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Helmut Blum Patents
Inventor:
Blum; Helmut
Address:
Dusseldorf, DE
No. of patents:
33
Patents:




Patent Number Title Of Patent Date Issued
7078393 Method of producing 1-hydroxy-1,1-diphosphonic acid compounds July 18, 2006
In a method for preparing 1-hydroxy-1,1-diphosphonic acid compounds of the general formula I and/or of their pharmacologically compatible salts ##STR00001## a compound of the formula II ##STR00002## is reacted with a compound P(OSiR.sup.5.sub.3).sub.3-pR.sup.6.sub.p and the reaction
6235695 Cleaning agent with oligoammine activator complexes for peroxide compounds May 22, 2001
Complexes of the transition metals cobalt, iron, copper, and ruthenium having at least one and preferably at least five ammonia ligands are used to activate peroxygen compounds in aqueous cleaning solutions for hard surfaces. Compositions preferably contain 0.0025% to 0.25 by weight of t
6200946 Transition metal ammine complexes as activators for peroxide compounds March 13, 2001
A method of oxidizing, washing, cleaning, or disinfecting a soiled article is provided wherein a peroxygen compound is activated by an effective amount of a complex of the formula (I):wherein M is iron, copper, or ruthenium, x is a number of 0 to 5, L is a ligand, and A is a salt-forming
6153576 Transition-metal complexes used as activators for peroxy compounds November 28, 2000
Described are complexes of the transition metals manganese, iron, cobalt, ruthenium, molybdenum, titanium, vanadium and/or copper containing one or more ligands of general formula (I) ou (II)in which R is a direct bond or an optionally amin-group-substituted alkylene group with 1 to 4 C-
6147043 Machine dishwashing detergents with silver protection November 14, 2000
In machine dishwashing using low-alkaline detergents, the protection of silver was to be guaranteed. This was achieved by using 3-amino-5-alkyl-1,2,4-triazoles and salts thereof as silver protectors in machine dishwashing detergents. In addition, the dishwashing detergents may contai
5898025 Mildly alkaline dishwashing detergents April 27, 1999
A phosphate-free mildly alkaline, dishwashing detergent composition containing:(a) from 20 to 60% by weight of sodium citrate;(b) from 5 to 50% by weight of alkali metal hydrogen carbonate;(c) from 7 to 12% by weight of alkali metal carbonate;(d) from 2 to 20% by weight of a bleaching agent;(e)
5888954 Corrosion inhibitors for silver March 30, 1999
A process for inhibiting the corrosion of silver in a dishwashing detergent solution by adding to the solution an inorganic redox-active substance.
5714318 Simultaneous sequencing of nucleic acids February 3, 1998
The invention concerns a new method for the simultaneous sequencing of nucleic acids using numerous double-stranded DNA adaptors.
5318726 Derivative of aminosuccinic acid as a complexing agent June 7, 1994
3-Hydroxy-2,2'-iminodisuccinic acid, water soluble salts thereof, a process for their preparation, and their use as biodegradable complexing agents in detergents.
5256653 Pharmaceutical preparations containing platinum complexes/phosphonic acid liquid and processes f October 26, 1993
Platinum complexes of the general formula Iin which Y is a phosphonic acid ligand, and the preparation thereof, are described. The platinum complexes are suitable as active substances in pharmaceuticals, in particular for controlling cancers.
4962229 Olefinic diphosphonic acids, a process for their production, their use as thresholders, and comp October 9, 1990
3-R.sup.1 -3-oxoprop-1-ene-1,1-diphosphonic acids corresponding to the following general formula ##STR1## in which R.sup.1 is a tertiary substituted alkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aryl or heteroaryl group, andM is hydrogen or
4939001 Process for sealing anodized aluminum July 3, 1990
In the process of sealing decorative anodized aluminum oxide coatings in hot aqueous solutions, superior results are obtained when the sealing solutions contain 1-phosphonopropane-1,2,3-tricarboxylic acid, 1,1-diphosphonopropane-2,3-dicarboxylic acid, and/or alkali metal and/or alkan
4908138 Hydroxyacetonitrile diphosphonic acid, a process for its production, and its use March 13, 1990
Hydroxyacetonitrile diphosphonic acid corresponding to the following general formula ##STR1## in which M represents H or a cation of a base, and salts thereof; to a process for their preparation comprising reacting 3-R.sup.1 -3-oxo-1-aminopropane-1,1-diphosphonic acids correspond
4892679 Oxa-alkane polyphosphonic acids, their use as thresholders, and complexing compositions containi January 9, 1990
Oxa-alkane polyphosphonic acids corresponding to general formula (I) ##STR1## in which R.sup.1 is a C.sub.1 -C.sub.10 alkyl group, an optionally substituted C.sub.6 -C.sub.10 aryl group, a phenyl- or naphthylalkyl group, a group having the general formula ##STR2## or a group
4880575 Olefinic diphosphonic acids, a process for their production, their use as thresholders and compl November 14, 1989
3-R.sup.1 -3-oxoprop-1-ene-1,1-diphosphonic acids corresponding to the following general formula ##STR1## in which R.sup.1 is a tertiary substituted alkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aryl or heteroaryl group, andM is hydrogen or
4876339 Process for synthesis of azacycloalkane-2,2-diphosponic acids October 24, 1989
A reaction medium of ethanol condensed with 1-20, most preferably 4-6 moles, of ethylene or propylene oxide per mole of ethanol greatly improves the practicality of the preparation of azacycloalkane-2,2-diphosphonic acids of the general formula I: ##STR1## where R means a hydroge
4719050 Diphosponylated oxonitriles, processes and uses therefor, and compositions containing them January 12, 1988
3-Alkyl-3-oxo-1-aminopropane-1,1-diphosphonic acids and water-soluble salts thereof corresponding to the formula ##STR1## in which R.sup.1 represents an unbranched or branched C.sub.1 -C.sub.8 alkyl group, R.sup.2 and R.sup.3 independently of one another represent methyl or ethyl
4702823 Phosphinic acid adducts with maleic acid semiesters, a process for their production and their us October 27, 1987
The invention relates to adducts of phosphinic acid with maleic acid semiesters and salts thereof corresponding to the following general formula ##STR1## in which R.sup.1 is hydrogen or a methyl group,R.sup.2 is a linear or branched, optionally hydroxyl substituted C.sub.8 -C.sub
4624947 4-dimethylamino-1-hydroxybutane-1,1-diphosphonic acid, salts thereof, and processes therefor November 25, 1986
4-Dimethylamino-1-hydroxybutane-1,1-diphosphonic acid and water-soluble salts thereof, methods for their preparation, and uses thereof as complexing agents.
4608368 1-hydroxy-1,1-diphosphonic acids and cytostatic use thereof August 26, 1986
1-hydroxy-1,1-diphosphonic acid compounds corresponding to the following general formula ##STR1## in which R and R.sub.1 represent hydrogen or methyl,X represents hydrogen, halogen, amino, which may be acyl substituted, lower alkyl, which may be substituted by amino or acyl substitut
4536348 Dihydroxyalkane diphosphonic acids August 20, 1985
.alpha.,.omega.-dihydroxyalkane-.alpha.,.alpha.-diphosphonic acids of the formulawherein R represents a phenyl radical, a substituted phenyl radical, or a hydrogen atom, and n is an integer of from 1 to 9,and water-soluble salts thereof, and to compositions containing them. The above dip
4407761 Process for the production of .omega.-amino-1-hydroxyalkylidene-1,1-bisphosphonic acid October 4, 1983
A process for the preparation of a .omega.-amino-1-hydroxyalkylidine-1,1-biphosphonic acid of the formula ##STR1## wherein n is an integer from 3 to 5, consisting essentially of the steps ofreacting an aminocarboxylic acid of the formulawherein m is an integer from 2 to 4, with a pho
4327039 Process for the production of 3-amino-1-hydroxypropane-1,1-diphosphonic acid April 27, 1982
A process for the preparation of 3-amino-1-hydroxypropane-1,1-diphosphonic acid having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and lower alkyl, consisting essentially of the steps of reacting a .beta.-alanine compound s
4267108 Hydroxyalkane diphosphonic acids May 12, 1981
Hydroxyalkane diphosphonic acids having the formula ##STR1## wherein X is a member selected from the group consisting of ##STR2## and their water-soluble salts; as well as the process of preparing the same.The compounds are excellent sequestering agents, especially for alkaline
4141967 Cosmetic deodorant preparations containing alkane diphosphonic acid esters February 27, 1979
Alkane diphosphonic acid esters having the formula ##STR1## wherein R is a straight- or branched-chain alkyl radical having 1 to 6 carbon atoms; and n is an integer of 1 to 6 are deodorants in anhydrous cosmetic preparations for the suppression of body odor.
4125608 Appetite curbing preparation containing an alginate and a diphosphonic acid November 14, 1978
An appetite curbing preparation comprising an alginate and diphosphonic acid or a nontoxic pharmacologically acceptable water-soluble salt thereof as an inhibitor of the precipitation of calcium salts. This preparation is useful for curbing the appetite of a warm-blooded animal.
4120890 Diphosphonoalkane carboxylic acids, process of preparation and methods of use October 17, 1978
Diphosphonoalkane carboxylic acids having the formula ##STR1## wherein R is H or --CH.sub.2 --CH.sub.2 --COOH; as well as their water-soluble salts. The compounds are excellent sequestering agents, especially for alkaline earth and earth metal ions. They are stabilizers for perco
4077997 Diphosphonoalkane carboxylic acids, process of preparation and methods of use March 7, 1978
Diphosphonoalkane carboxylic acids having the formula ##STR1## wherein R is H or --CH.sub.2 --CH.sub.2 --COOH; as well as their water-soluble salts. The compounds are excellent sequestering agents, especially for alkaline earth and earth metal ions. They are stabilizers for perco
4069246 Production of 1-hydroxy-alkane-1,1-diphosphonic acids January 17, 1978
A process for the production of 1-hydroxy-alkane-1,1-diphosphonic acids comprises reacting 1-amino-alkane-1,1-diphosphonic acids with nitrous acid, halides of nitrous acid or a substance forming nitrous acid under the reaction conditions.
4064164 1,3-Di-amino-alkane-1,1-diphosphonic acids and salts December 20, 1977
1,3-Di-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein R.sub.1 and R.sub.2 are members selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms, and R.sub.3 is a member selected from the group consisting of hydrogen and methyl; as we
4054598 1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids and salts October 18, 1977
1-Hydroxy-3-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein X is a member selected from the group consisting of ##STR2## and ##STR3## wherein R.sub.1 is a member selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms an
3965024 Washing agent compositions and washing assistant composition containing phosphonopolycarboxylate June 22, 1976
Washing agent compositions and washing assistant compositions containing from 0.5% to 70% by weight of a phosphonopolycarboxylate having the formula ##EQU1## WHEREIN Me is H, alkali metal, or H.NR.sub.3, R.sub.1 is H or CH.sub.3, R.sub.2 is H, alkyl having 1 to 4 carbon atoms or
3962433 Method of treatment of calcium disorders using phosphonoalkane-polycarboxylic acids June 8, 1976
A method for the treatment of diseases relating to the abnormal deposition or dissolution of difficutly soluble calcium salts in the body of warm-blooded animals which consists of administering orally, parenterally or topically to said warm-blooded animals, a safe but effective amount of


 
 
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