| Patent Number |
Title Of Patent |
Date Issued |
| 6013645 |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide d |
January 11, 2000 |
| The present invention relates certain mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholestrolemia. |
| 5624921 |
Hypotriglyceridemic aminoacetylmercapto derivatives |
April 29, 1997 |
| The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia. |
| 5602122 |
Method for lowering total serum cholesterol and treating hypercholesterolemia with aminoacetylme |
February 11, 1997 |
| The present invention relates to the use of certain aminoacetylmercapto derivatives in treating patients suffering from hypercholesterolemia. |
| 5541201 |
Antiarrhythmic piperidin-1-yl-2,2-dialkylpropanone arylsulfonamide derivatives |
July 30, 1996 |
| The invention is directed to a new class of antiarrhythmic agents of the formula: ##STR1## in which R is represented by hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, CF.sub.3, SR.sub.1, NHC(O)R.sub.2, NH.sub.2, or OH; R.sub.1 is hydrogen or C.sub.1-4 alkyl; R.sub.2 is C.s |
| 5500433 |
Method of treating drug abuse |
March 19, 1996 |
| The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse. |
| 5484783 |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzaza |
January 16, 1996 |
| The present invention relates to the use of certain mercaptoacetylamide and benzazapine derivatives in treating patients suffering from hypertriglyceridemia, atherosclerosis and hypercholesterolemia. |
| 5478846 |
1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia |
December 26, 1995 |
| The present invention is direct to a new class of 1-piperidinyl alkanoarylsulfonamides of the formula I ##STR1## wherein R, X, m, n, and Alk are defined in the specification, and their use as antiarrhythmic agents. |
| 5428045 |
5-acyl-2-(1H)-pyridinoes |
June 27, 1995 |
| Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 5292752 |
Antithrombotic compounds |
March 8, 1994 |
| The present invention is directed to a new class of piperidinyl medicinal agents which are useful as antithrombotic agents and as serotonin 5HT.sub.2 antagonists. |
| 5286866 |
Piperidinyl compounds |
February 15, 1994 |
| The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists. |
| 5212315 |
Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
May 18, 1993 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 5212314 |
Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
May 18, 1993 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 5166211 |
Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons |
November 24, 1992 |
| The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT.sub.2 antagonists. |
| 5118696 |
5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure |
June 2, 1992 |
| Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 5093341 |
N-aralkyl piperidine derivatives useful as antithrombolytic agents |
March 3, 1992 |
| The present invention is directed to a new class of compounds useful as antiarrhythmics, analgesics and serotonin 5HT.sub.2 antagonists, which compounds have the following formula: ##STR1## wherein; Y is represented by H, CO(CH.sub.2).sub.n CH.sub.3 in which n is an integer from |
| 5043449 |
Certain alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
August 27, 1991 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 5002961 |
Method for reducing injury with imidazol-2-thionecarboxamides |
March 26, 1991 |
| Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart at |
| 4999431 |
Process for preparing quinoline aldehyde and ketone derivatives |
March 12, 1991 |
| This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a brom |
| 4999365 |
Method of reducing reperfusion injury with imidazol-2-thiones |
March 12, 1991 |
| Certain imidazol-2-thiones are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim. |
| 4992452 |
Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure |
February 12, 1991 |
| Novel 5-acyl-2-(1H)-pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 4990519 |
Method of using quinolyloxazole-2-ones as proteinkinase C inhibitors |
February 5, 1991 |
| This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a brom |
| 4927939 |
Cardiotonic aroylthiazolones |
May 22, 1990 |
| Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4920229 |
Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
April 24, 1990 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 4886811 |
Qunolyloxazole-2-ones useful as proteinkinase C inhibitors |
December 12, 1989 |
| This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a brom |
| 4868197 |
Reducing reperfusion injury with 1,3-dihydro-4-methyl-5-(4-methylthio)benzoyl)-2H-imidazol-2-thi |
September 19, 1989 |
| A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage |
| 4868194 |
Imidazole antiarrhythmics |
September 19, 1989 |
| The present invention is directed to a new class of piperidinyl imidazole antiarrhythmic agents and to methods for treating arrhythmias. |
| 4868182 |
Enhancement of prazosin |
September 19, 1989 |
| This invention relates to the synergistic enhancement of certain antihypertensives by the conjunctive use of certain cardiotonic agents. More specifically, this invention relates to the enhancement of the blood pressure lowering effect achieved with alpha.sub.1 -adrenoceptor antagoni |
| 4866182 |
Cardiotonic alkanoyl and aroyl oxazolones |
September 12, 1989 |
| Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4853395 |
Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties |
August 1, 1989 |
| Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 4849522 |
Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
July 18, 1989 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 4803210 |
Cardiotonic tricyclic oxazolones |
February 7, 1989 |
| Tricyclic oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4766212 |
2H-[1]benzoxepino[5,4-b]-1,4-oxazine derivatives |
August 23, 1988 |
| Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-3,4,4a,5,6,11b-hexahydro-10-methoxy-2H-[1]benzoxepino[5,4-b]-1,4-oxa zine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1 |
| 4762849 |
Cardiotonic alkanoylthiazolones |
August 9, 1988 |
| Novel alkanoylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4743607 |
Cardiotonic tricyclic imidazolones |
May 10, 1988 |
| Tricyclic imidazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. The compounds have the formula: ##STR1## |
| 4734422 |
Cardiotonic aroylthiazolones and the use thereof |
March 29, 1988 |
| Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4732982 |
Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones |
March 22, 1988 |
| This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof. |
| 4731371 |
Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents |
March 15, 1988 |
| Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 4623651 |
Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones |
November 18, 1986 |
| Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure. |
| 4568751 |
5-Acyl-2-(1H)-pyridinones |
February 4, 1986 |
| Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic |
| 4560700 |
Pyrrole-3-carboxylate cardiotonic agents |
December 24, 1985 |
| Pyrrole-3-carboxylates of the following general structure ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl group; R.sub.2 is a 1 to 8 carbon atom alkyl group; and R.sub.3 is a hydrogen, lower alkyl, pyridyl, pyridylmethyl, pyrryl, pyrrylmethyl, thienyl, thienylmethyl or phenyl o |
| 4552880 |
Aroylimidazolones |
November 12, 1985 |
| This invention relates to certain substituted aroylimidazolones, their acid and base addition salts thereof, and to their use as cardiotonic agents. |
| 4526981 |
[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
July 2, 1985 |
| 1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-oxymethyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate alcohol or a silver salt with a substituted 4-bromomethyl-1,3-dihydro-2H-im |
| 4447619 |
4-Alkanoylimidazol-2-ones |
May 8, 1984 |
| 4-alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydroge |
| 4418071 |
Cardiotonic imidazolecarboxylic acid derivatives |
November 29, 1983 |
| The use of novel imidazolecarboxylic acid derivatives of the following general structure which are useful as antihypertensives, cardiotonics and antithrombotics ##STR1## wherein Q and T are an oxygen or sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.su |
| 4410540 |
Cardiotonic 4-aroylimidazolidin-2-ones |
October 18, 1983 |
| This invention relates to aroyl-2-imidazolidinones of the following general structure which are useful as cardiotonics and antihypertensive agents ##STR1## wherein Ar is furanyl, thienyl, 1H-pyrrolyl, or phenyl optionally substituted with one or two X groups; X is halogen, hydroxy, l |
| 4405635 |
4-Aroylimidazol-2-ones and their use as pharmaceuticals |
September 20, 1983 |
| Novel 4-aroylimidazol-2-ones of the following general structure which are useful as antihypertensives, cardiotonics, antithrombotics, bronchodilators and uterospasmolytics ##STR1## wherein Ar is 2-furyl, 2-thienyl or phenyl, the latter of which may optionally be substituted with |
| 4405628 |
4-Pyridylimidazolones and method of use |
September 20, 1983 |
| This invention relates to aroylimidazole-2-ones and their acid and base addition salts as well as their use as cardiotonics in the treatment of cardiac failure. |
| 4381393 |
4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
April 26, 1983 |
| 1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-(substituted amino)methyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a substituted 4-bromomethyl-1,3-dihydro-2H-imida |
| 4371737 |
5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
February 1, 1983 |
| 2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a (substituted amino)methyl substituent at the 5-position, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a 5-(bromome |
| 4367236 |
Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
January 4, 1983 |
| 4-Alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydroge |
