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Karnail S. Atwal Patents |
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Inventor: Atwal; Karnail S.
Address: Newtown, PA
No. of patents: 31
Patents:
| Patent Number |
Title Of Patent |
Date Issued |
| 7326705 |
Heterocyclic sodium/proton exchange inhibitors and method |
February 5, 2008 |
| Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR00001## wherein n is 1 to 5; X is N or C--R.sup.5 wherein R.sup.5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl group, R.sup.1, R.sup.2, R.s |
| 7157451 |
Heterocyclic dihydropyrimidine compounds |
January 2, 2007 |
| Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K.sub.v1 subfamily of voltage gated K.sup.+ channels, especially inhibitors K.sub.v1.5 which has been linked to the ultra-rapidly activating delayed rectifi |
| 6916813 |
(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolas |
July 12, 2005 |
| Compounds having the formula (I), and pharmaceutically acceptable salts thereof, ##STR1##are useful for modulating mitochondrial F.sub.1 F.sub.0 ATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias. |
| 6887870 |
Heterocyclic sodium/proton exchange inhibitors and method |
May 3, 2005 |
| Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1##wherein n is 1 to 5; X is N or C--R.sup.5 wherein R.sup.5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R.sup.1, R.sup.2, R.sup.3 a |
| 6881753 |
Potassium channel inhibitors and method |
April 19, 2005 |
| Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: ##STR1##where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a metho |
| 6784189 |
Potassium channel inhibitors and method |
August 31, 2004 |
| Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1##where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method |
| 6706720 |
Heterocyclic dihydropyrimidine compounds |
March 16, 2004 |
| Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K.sub.v 1 subfamily of voltage gated K.sup.+ channels, especially inhibitors K.sub.v 1.5 which has been linked to the ultra-rapidly activating delayed recti |
| 6664250 |
Lactam derivatives as antiarrhythmic agents |
December 16, 2003 |
| Lactam derivatives of the formula ##STR1##where X is --C(.dbd.O)NR.sup.3' --, --NR.sup.3' C(.dbd.O)--, --C(.dbd.NCN)NR.sup.3' --, --NR.sup.3' C(.dbd.NCN)--, --CH.sub.2 NR.sup.3' --, --CH(alkyl)NR.sup.3' --, --CH(COOalkyl)NR.sup.3' --, --CH(CH.sub.2 OH)NR.sup.3' --, --C(CH.sub.2 Oa |
| 6624309 |
Benzoic acid derivatives and related compounds as antiarrhythmic agents |
September 23, 2003 |
| Benzoic acid derivatives of the formula ##STR1##where X is oxygen, sulfur, --NH, --NR.sup.1, --N--CN, --N--OR.sup.1 or --N--NO.sub.2 ; Y is a single bond, --C.dbd.C--, or --NH; R.sup.1 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocyclo, or (heterocyclo)alkyl; and R.sup |
| 6511977 |
Potassium channel inhibitors and method |
January 28, 2003 |
| Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1##where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a method |
| 6472427 |
Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile |
October 29, 2002 |
| The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness. |
| 6458835 |
Method of inhibiting or treating chemotherapy-induced hair loss |
October 1, 2002 |
| A method for inhibiting hair loss and/or promoting hair growth in chemotherapy and/or radiation therapy patients wherein the (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile is administered prior to, simultaneous with and/or after chemotherap |
| 6262122 |
Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile |
July 17, 2001 |
| The (R)-enantiomer of 4-[[(cyanoimino)-[(1,2,2-trimethylpropyl)amino]methyl]amino]-benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness. |
| 6262068 |
Lactam derivatives as antiarrhythmic agents |
July 17, 2001 |
| Lactam derivatives of the formula ##STR1##whereX is --C(.dbd.O)NR.sup.3' --, --NR.sup.3' C(.dbd.O)--, --C(.dbd.NCN)NR.sup.3' --, --NR.sup.3' C(.dbd.NCN)--, --CH.sub.2 NR.sup.3' --, --CH(alkyl)NR.sup.3' --, --CH(COOalkyl)NR.sup.3' --, --CH(CH.sub.2 OH)NR.sup.3' --, --C(CH.sub.2 Oalkyl |
| 6160134 |
Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines |
December 12, 2000 |
| A process is provided for preparing chiral cyclopropane carboxylic acids, preferably of the structure ##STR1## which are intermediates used in preparing acyl guanidine sodium/proton exchange (NHE) inhibitors. |
| 6150356 |
Potassium channel inhibitors and method |
November 21, 2000 |
| Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X.sup.1, R, R.sup.1, X.sup.2 and R.sup.2 are as defined herein. These compounds are useful as antiarrhythmic agents. In addition, a m |
| 6048877 |
Tetralone derivatives as antiarrhythmic agents |
April 11, 2000 |
| Tetralone derivatives of the formula ##STR1## where R.sup.1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted |
| 6013668 |
Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile |
January 11, 2000 |
| The (R)-enantiomer of 4-[[(cyanoimino)[(1,2,2-trimethylpropyl)amino]methyl]amino]benzonitrile as well as the corresponding (S)-enantiomer are useful for promoting hair growth such as in male pattern baldness. |
| 6011059 |
Acyl guanidine sodium/proton exchange inhibitors and method |
January 4, 2000 |
| Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 1 to 5; X is N or C--R.sup.5 wherein R.sup.5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 ar |
| 5869478 |
Sulfonamido substituted benzopyran derivatives |
February 9, 1999 |
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| 5837702 |
4-arylamino-benzopyran and related compounds |
November 17, 1998 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup.8)-- where R.sup.8 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl, and R |
| 5612370 |
Phenylglycine and phenylalaninen amido benzopyran derivatives |
March 18, 1997 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein a, b and d are all carbon atoms or one of a, b and d is a nitrogen atom or --N(O)-- and the others are carbon atoms; Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup. |
| 5547966 |
Aryl urea and related compounds |
August 20, 1996 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is a single bond, O, CO, S, NH or N(lower alkyl); Y is O, S or NCN; and R.sup.1 to R.sup.5' are as defined herein. These compounds have potassium channel activating activity and are usef |
| 5514690 |
Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline and indoline |
May 7, 1996 |
| Novel compounds having potassium channel activating activity and useful, for example, as antiischemic agents are disclosed. These compounds have the general formula ##STR1## wherein A is ##STR2## or a single bond to complete an indoline nucleus; X is --O--, --S-- or --NCN |
| 5453421 |
Aryl and heterocyclic substituted propenamide derivatives |
September 26, 1995 |
| Novel compounds useful, for example, for the treatment of ischemic conditions and arrhythmia are disclosed. The compounds have the formula ##STR1## wherein X is oxygen or sulfur and the R groups are as defined herein. |
| 5401758 |
Pyridinyl cyanoguanidine compounds |
March 28, 1995 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 to R.sup.4 and n are as defined herein and X is O, S or NCN. These compounds have potassium channel opening activity and are useful, therefore for example, as cardiovascular agents |
| 5393771 |
4-substituted benzopyran and related compounds |
February 28, 1995 |
| Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents. |
| 5374643 |
Aryl urea (thiourea) and cyanoguanidine derivatives |
December 20, 1994 |
| Novel compounds useful, for example, in the treatment of ischemic conditions and arrhythmia having the formula I ##STR1## wherein X is oxygen, sulfur or --NCN and the R groups are as defined herein. |
| 5350752 |
Dihydropyrimidine derivatives |
September 27, 1994 |
| Novel A-II receptor antagonists have the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6, are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypert |
| 5234923 |
Substitute indole and benzimidazole derivatives |
August 10, 1993 |
| Novel compounds are disclosed having the formula ##STR1## or its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as |
| 5212177 |
Indole and benzimidazole-substituted dihydropyrimidine derivatives |
May 18, 1993 |
| Novel compounds having the formula ##STR1## and its isomer ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and X are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, an antihypertens |
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