| Patent Number |
Title Of Patent |
Date Issued |
| 7378511 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
May 27, 2008 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 7368536 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
May 6, 2008 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 7041473 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
May 9, 2006 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protein and associat |
| 6913918 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
July 5, 2005 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6867018 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
March 15, 2005 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6828117 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
December 7, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6825023 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
November 30, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6797487 |
Polynucleotides encoding alzheimer's disease secretase |
September 28, 2004 |
| The present invention provides methods of reducing cellular production of amyloid beta (A.beta.) from amyloid precursor protein (APP) by reducing Asp2 transcription or translation in cells. |
| 6790610 |
Alzheimer's disease, secretase, APP substrates therefor, and uses therefor |
September 14, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6753163 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
June 22, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6737510 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
May 18, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6727074 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
April 27, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6706485 |
Method of identifying agents that inhibit APP processing activity |
March 16, 2004 |
| The present invention provides methods of identifying agents that inhibit the amyloid precursor protein (APP) processing activity of Asp2 polypeptide. |
| 6699671 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
March 2, 2004 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6500667 |
Aspartyl protease 2 (Asp2) antisense oligonucleotides |
December 31, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6440698 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
August 27, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6440694 |
TNF-related death ligand |
August 27, 2002 |
| The invention relates to a novel tumor necrosis factor (TNF) homolog designated herein as TNF-related death ligand (TRDL). Isolated nucleic acid molecules are provided which encode TRDL. TRDL polypeptides are also provided, as are methods for identifying agonists and antagonists of TRDL |
| 6420534 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
July 16, 2002 |
| The present invention provides the enzyme and enzymatic procedures for cleaving the .beta. secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associa |
| 6031089 |
Sequences of p56, proteins which affect K-ATP channels |
February 29, 2000 |
| This invention describes the full length sequence of human p56 protein (p56-1), a related homolog (p56-2) and the nucleic acids that code for these proteins. The sequences are provided in Charts 1, 2, 3, and 4 and the sequence listings of the application. |
| 5831055 |
DNA encoding a novel kidney ATP-dependent potassium channels |
November 3, 1998 |
| The present invention comprises human DNA compositions, including cDNA clones, with full sequences, called, KIRK-2 and KIRK-3, encoding proteins that confer potassium channel activity to membranes or recipient cell lines. The DNA compositions include structural genes coding for the p |
