| Patent Number |
Title Of Patent |
Date Issued |
| 7371729 |
Boronic acid salts useful in parenteral formulations |
May 13, 2008 |
| Salts of a peptide boronic acid drug, for example of Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH).sub.2. The counter-ion to the boronate may be an alkali metal or derived from a strongly basic organic nitrogen-containing compound. |
| 7112572 |
Multivalent metal salts of boronic acids |
September 26, 2006 |
| Salts of a pharmaceutically acceptable divalent metal and an organoboronic acid drug. Examples of such metals are calcium, magnesium and zinc. The organoboronic acid drug may be a boropeptide protease inhibitor. The salts may be formulated in oral dosage form. |
| 6387881 |
Inhibitors and substrates of thrombin |
May 14, 2002 |
| Peptides which act as inhibitors or substrates of thrombin are provided. The peptides of the invention have the general structural formula: ##STR1## |
| 6127340 |
Serine protease inhibitors |
October 3, 2000 |
| This invention is directed to peptide inhibitors of serine proteases, espcecially thrombin, in which the P1-P2 natural amide linkage is replaced by another bond. Exemplary thrombin inhibitors have the formula: X-(aa.sup.3)-(aa.sup.2)-.psi.-(aa.sup.1)-Z wherein X is H or a substituent |
| 5858979 |
Inhibitors and substrates of thrombin |
January 12, 1999 |
| This invention provides peptides of the formula ##STR1## wherein X is H, CH.sub.3 or an N-protecting group;Y is(1) C.sub.3 -C.sub.9 alkyl optionally substituted by C.sub.1 -C.sub.4 alkoxy,(2) C.sub.5 -C.sub.10 aryl optionally substituted by C.sub.1 -C.sub.4 alkoxy,(3) C.sub.5 -C.sub. |
| 5648338 |
Inhibitors and substrates of thrombin |
July 15, 1997 |
| Peptides which act as inhibitors or substrates of thrombin are derived from the formula: D-Phe-Pro-Arg or its analogues, wherein Phe is substituted by (a), wherein Ar.sub.1 or Ar.sub.2 are the same or different and are selected from the group consisting of phenyl, thienyl, pyridyl, napht |
