10, 2005 |
| The present invention relates to a mycobacterial deoxyribonucleic acid (B-DNA) preserved and complexed on the mycobacterial cell wall (BCC) and a pharmaceutically acceptable carrier, wherein the BCC is effective in treating an inflammation in an animal having an inflammation. More pa |
| 6809081 |
Chemotherapeutic composition and method |
October 26, 2004 |
| The present invention relates to a composition and method comprising Mycobacterium phlei (M. phlei)-DNA (M-DNA), M-DNA preserved and complexed on M. phlei cell wall (MCC), a chemotherapeutic agent and a pharmaceutically acceptable carrier, wherein the M-DNA and the MCC induce cell cy |
| 6794368 |
Composition and method for inducing apoptosis in prostate cancer cells |
September 21, 2004 |
| The present invention relates to a composition and method useful for regulating cell proliferation and cell death in a multicellular organism. The present invention particularly relates to a composition comprising a bacterial DNA (B-DNA) and a first pharmaceutically acceptable carrier, |
| 6329347 |
Composition and method for the treatment of bladder cancer |
December 11, 2001 |
| The present invention relates to a composition and method useful for treating cancer in the urinary bladder. The present invention particularly relates to a composition comprising a Mycobacterium phlei deoxyribonucleic acid (M-DNA)-Mycobacterium phlei cell wall complex (MCC), wherein the |
| 6326357 |
Bacterial cell complex composition and method of use |
December 4, 2001 |
| The present invention relates to a composition and method useful for stimulating the immune system and for inhibiting proliferation of and inducing apoptosis in responsive cells of an animal. The present invention further relates to a composition comprising a Mycobacterium phlei deox |
